Literature DB >> 29785480

Potential Treatment Options in a Post-antibiotic Era.

R R Bragg1, C M Meyburgh2, J-Y Lee2, M Coetzee2.   

Abstract

Following the Golden Age of antibiotic discovery in the previous century, the rate of antibiotic discovery has plummeted during the past 50 years while the incidence of antimicrobial resistance is ever-increasing. Presently, humankind is forced to address a major public health threat in the form of multiple drug resistance and urgent action is required to halt the advent of a post-antibiotic era. This chapter aims to draw the attention to the escalating global crisis of antimicrobial resistance fueled by the irresponsible use of antibiotics in healthcare and animal production sectors. The merits of alternative prevention and treatment options, including vaccines, herbal products, bacteriophages, and improved biosecurity measures are also discussed.

Keywords:  Antibiotics; Antimicrobial resistance; Bacteriophages; Essential oils; Vaccines

Mesh:

Substances:

Year:  2018        PMID: 29785480     DOI: 10.1007/978-981-10-7572-8_5

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN: 0065-2598            Impact factor:   2.622


  14 in total

Review 1.  Connecting iron acquisition and biofilm formation in the ESKAPE pathogens as a strategy for combatting antibiotic resistance.

Authors:  Savannah J Post; Justin A Shapiro; William M Wuest
Journal:  Medchemcomm       Date:  2019-03-21       Impact factor: 3.597

Review 2.  Novel Treatment Strategies for Biofilm-Based Infections.

Authors:  Claudia Vuotto; Gianfranco Donelli
Journal:  Drugs       Date:  2019-10       Impact factor: 9.546

3.  Calcium sulfate beads made with antibacterial essential oil-water emulsions exhibit growth inhibition against Staphylococcus aureus in agar pour plates.

Authors:  Allison N Hawkins; Sara J Licea; Sierra A Sleeper; Matthew C Swearingen
Journal:  PLoS One       Date:  2022-07-08       Impact factor: 3.752

4.  BD-2 and BD-3 increase skin flap survival in a model of ischemia and Pseudomonas aeruginosa infection.

Authors:  Diogo Casal; Inês Iria; José S Ramalho; Sara Alves; Eduarda Mota-Silva; Luís Mascarenhas-Lemos; Carlos Pontinha; Maria Guadalupe-Cabral; José Ferreira-Silva; Mário Ferraz-Oliveira; Valentina Vassilenko; João Goyri-O'Neill; Diogo Pais; Paula A Videira
Journal:  Sci Rep       Date:  2019-05-27       Impact factor: 4.379

5.  In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens.

Authors:  Lucia Blasco; Anton Ambroa; Luis Martínez-Martínez; Maria Tomas; Rocio Trastoy; Ines Bleriot; Miriam Moscoso; Laura Fernández-Garcia; Elena Perez-Nadales; Felipe Fernández-Cuenca; Julian Torre-Cisneros; Jesus Oteo-Iglesias; Antonio Oliver; Rafael Canton; Tim Kidd; Ferran Navarro; Elisenda Miró; Alvaro Pascual; German Bou
Journal:  Sci Rep       Date:  2020-04-28       Impact factor: 4.379

6.  Ketone- and Cyano-Selenoesters to Overcome Efflux Pump, Quorum-Sensing, and Biofilm-Mediated Resistance.

Authors:  Nikoletta Szemerédi; Annamária Kincses; Katerina Rehorova; Lan Hoang; Noemi Salardón-Jiménez; Clotilde Sevilla-Hernández; Jitka Viktorová; Enrique Domínguez-Álvarez; Gabriella Spengler
Journal:  Antibiotics (Basel)       Date:  2020-12-11

7.  Combined in-vitro and on-farm evaluation of commercial disinfectants used against Brachyspira hyodysenteriae.

Authors:  Manuel Gómez-García; Héctor Argüello; Lucía Pérez-Pérez; Clara Vega; Héctor Puente; Óscar Mencía-Ares; Pedro Rubio; Ana Carvajal
Journal:  Porcine Health Manag       Date:  2022-01-08

8.  Investigating Bacteriophages Targeting the Opportunistic Pathogen Acinetobacter baumannii.

Authors:  Kathryn M Styles; Rapee Thummeepak; Udomluk Leungtongkam; Sophie E Smith; Gabrielle S Christie; Andrew Millard; John Moat; Christopher G Dowson; Elizabeth M H Wellington; Sutthirat Sitthisak; Antonia P Sagona
Journal:  Antibiotics (Basel)       Date:  2020-04-22

9.  ISG15 Acts as a Mediator of Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6J Mouse Corneas.

Authors:  Nan Gao; Rao Me; Chenyang Dai; Fu-Shin X Yu
Journal:  Invest Ophthalmol Vis Sci       Date:  2020-05-11       Impact factor: 4.799

10.  There is no market for new antibiotics: this allows an open approach to research and development.

Authors:  Dana M Klug; Fahima I M Idiris; Mark A T Blaskovich; Frank von Delft; Christopher G Dowson; Claas Kirchhelle; Adam P Roberts; Andrew C Singer; Matthew H Todd
Journal:  Wellcome Open Res       Date:  2021-06-11
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