Xinxin Huang1, Samuel Yong-Ern Ng2, Nicole Shuang-Yu Chia2, Sanchalika Acharyya1, Fiona Setiawan2, Z-H Lu2, Ebonne Ng2, Kay-Yaw Tay3, Wing-Lok Au3, Eng-King Tan3, Louis Chew-Seng Tan4. 1. Duke-NUS Graduate Medical School, Singapore. 2. Department of Neurology, National Neuroscience Institute, Singapore; Parkinson's Disease and Movement Disorders Centre (NPF International Center of Excellence), National Neuroscience Institute, Singapore. 3. Department of Neurology, National Neuroscience Institute, Singapore; Parkinson's Disease and Movement Disorders Centre (NPF International Center of Excellence), National Neuroscience Institute, Singapore; Duke-NUS Graduate Medical School, Singapore. 4. Department of Neurology, National Neuroscience Institute, Singapore; Parkinson's Disease and Movement Disorders Centre (NPF International Center of Excellence), National Neuroscience Institute, Singapore; Duke-NUS Graduate Medical School, Singapore. Electronic address: louis_tan@nni.com.sg.
Abstract
OBJECTIVE: Uric acid has been found to be potentially neuroprotective in Parkinson's disease (PD). We investigated the relationship between serum uric acid levels and both motor and non-motor features in a prospective early PD cohort study. METHODS: Fasting serum uric acid levels were measured from 125 early PD patients. Demographic, clinical characteristics, motor and non-motor assessments were performed. Patients were categorized into three motor subtypes: tremor-dominant (TD), postural instability/gait difficulty (PIGD), and mixed. Non-motor symptoms were classified as present or absent based on the appropriate cut-offs for each non-motor instrument. RESULTS: Most patients had TD (n = 51, 40.8%) and mixed (n = 63, 50.4%) motor subtypes, while a minority had PIGD (n = 11, 8.8%) motor subtype. The mean serum uric acid levels were significantly different between the three motor subtypes (p = 0.0106), with the mixed subtype having the lowest serum uric acid levels. Using the TD subtype as reference, patients with higher serum uric acid levels were less likely to have the mixed (OR = 0.684; p = 0.0312) subtype as opposed to the TD subtype. Uric acid levels were not significantly different between the TD and PIGD subtypes. For non-motor symptoms, higher serum uric acid levels were significantly associated with less fatigue (OR = 0.693; p = 0.0408). CONCLUSION: Higher serum uric acid levels were associated with TD motor subtype and less fatigue in early PD, which could be related to its anti-oxidative properties. Uric acid could be an important biomarker for specific motor features and symptoms of fatigue in PD.
OBJECTIVE:Uric acid has been found to be potentially neuroprotective in Parkinson's disease (PD). We investigated the relationship between serum uric acid levels and both motor and non-motor features in a prospective early PD cohort study. METHODS: Fasting serum uric acid levels were measured from 125 early PDpatients. Demographic, clinical characteristics, motor and non-motor assessments were performed. Patients were categorized into three motor subtypes: tremor-dominant (TD), postural instability/gait difficulty (PIGD), and mixed. Non-motor symptoms were classified as present or absent based on the appropriate cut-offs for each non-motor instrument. RESULTS: Most patients had TD (n = 51, 40.8%) and mixed (n = 63, 50.4%) motor subtypes, while a minority had PIGD (n = 11, 8.8%) motor subtype. The mean serum uric acid levels were significantly different between the three motor subtypes (p = 0.0106), with the mixed subtype having the lowest serum uric acid levels. Using the TD subtype as reference, patients with higher serum uric acid levels were less likely to have the mixed (OR = 0.684; p = 0.0312) subtype as opposed to the TD subtype. Uric acid levels were not significantly different between the TD and PIGD subtypes. For non-motor symptoms, higher serum uric acid levels were significantly associated with less fatigue (OR = 0.693; p = 0.0408). CONCLUSION: Higher serum uric acid levels were associated with TD motor subtype and less fatigue in early PD, which could be related to its anti-oxidative properties. Uric acid could be an important biomarker for specific motor features and symptoms of fatigue in PD.
Authors: Débora Lanznaster; Charlotte Veyrat-Durebex; Patrick Vourc'h; Christian R Andres; Hélène Blasco; Philippe Corcia Journal: Genes (Basel) Date: 2020-05-11 Impact factor: 4.096
Authors: Xiqun Chen; Chizoba C Umeh; Robert E Tainsh; Danielle D Feng; Michael Maguire; Fuxing Zuo; Maryam Rahimian; Robert Logan; Xinliumei Wang; Alberto Ascherio; Eric A Macklin; Emmanuel S Buys; Michael A Schwarzschild Journal: EBioMedicine Date: 2018-11-08 Impact factor: 8.143