Rebecca B Little1, L Burt Nabors2, Jeffrey J Olson3, Zachary J Thompson4, Carrie M Rozmeski4, Renato V LaRocca5, Peter A Forsyth6, Reid C Thompson7, Robert A Oster8, Sajeel A Chowdhary9, Kathleen M Egan10. 1. Department of Nutrition Sciences, University of Alabama at Birmingham, Webb 449, 1675 University Blvd., Birmingham, AL, 35294, USA. 2. Neuro-oncology Program, University of Alabama at Birmingham, FOT 1020, 510 20th St. South, Birmingham, AL, 35294, USA. 3. Department of Neurosurgery, Emory University School of Medicine, 1365-B Clifton Rd., NE, Ste. 2200, Atlanta, GA, 30322, USA. 4. Division of Population Sciences, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA. 5. Department of Hematology-Oncology, Norton Cancer Institute, 676 So Floyd St., Louisville, KY, 40202, USA. 6. Department of Neuro-oncology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA. 7. Department of Neurological Surgery, Vanderbilt University Medical Center, 691 Preston Building, Nashville, TN, 37232, USA. 8. Department of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, MT 642, 1717 11th Ave. South, Birmingham, AL, 35205, USA. 9. Neuro-Oncology Program, Lynn Cancer Institute, 701 NW 13th Street, Boca Raton, FL, 33486, USA. 10. Division of Population Sciences, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA. Kathleen.egan@moffitt.org.
Abstract
PURPOSE: To examine the association of age when adult height was attained with glioma risk. METHODS: We analyzed data from a US-based case-control study of glioma risk factors. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) associated between age at attainment of adult height and glioma risk. Multivariate models were adjusted for age, race, sex, education, and state of residence. We examined associations overall, and according to glioma grade, sex, and final adult height. RESULTS: The study set included n = 951 controls and n = 776 cases, with a median age of 56 (18-92); the majority was male (53.8%) and identified as Caucasian. Older age at height completion was associated with an increased risk of glioma. A significant positive trend was observed both for glioblastoma (OR 1.10; 95% CI 1.04-1.17 per 1-year increase in age) and lower grade non-glioblastoma subtypes combined (OR 1.18; 95% CI 1.10-1.28 per year increase in age). The association was observed in men and women, and in all categories of final adult height. CONCLUSIONS: We observed for the first time a positive association between glioma risk and a prolonged adolescent growth phase. Our results suggest a role for factors governing the timing and intensity of growth in adolescence as risk-determining exposures in adult glioma.
PURPOSE: To examine the association of age when adult height was attained with glioma risk. METHODS: We analyzed data from a US-based case-control study of glioma risk factors. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) associated between age at attainment of adult height and glioma risk. Multivariate models were adjusted for age, race, sex, education, and state of residence. We examined associations overall, and according to glioma grade, sex, and final adult height. RESULTS: The study set included n = 951 controls and n = 776 cases, with a median age of 56 (18-92); the majority was male (53.8%) and identified as Caucasian. Older age at height completion was associated with an increased risk of glioma. A significant positive trend was observed both for glioblastoma (OR 1.10; 95% CI 1.04-1.17 per 1-year increase in age) and lower grade non-glioblastoma subtypes combined (OR 1.18; 95% CI 1.10-1.28 per year increase in age). The association was observed in men and women, and in all categories of final adult height. CONCLUSIONS: We observed for the first time a positive association between glioma risk and a prolonged adolescent growth phase. Our results suggest a role for factors governing the timing and intensity of growth in adolescence as risk-determining exposures in adult glioma.
Authors: Bhuma Krishnamachari; Dora Il'yasova; Michael E Scheurer; Melissa L Bondy; Margaret Wrensch; Faith G Davis Journal: Cancer Causes Control Date: 2014-06-03 Impact factor: 2.506
Authors: Michael B Cook; Michael Gamborg; Julie Aarestrup; Thorkild I A Sørensen; Jennifer L Baker Journal: Cancer Epidemiol Biomarkers Prev Date: 2013-10-02 Impact factor: 4.254
Authors: Steven C Moore; Preetha Rajaraman; Robert Dubrow; Amy S Darefsky; Corinna Koebnick; Albert Hollenbeck; Arthur Schatzkin; Michael F Leitzmann Journal: Cancer Res Date: 2009-10-06 Impact factor: 12.701
Authors: Melissa Z Braganza; Cari M Kitahara; Amy Berrington de González; Peter D Inskip; Kimberly J Johnson; Preetha Rajaraman Journal: Neuro Oncol Date: 2012-09-05 Impact factor: 12.300
Authors: Sara Wirén; Christel Häggström; Hanno Ulmer; Jonas Manjer; Tone Bjørge; Gabriele Nagel; Dorthe Johansen; Göran Hallmans; Anders Engeland; Hans Concin; Håkan Jonsson; Randi Selmer; Steinar Tretli; Tanja Stocks; Pär Stattin Journal: Cancer Causes Control Date: 2013-10-31 Impact factor: 2.506
Authors: Quinn T Ostrom; Kathleen M Egan; L Burt Nabors; Travis Gerke; Reid C Thompson; Jeffrey J Olson; Renato LaRocca; Sajeel Chowdhary; Jeanette E Eckel-Passow; Georgina Armstrong; John K Wiencke; Jonine L Bernstein; Elizabeth B Claus; Dora Il'yasova; Christoffer Johansen; Daniel H Lachance; Rose K Lai; Ryan T Merrell; Sara H Olson; Siegal Sadetzki; Joellen M Schildkraut; Sanjay Shete; Richard S Houlston; Robert B Jenkins; Margaret R Wrensch; Beatrice Melin; Christopher I Amos; Jason T Huse; Jill S Barnholtz-Sloan; Melissa L Bondy Journal: Int J Cancer Date: 2019-04-22 Impact factor: 7.396
Authors: Briana Miller; Noah C Peeri; Louis Burt Nabors; Jordan H Creed; Zachary J Thompson; Carrie M Rozmeski; Renato V LaRocca; Sajeel Chowdhary; Jeffrey J Olson; Reid C Thompson; Kathleen M Egan Journal: J Neurooncol Date: 2018-01-13 Impact factor: 4.130
Authors: Noah C Peeri; Jordan H Creed; Gabriella M Anic; Reid C Thompson; Jeffrey J Olson; Renato V LaRocca; Sajeel A Chowdhary; John D Brockman; Travis A Gerke; L Burton Nabors; Kathleen M Egan Journal: Cancer Epidemiol Date: 2018-05-25 Impact factor: 2.984