| Literature DB >> 31279098 |
William C Ballance1, Ellen C Qin2, Hee Jung Chung3, Martha U Gillette4, Hyunjoon Kong5.
Abstract
Neurodegenerative diseases and disorders seriously impact memory and cognition and can become life-threatening. Current medical techniques attempt to combat these detrimental effects mainly through the administration of neuromedicine. However, drug efficacy is limited by rapid dispersal of the drugs to off-target sites while the site of administration is prone to overdose. Many neuropathological conditions are accompanied by excessive reactive oxygen species (ROS) due to the inflammatory response. Accordingly, ROS-responsive drug delivery systems have emerged as a promising solution. To guide intelligent and comprehensive design of ROS-responsive drug delivery systems, this review article discusses the two following topics: (1) the biology of ROS in both healthy and diseased nervous systems and (2) recent developments in ROS-responsive, drug delivery system design. Overall, this review article would assist efforts to make better decisions about designing ROS-responsive, neural drug delivery systems, including the selection of ROS-responsive functional groups.Entities:
Keywords: Drug delivery; Neuroinflammation; Neurological disorders; Reactive oxygen species
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Year: 2019 PMID： 31279098 PMCID： PMC7081518 DOI： 10.1016/j.biomaterials.2019.119292
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479