Lotte H J M Lemmens1, Suzanne C van Bronswijk2, Frenk Peeters2, Arnoud Arntz3, Steven D Hollon4, Marcus J H Huibers5. 1. Department of Clinical Psychological Science,Faculty of Psychology and Neuroscience,Maastricht University,P.O. Box 616, 6200 MD Maastricht,The Netherlands. 2. Department of Psychiatry and Psychology, Faculty of Health, Medicine and Life Sciences,Maastricht University,P.O. Box 616, 6200 MD, Maastricht,The Netherlands. 3. Department of Clinical Psychology,University of Amsterdam,PO Box 19268, 1000 GG Amsterdam,The Netherlands. 4. Department of Psychology,Vanderbilt University,306 Wilson Hall, Nashville, Tennessee,USA. 5. Department of Clinical Psychology,VU University Amsterdam,Van der Boechorststraat 1, 1081 BT Amsterdam,The Netherlands.
Abstract
BACKGROUND: Although equally efficacious in the acute phase, it is not known how cognitive therapy (CT) and interpersonal psychotherapy (IPT) for major depressive disorder (MDD) compare in the long run. This study examined the long-term outcomes of CT v. IPT for MDD. METHODS:One hundred thirty-four adult (18-65) depressed outpatients who were treated with CT (n = 69) orIPT (n = 65) in a large open-label randomized controlled trial (parallel group design; computer-generated block randomization) were monitored across a 17-month follow-up phase. Mixed regression was used to determine the course of self-reported depressive symptom severity (Beck Depression Inventory II; BDI-II) after treatment termination, and to test whether CT and IPT differed throughout the follow-up phase. Analyses were conducted for the total sample (n = 134) and for the subsample of treatment responders (n = 85). Furthermore, for treatment responders, rates of relapse and sustained response were examined for self-reported (BDI-II) and clinician-rated (Longitudinal Interval Follow-up Evaluation; LIFE) depression using Cox regression. RESULTS: On average, the symptom reduction achieved during the 7-month treatment phase was maintained across follow-up (7-24 months) for CT and IPT, both in the total sample and in the responder sample. Two-thirds (67%) of the treatment responders did not relapse across the follow-up period on the BDI-II. Relapse rates assessed with the LIFE were somewhat lower. No differential effects between conditions were found. CONCLUSIONS: Patients who responded to IPT were no more likely to relapse following treatment termination than patients who responded to CT. Given that CT appears to have a prophylactic effect following successful treatment, our findings suggest that IPT might have a prophylactic effect as well.
RCT Entities:
BACKGROUND: Although equally efficacious in the acute phase, it is not known how cognitive therapy (CT) and interpersonal psychotherapy (IPT) for major depressive disorder (MDD) compare in the long run. This study examined the long-term outcomes of CT v. IPT for MDD. METHODS: One hundred thirty-four adult (18-65) depressed outpatients who were treated with CT (n = 69) or IPT (n = 65) in a large open-label randomized controlled trial (parallel group design; computer-generated block randomization) were monitored across a 17-month follow-up phase. Mixed regression was used to determine the course of self-reported depressive symptom severity (Beck Depression Inventory II; BDI-II) after treatment termination, and to test whether CT and IPT differed throughout the follow-up phase. Analyses were conducted for the total sample (n = 134) and for the subsample of treatment responders (n = 85). Furthermore, for treatment responders, rates of relapse and sustained response were examined for self-reported (BDI-II) and clinician-rated (Longitudinal Interval Follow-up Evaluation; LIFE) depression using Cox regression. RESULTS: On average, the symptom reduction achieved during the 7-month treatment phase was maintained across follow-up (7-24 months) for CT and IPT, both in the total sample and in the responder sample. Two-thirds (67%) of the treatment responders did not relapse across the follow-up period on the BDI-II. Relapse rates assessed with the LIFE were somewhat lower. No differential effects between conditions were found. CONCLUSIONS:Patients who responded to IPT were no more likely to relapse following treatment termination than patients who responded to CT. Given that CT appears to have a prophylactic effect following successful treatment, our findings suggest that IPT might have a prophylactic effect as well.
Authors: Suzanne C van Bronswijk; Lotte H J M Lemmens; John R Keefe; Marcus J H Huibers; Robert J DeRubeis; Frenk P M L Peeters Journal: Depress Anxiety Date: 2018-12-05 Impact factor: 6.505
Authors: Katherine S Bright; Elyse M Charrois; Muhammad Kashif Mughal; Abdul Wajid; Deborah McNeil; Scott Stuart; K Alix Hayden; Dawn Kingston Journal: Syst Rev Date: 2019-10-29
Authors: Katherine S Bright; Muhammad Kashif Mughal; Abdul Wajid; Marie Lane-Smith; Lindsay Murray; Nicola Roy; Sander Veldhuyzen Van Zanten; Deborah A Mcneil; Scott Stuart; Dawn Kingston Journal: Trials Date: 2019-12-30 Impact factor: 2.279
Authors: Suzanne C van Bronswijk; Robert J DeRubeis; Lotte H J M Lemmens; Frenk P M L Peeters; John R Keefe; Zachary D Cohen; Marcus J H Huibers Journal: Psychol Med Date: 2019-11-22 Impact factor: 7.723
Authors: Jaël S van Bentum; Suzanne C van Bronswijk; Marit Sijbrandij; Lotte H J M Lemmens; Frenk F P M L Peeters; Marjan Drukker; Marcus J H Huibers Journal: Depress Anxiety Date: 2021-03-23 Impact factor: 6.505