| Literature DB >> 29785881 |
Steve Turner1, Ben Francis2, Nuha Wani1, Susanne Vijverberg3,4, Maria Pino-Yanes5, Somnath Mukhopadhyay6,7, Roger Tavendale7, Colin Palmer7, Esteban G Burchard8,9, Simon Kebede Merid10, Erik Melén10,11, Anke H Maitland-van der Zee3,4, On Behalf Of The Pharmacogenomics In Childhood Asthma Consortium.
Abstract
Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.Entities:
Keywords: asthma; child; exacerbation; glutathione S-transferase; severity; tobacco smoke
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Year: 2018 PMID： 29785881 PMCID： PMC6021964 DOI： 10.2217/pgs-2018-0027
Source DB: PubMed Journal: Pharmacogenomics ISSN： 1462-2416 Impact factor: 2.533