Natacha M De Genna1, Gale A Richardson2, Lidush Goldschmidt3, Nancy L Day4, Marie D Cornelius5. 1. University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic (WPIC), 3811 O'Hara Street, Pittsburgh, PA, 15213, USA. Electronic address: degennan@pitt.edu. 2. University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic (WPIC), 3811 O'Hara Street, Pittsburgh, PA, 15213, USA. Electronic address: gar@pitt.edu. 3. Western Psychiatric Institute and Clinic (WPIC) at University of Pittsburgh Medical Center (UPMC), 3811 O'Hara Street, Pittsburgh, PA, 15213, USA. Electronic address: lidush@pitt.edu. 4. University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic (WPIC), 3811 O'Hara Street, Pittsburgh, PA, 15213, USA. Electronic address: nday@pitt.edu. 5. University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic (WPIC), 3811 O'Hara Street, Pittsburgh, PA, 15213, USA. Electronic address: mdc1@pitt.edu.
Abstract
INTRODUCTION: Prenatal exposures to tobacco and cannabis are associated with combustible cigarette use. This study evaluated pathways from these prenatal exposures to adult electronic cigarette use. We tested whether there were indirect effects of these prenatal exposures via childhood behavior dysregulation, early tobacco use, and adolescent tobacco dependence. METHODS: Telephone interviews were conducted with 427 adult offspring (22-33 years old) from 3 prenatal cohorts with trimester-specific data on exposures to tobacco, alcohol, and cannabis. The offspring were 59% Black and 41% White (61% female). Prenatal exposures included quantity/frequency of tobacco, alcohol, and cannabis use by mothers during the first trimester. Using logistic regression and structural equation modeling, we examined the effects of gestational exposures on adult electronic cigarette use via early cigarette use (prior to age 14), controlling for covariates of combustible and electronic cigarette use. RESULTS: There were no effects of childhood behavioral dysregulation on electronic cigarette use. However, there was a significant indirect effect of prenatal exposures to tobacco and cannabis on electronic cigarette use via early adolescent combustible cigarette use and adolescent risk for tobacco dependence. CONCLUSIONS: One implication of these findings is that the inter-generational risk for tobacco use conferred via gestational exposures to tobacco and cannabis generalizes to novel products such as electronic cigarettes. These results have implications for public health, as more women use cannabis and co-use cigarettes and cannabis during pregnancy.
INTRODUCTION: Prenatal exposures to tobacco and cannabis are associated with combustible cigarette use. This study evaluated pathways from these prenatal exposures to adult electronic cigarette use. We tested whether there were indirect effects of these prenatal exposures via childhood behavior dysregulation, early tobacco use, and adolescent tobacco dependence. METHODS: Telephone interviews were conducted with 427 adult offspring (22-33 years old) from 3 prenatal cohorts with trimester-specific data on exposures to tobacco, alcohol, and cannabis. The offspring were 59% Black and 41% White (61% female). Prenatal exposures included quantity/frequency of tobacco, alcohol, and cannabis use by mothers during the first trimester. Using logistic regression and structural equation modeling, we examined the effects of gestational exposures on adult electronic cigarette use via early cigarette use (prior to age 14), controlling for covariates of combustible and electronic cigarette use. RESULTS: There were no effects of childhood behavioral dysregulation on electronic cigarette use. However, there was a significant indirect effect of prenatal exposures to tobacco and cannabis on electronic cigarette use via early adolescent combustible cigarette use and adolescent risk for tobacco dependence. CONCLUSIONS: One implication of these findings is that the inter-generational risk for tobacco use conferred via gestational exposures to tobacco and cannabis generalizes to novel products such as electronic cigarettes. These results have implications for public health, as more women use cannabis and co-use cigarettes and cannabis during pregnancy.
Authors: Jennifer L Pearson; Sara C Hitchman; Leonie S Brose; Linda Bauld; Allison M Glasser; Andrea C Villanti; Ann McNeill; David B Abrams; Joanna E Cohen Journal: Tob Control Date: 2017-06-17 Impact factor: 7.552
Authors: Kristen E Sonon; Gale A Richardson; Jack R Cornelius; Kevin H Kim; Nancy L Day Journal: Neurotoxicol Teratol Date: 2014-11-13 Impact factor: 3.763
Authors: S Patricia Chou; Tulshi D Saha; Haitao Zhang; W June Ruan; Boji Huang; Bridget F Grant; Carlos Blanco; Wilson Compton Journal: Drug Alcohol Depend Date: 2017-06-24 Impact factor: 4.492
Authors: Karin A Kasza; Bridget K Ambrose; Kevin P Conway; Nicolette Borek; Kristie Taylor; Maciej L Goniewicz; K Michael Cummings; Eva Sharma; Jennifer L Pearson; Victoria R Green; Annette R Kaufman; Maansi Bansal-Travers; Mark J Travers; Jonathan Kwan; Cindy Tworek; Yu-Ching Cheng; Ling Yang; Nikolas Pharris-Ciurej; Dana M van Bemmel; Cathy L Backinger; Wilson M Compton; Andrew J Hyland Journal: N Engl J Med Date: 2017-01-26 Impact factor: 91.245