| Literature DB >> 29799737 |
Daiqin Chen1,2,3, Guoqiang Zhang1,2, Ruimin Li1,2, Mirong Guan1,2, Xueyun Wang1,2, Toujun Zou1,2, Ying Zhang1,2, Chunru Wang1, Chunying Shu1, Hao Hong3, Li-Jun Wan1,2.
Abstract
Reactive oxygen species (ROS) and glutathione (GSH) dual responsive nanoparticulate drug delivery systems (nano-DDSs) hold great promise to improve the therapeutic efficacy and alleviate the side effects of chemo drugs in cancer theranosis. Herein, hydrogen peroxide (H2O2) and GSH dual responsive thioketal nanoparticle (TKN) was rationally designed for paclitaxel (PTX) delivery. Compared to other stimuli-sensitive nano-DDSs, this dual responsive DDS is not only sensitive to biologically relevant H2O2 and GSH for on-demand drug release but also biodegradable into biocompatible byproducts after fulfilling its delivering task. Considering the heterogeneous redox potential gradient, the PTX loaded TKNs (PTX-TKNs) might first respond to the extracellular ROS and then to the intracellular GSH, achieving a programmable release of PTX at the tumor site. The selective toxicity of PTX-TKNs to tumor cells with high levels of ROS and GSH was verified both in vitro and in vivo.Entities:
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Year: 2018 PMID： 29799737 DOI： 10.1021/jacs.7b12025
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419