Literature DB >> 29792915

The CD44-HA axis and inflammation in atherosclerosis: A temporal perspective.

Mia Krolikoski1, James Monslow1, Ellen Puré2.   

Abstract

Cardiovascular disease (CVD) due to atherosclerosis is a disease of chronic inflammation at both the systemic and the tissue level. CD44 has previously been implicated in atherosclerosis in both humans and mice. This multi-faceted receptor plays a critical part in the inflammatory response during the onset of CVD, though little is known of CD44's role during the latter stages of the disease. This review focuses on the role of CD44-dependent HA-dependent effects on inflammatory cells in several key processes, from disease initiation throughout the progression of atherosclerosis. Understanding how CD44 and HA regulate inflammation in atherogenesis is key in determining the utility of the CD44-HA axis as a therapeutic target to halt disease and potentially promote disease regression.
Copyright © 2018 International Society of Matrix Biology. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Atherosclerosis; CD44; Hyaluronan; Inflammation

Mesh:

Substances:

Year:  2018        PMID: 29792915      PMCID: PMC6249119          DOI: 10.1016/j.matbio.2018.05.007

Source DB:  PubMed          Journal:  Matrix Biol        ISSN: 0945-053X            Impact factor:   11.583


  175 in total

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