Yang-Yang Qian1, Shu-Guang Zhu2, Xi Hou1, Wei Zhou1, Wei An1, Xiao-Ju Su1, Mark Edward McAlindon3, Zhao-Shen Li4, Zhuan Liao5. 1. Department of Gastroenterology, Changhai Hospital, Second Military Medical Universtiy, National Clinical Research Center for Digestive Diseases, Shanghai, China. 2. Department of Gastroenterology, Changhai Hospital, Second Military Medical Universtiy, National Clinical Research Center for Digestive Diseases, Shanghai, China; Department of Gastroenterology, Anqing Municipal Hospital of Anhui Medical University, Anqing, China. 3. Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, UK. 4. Department of Gastroenterology, Changhai Hospital, Second Military Medical Universtiy, National Clinical Research Center for Digestive Diseases, Shanghai, China. Electronic address: zhaoshenli@hotmail.com. 5. Department of Gastroenterology, Changhai Hospital, Second Military Medical Universtiy, National Clinical Research Center for Digestive Diseases, Shanghai, China. Electronic address: liaozhuan@smmu.edu.cn.
Abstract
BACKGROUND: Magnetically controlled capsule gastroscopy (MCCG) is a newly developed non-invasive method designed for gastric examination. Although favorable diagnostic accuracy has been reported, there is little if any data about its ability to diagnose gastric cancer. AIMS: To compare the detectability of superficial gastric neoplasia by MCCG and gastroscopy. METHODS: This study was a self-controlled comparison study. Ten subjects diagnosed with superficial gastric neoplasia and scheduled to undergo endoscopic submucosal dissection (ESD) at a tertiary hospital were prospectively invited for an MCCG examination. The diagnostic agreement of MCCG, ESD and pathology were compared, including location, size and endoscopic appearance of the lesions. RESULTS: Of the 10 enrolled patients, 6 were confirmed as having early gastric cancer/high-grade intraepithelial neoplasia, 2 gastric low-grade intraepithelial neoplasia (LGIN), 1 tubular adenoma with LGIN and 1 neuroendocrine tumor. The per-patient and per-lesion sensitivities of MCCG for superficial gastric neoplasia detection were 100% and 91.7%. Location and size of the lesions were compared favorably to gastroscopy whilst one cardiac lesion was missed. Endoscopic appearances of these lesions observed on MCCG and EGD demonstrated good consistency. No adverse events were observed. CONCLUSION: With good gastric preparation and careful examination of stomach, MCCG is able to detect superficial gastric neoplasms.
BACKGROUND: Magnetically controlled capsule gastroscopy (MCCG) is a newly developed non-invasive method designed for gastric examination. Although favorable diagnostic accuracy has been reported, there is little if any data about its ability to diagnose gastric cancer. AIMS: To compare the detectability of superficial gastric neoplasia by MCCG and gastroscopy. METHODS: This study was a self-controlled comparison study. Ten subjects diagnosed with superficial gastric neoplasia and scheduled to undergo endoscopic submucosal dissection (ESD) at a tertiary hospital were prospectively invited for an MCCG examination. The diagnostic agreement of MCCG, ESD and pathology were compared, including location, size and endoscopic appearance of the lesions. RESULTS: Of the 10 enrolled patients, 6 were confirmed as having early gastric cancer/high-grade intraepithelial neoplasia, 2 gastric low-grade intraepithelial neoplasia (LGIN), 1 tubular adenoma with LGIN and 1 neuroendocrine tumor. The per-patient and per-lesion sensitivities of MCCG for superficial gastric neoplasia detection were 100% and 91.7%. Location and size of the lesions were compared favorably to gastroscopy whilst one cardiac lesion was missed. Endoscopic appearances of these lesions observed on MCCG and EGD demonstrated good consistency. No adverse events were observed. CONCLUSION: With good gastric preparation and careful examination of stomach, MCCG is able to detect superficial gastric neoplasms.
Authors: Milán Szalai; Krisztina Helle; Barbara Dorottya Lovász; Ádám Finta; András Rosztóczy; László Oczella; László Madácsy Journal: World J Gastroenterol Date: 2022-05-28 Impact factor: 5.374