| Literature DB >> 29796816 |
K N Bardakova1,2, E A Grebenik2, E V Istranova2, L P Istranov2, Yu V Gerasimov3, A G Grosheva3, T M Zharikova2, N V Minaev1, B S Shavkuta1,2, D S Dudova1, S V Kostyuk4, N N Vorob'eva1, V N Bagratashvili1, P S Timashev1,2, R K Chailakhyan5,6.
Abstract
We created an anisotropic material based on collagen sponge and reactive polylactide structured by laser photopolymerization. The combination of collagen with reactive polylactide improves the resistance of the formed matrices to biodegradation in comparison with collagen sponge, while the existence of sites with different mechanical characteristics and cell affinity on the matrix provides directed cell growth during their culturing. It was shown that reinforcement of the collagen sponges 7-fold increased the mean Young's modulus for the hybrid matrix without affecting its cytotoxicity. The developed matrix provides cell adhesion and proliferation along reinforcement lines and can be used for fabrication of tissue engineering constructs.Entities:
Keywords: branched polylactide; collagen matrix; directed cell growth; laser photopolymerization; multipotent stromal cells
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Year: 2018 PMID： 29796816 DOI： 10.1007/s10517-018-4116-8
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804