Literature DB >> 29775108

High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis in Head and Neck Squamous Carcinoma.

Lingeng Lu1, Gongjian Zhu2, Hongmei Zeng3, Qian Xu4, Klaus Holzmann5.   

Abstract

NSUN2 is a tRNA methyltransferase and plays an important role in cell development via modifying RNA methylation. We aimed to evaluate the expression of NSUN2 and its prognostic value in HNSCC. Random-effects model of meta-analysis shows 1.99-folds (95% CI: 1.89-2.09) upregulation of NSUN2 expression in HNSCC versus normal tissues. Patients with high NSUN2 levels had approximately 22 months shorter overall survival, and had a higher mortality risk than those with low one (p-trend = 0.020). In conclusion, NSUN2 is a potential independent prognostic marker and may be a potential therapeutic target in HNSCC.

Entities:  

Keywords:  HNSCC; NUSN2; RNA modification-associated gene; prognosis

Mesh：

Substances：

Year:  2018        PMID： 29775108     DOI： 10.1080/07357907.2018.1466896

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


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