Noah C Peeri1, Jordan H Creed1, Gabriella M Anic1, Reid C Thompson2, Jeffrey J Olson3, Renato V LaRocca4, Sajeel A Chowdhary5, John D Brockman6, Travis A Gerke1, L Burton Nabors7, Kathleen M Egan8. 1. Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa FL, 33612, USA. 2. Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA. 3. Department of Neurosurgery, Emory School of Medicine, Atlanta, GA 30322, USA. 4. Norton Cancer Institute, Louisville, KY 40202, USA. 5. Neuro-Oncology Program, Lynn Cancer Institute, 701 NW 13th Street, Boca Raton, FL 33486, USA. 6. University of Missouri Research Reactor, University of Missouri, Columbia, MO 65211, USA. 7. Neuro-oncology Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA. 8. Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa FL, 33612, USA. Electronic address: kathleen.egan@moffitt.org.
Abstract
BACKGROUND: Selenium is an essential trace element obtained through diet that plays a critical role in DNA synthesis and protection from oxidative damage. Selenium intake and polymorphisms in selenoproteins have been linked to the risk of certain cancers though data for glioma are sparse. METHODS: In a case-control study of glioma, we examined the associations of selenium in toenails and genetic variants in the selenoenzyme pathway with the risk of glioma and patient survival. A total of 423 genetic variants in 29 candidate genes in the selenoenzyme pathway were studied in 1547 glioma cases and 1014 healthy controls. Genetic associations were also examined in the UK Biobank cohort comprised of 313,868 persons with 322 incident glioma cases. Toenail selenium was measured in a subcohort of 300 glioma cases and 300 age-matched controls from the case-control study. RESULTS: None of the 423 variants studied were consistently associated with glioma risk in the case-control and cohort studies. Moreover, toenail selenium in the case-control study had no significant association with glioma risk (p trend = 0.70) or patient survival among 254 patients with high grade tumors (p trend = 0.70). CONCLUSION: The present study offers no support for the hypothesis that selenium plays a role in the onset of glioma or patient outcome.
BACKGROUND: Selenium is an essential trace element obtained through diet that plays a critical role in DNA synthesis and protection from oxidative damage. Selenium intake and polymorphisms in selenoproteins have been linked to the risk of certain cancers though data for glioma are sparse. METHODS: In a case-control study of glioma, we examined the associations of selenium in toenails and genetic variants in the selenoenzyme pathway with the risk of glioma and patient survival. A total of 423 genetic variants in 29 candidate genes in the selenoenzyme pathway were studied in 1547 glioma cases and 1014 healthy controls. Genetic associations were also examined in the UK Biobank cohort comprised of 313,868 persons with 322 incident glioma cases. Toenail selenium was measured in a subcohort of 300 glioma cases and 300 age-matched controls from the case-control study. RESULTS: None of the 423 variants studied were consistently associated with glioma risk in the case-control and cohort studies. Moreover, toenail selenium in the case-control study had no significant association with glioma risk (p trend = 0.70) or patient survival among 254 patients with high grade tumors (p trend = 0.70). CONCLUSION: The present study offers no support for the hypothesis that selenium plays a role in the onset of glioma or patient outcome.
Authors: Rebecca B Little; L Burt Nabors; Jeffrey J Olson; Zachary J Thompson; Carrie M Rozmeski; Renato V LaRocca; Peter A Forsyth; Reid C Thompson; Robert A Oster; Sajeel A Chowdhary; Kathleen M Egan Journal: Cancer Causes Control Date: 2017-03-04 Impact factor: 2.506
Authors: Quinn T Ostrom; Luc Bauchet; Faith G Davis; Isabelle Deltour; James L Fisher; Chelsea Eastman Langer; Melike Pekmezci; Judith A Schwartzbaum; Michelle C Turner; Kyle M Walsh; Margaret R Wrensch; Jill S Barnholtz-Sloan Journal: Neuro Oncol Date: 2014-07 Impact factor: 12.300
Authors: Rebecca B Little; Melissa H Madden; Reid C Thompson; Jeffrey J Olson; Renato V Larocca; Edward Pan; James E Browning; Kathleen M Egan; L Burton Nabors Journal: Cancer Causes Control Date: 2013-03-03 Impact factor: 2.506
Authors: Martha L Slattery; Abbie Lundgreen; Bill Welbourn; Christopher Corcoran; Roger K Wolff Journal: PLoS One Date: 2012-05-17 Impact factor: 3.240