Aiqun Lin1, Wenxia Zheng1, Yan He2, Wenli Tang2, Xiaobo Wei3, Rongni He1, Wei Huang1, Yuying Su1, Yaowei Huang4, Hongwei Zhou5, Huifang Xie6. 1. Department of Neurology, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue Middle, Guangzhou City, Guangdong Province, 510282, PR China. 2. State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue Middle, Guangzhou City, Guangdong Province, 510282, PR China. 3. Department of Neurology, Neurological Research Lab, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue Middle, Guangzhou City, Guangdong Province, 510282, PR China. 4. Department of Neurology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou City, Guangdong Province, 510515, PR China. 5. State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue Middle, Guangzhou City, Guangdong Province, 510282, PR China. Electronic address: biodegradation@gmail.com. 6. Department of Neurology, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue Middle, Guangzhou City, Guangdong Province, 510282, PR China. Electronic address: xhffhx@126.com.
Abstract
INTRODUCTION: Accumulating evidence has revealed alterations in the communication between the gut and brain in patients with Parkinson's disease (PD), and previous studies have confirmed that alterations in the gut microbiome play an important role in the pathogenesis of numerous diseases, including PD. The aim of this study was to determine whether the faecal microbiome of PD patients in southern China differs from that of control subjects and whether the gut microbiome composition alters among different PD motor phenotypes. METHODS: We compared the gut microbiota composition of 75 patients with PD and 45 age-matched controls using 16S rRNA next-generation-sequencing. RESULTS: We observed significant increases in the abundance of four bacterial families and significant decreases in the abundance of seventeen bacterial families in patients with PD compared to those of the controls. In particular, the abundance of Lachnospiraceae was reduced by 42.9% in patients with PD, whereas Bifidobacteriaceae was enriched in patients with PD. We did not identify a significant difference in the overall microbial composition among different PD motor phenotypes, but we identified the association between specific taxas and different PD motor phenotypes. CONCLUSIONS: PD is accompanied by alterations in the abundance of specific gut microbes. The abundance of certain gut microbes was altered depending on clinical motor phenotypes. Based on our findings, the gut microbiome may be a potential PD biomarker.
INTRODUCTION: Accumulating evidence has revealed alterations in the communication between the gut and brain in patients with Parkinson's disease (PD), and previous studies have confirmed that alterations in the gut microbiome play an important role in the pathogenesis of numerous diseases, including PD. The aim of this study was to determine whether the faecal microbiome of PDpatients in southern China differs from that of control subjects and whether the gut microbiome composition alters among different PD motor phenotypes. METHODS: We compared the gut microbiota composition of 75 patients with PD and 45 age-matched controls using 16S rRNA next-generation-sequencing. RESULTS: We observed significant increases in the abundance of four bacterial families and significant decreases in the abundance of seventeen bacterial families in patients with PD compared to those of the controls. In particular, the abundance of Lachnospiraceae was reduced by 42.9% in patients with PD, whereas Bifidobacteriaceae was enriched in patients with PD. We did not identify a significant difference in the overall microbial composition among different PD motor phenotypes, but we identified the association between specific taxas and different PD motor phenotypes. CONCLUSIONS:PD is accompanied by alterations in the abundance of specific gut microbes. The abundance of certain gut microbes was altered depending on clinical motor phenotypes. Based on our findings, the gut microbiome may be a potential PD biomarker.
Authors: Zachary D Wallen; Mary Appah; Marissa N Dean; Cheryl L Sesler; Stewart A Factor; Eric Molho; Cyrus P Zabetian; David G Standaert; Haydeh Payami Journal: NPJ Parkinsons Dis Date: 2020-06-12
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