Literature DB >> 29779866

Nucleolar Function in Lifespan Regulation.

Varnesh Tiku1, Adam Antebi2.   

Abstract

The nucleolus is a prominent membraneless organelle residing within the nucleus. The nucleolus has been regarded as a housekeeping structure mainly known for its role in ribosomal RNA (rRNA) production and ribosome assembly. However, accumulating evidence has revealed its functions in numerous cellular processes that control organismal physiology, thereby taking the nucleolus much beyond its conventional role in ribosome biogenesis. Perturbations in nucleolar functions have been associated with severe diseases such as cancer and progeria. Recent studies have also uncovered the role of the nucleolus in development and aging. In this review we discuss major nucleolar functions that impact organismal aging.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  aging; lifespan; nucleolus; nutrient sensing pathways; ribosome biogenesis

Mesh：

Substances：

Year:  2018        PMID： 29779866     DOI： 10.1016/j.tcb.2018.03.007

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  44 in total

Review 1.  The peculiar genetics of the ribosomal DNA blurs the boundaries of transgenerational epigenetic inheritance.

Authors:  Farah Bughio; Keith A Maggert
Journal:  Chromosome Res       Date:  2018-12-04       Impact factor: 5.239

Review 2.  Nucleolus and rRNA Gene Chromatin in Early Embryo Development.

Authors:  Jelena Kresoja-Rakic; Raffaella Santoro
Journal:  Trends Genet       Date:  2019-07-18       Impact factor: 11.639

Review 3.  Lipodystrophy-associated progeroid syndromes.

Authors:  David Araújo-Vilar; Antía Fernández-Pombo; Silvia Cobelo-Gómez; Ana I Castro; Sofía Sánchez-Iglesias
Journal:  Hormones (Athens)       Date:  2022-07-15       Impact factor: 3.419

Review 4.  The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging.

Authors:  Stephanie A Fernandes; Constantinos Demetriades
Journal:  Front Aging       Date:  2021-08-27

Review 5.  Ribosomopathies: Old Concepts, New Controversies.

Authors:  Katherine I Farley-Barnes; Lisa M Ogawa; Susan J Baserga
Journal:  Trends Genet       Date:  2019-07-31       Impact factor: 11.639

6.  Surface Fluctuations and Coalescence of Nucleolar Droplets in the Human Cell Nucleus.

Authors:  Christina M Caragine; Shannon C Haley; Alexandra Zidovska
Journal:  Phys Rev Lett       Date:  2018-10-05       Impact factor: 9.161

Review 7.  Nuclear architecture as an intrinsic regulator of Drosophila female germline stem cell maintenance.

Authors:  Tingting Duan; Nicole Green; Tina L Tootle; Pamela K Geyer
Journal:  Curr Opin Insect Sci       Date:  2020-01-30       Impact factor: 5.186

Review 8.  The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation.

Authors:  Ivana Bjedov; Charalampos Rallis
Journal:  Genes (Basel)       Date:  2020-09-03       Impact factor: 4.096

Review 9.  Close to the edge: Heterochromatin at the nucleolar and nuclear peripheries.

Authors:  Aizhan Bizhanova; Paul D Kaufman
Journal:  Biochim Biophys Acta Gene Regul Mech       Date:  2020-12-08       Impact factor: 4.490

10.  MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells.

Authors:  Bieke Decaesteker; Winnok H De Vos; Sofia Zanotti; Suzanne Vanhauwaert; Christophe Van Neste; Volodimir Olexiouk; Jolien Van Laere; Marlies Verschuuren; Joni Van der Meulen; Liselot M Mus; Kaat Durinck; Laurentijn Tilleman; Dieter Deforce; Filip Van Nieuwerburgh; Michael D Hogarty; Frank Speleman
Journal:  Sci Rep       Date:  2021-07-14       Impact factor: 4.379
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