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Literature DB >> 2977422

Phosphofructokinase activity in fibroblasts from patients with Alzheimer's disease and age- and sex-matched controls.

Abstract

The activity of the enzyme phosphofructokinase (PFK) was comparable in cultured skin fibroblasts from eight patients with Alzheimer's disease and eight age- and sex-matched controls. Mean activities were similar in the two groups whether measured under nonallosteric conditions at pH 8.0 or under allosteric conditions at pH 7.0, in the presence of 0.1 or 1 mM ATP. Activities of PFK in Alzheimer's disease and control cells also showed a similar temperature dependence and similar isozyme patterns on column chromatography. These results argue against the existence of significant structural variations of PFK in Alzheimer's disease.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1986 PMID： 2977422 DOI： 10.1007/bf00998479

Source DB: PubMed Journal: Metab Brain Dis ISSN： 0885-7490 Impact factor: 3.584

20 in total

1. THE RELATIONSHIPS BETWEEN SUBSTRATES AND ENZYMES OF GLYCOLYSIS IN BRAIN.

Authors: O H LOWRY; J V PASSONNEAU
Journal: J Biol Chem Date: 1964-01 Impact factor: 5.157

2. Altered calcium uptake in cultured skin fibroblasts from patients with Alzheimer's disease.

Authors: C Peterson; G E Gibson; J P Blass
Journal: N Engl J Med Date: 1985-04-18 Impact factor: 91.245

3. Alzheimer's disease. A metabolic systems degeneration?

Authors: J P Blass; A Zemcov
Journal: Neurochem Pathol Date: 1984

4. Computed tomography and positron emission transaxial tomography evaluations of normal aging and Alzheimer's disease.

Authors: M J de Leon; S H Ferris; A E George; B Reisberg; D R Christman; I I Kricheff; A P Wolf
Journal: J Cereb Blood Flow Metab Date: 1983-09 Impact factor: 6.200

5. Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system.

Authors: S Vora; C Seaman; S Durham; S Piomelli
Journal: Proc Natl Acad Sci U S A Date: 1980-01 Impact factor: 11.205

6. Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system.

Authors: S Vora
Journal: Blood Date: 1981-04 Impact factor: 22.113

7. Metabolic processes in Alzheimer's disease: adenine nucleotide content and production of 14CO2 from [U-14C]glucose in vitro in human neocortex.

Authors: N R Sims; D M Bowen; D Neary; A N Davison
Journal: J Neurochem Date: 1983-11 Impact factor: 5.372

8. [14C]acetylcholine synthesis and [14C]carbon dioxide production from [U-14C]glucose by tissue prisms from human neocortex.

Authors: N R Sims; D M Bowen; A N Davison
Journal: Biochem J Date: 1981-06-15 Impact factor: 3.857

9. Muscle phosphofructokinase deficiency. Biochemical and immunological studies of phosphofructokinase isozymes in muscle culture.

Authors: M Davidson; A F Miranda; A N Bender; S DiMauro; S Vora
Journal: J Clin Invest Date: 1983-08 Impact factor: 14.808