A Boggild1, J Brophy2, P Charlebois3, M Crockett4, J Geduld5, W Ghesquiere6, P McDonald7, P Plourde8, P Teitelbaum9, M Tepper10, S Schofield11, A McCarthy12. 1. University Health Network, Toronto General Hospital (Toronto, ON). 2. Division of Infectious Diseases, Children's Hospital of Eastern Ontario (Ottawa, ON). 3. Internal Medicine, Canadian Forces Health Services Centre (Atlantic) (Halifax, NS). 4. Paediatrics and Child Health, University of Manitoba (Winnipeg, MB). 5. Infectious Disease Prevention and Control Branch, Public Health Agency of Canada (Ottawa, ON). 6. Infectious Diseases and Internal Medicine, University of British Columbia (Victoria, BC). 7. Therapeutic Products Directorate, Health Canada (Ottawa, ON). 8. Faculty of Medicine, University of Manitoba (Winnipeg, MB). 9. Riverside Travel Medicine Clinic (Ottawa, ON). 10. Communicable Disease Control Program, Directorate of Force Health Protection (Ottawa, ON). 11. Pest Management Entomology, Directorate of Forces Health Protection (Ottawa, ON). 12. Tropical Medicine and International Health Clinic, Division of Infectious Disease, Ottawa Hospital General Campus (Ottawa, ON).
Abstract
BACKGROUND: On behalf of the Public Health Agency of Canada, the Committee to Advise on Tropical Medicine and Travel (CATMAT) developed the Canadian Recommendations for the Prevention and Treatment of Malaria Among International Travellers for Canadian health care providers who are preparing patients for travel to malaria-endemic areas and treating travellers who have returned ill. These recommendations aim to achieve appropriate diagnosis and management of malaria, a disease that is still uncommon in Canada. OBJECTIVE: To provide recommendations on the appropriate diagnosis and treatment of malaria. METHODS: CATMAT reviewed all major sources of information on malaria diagnosis and treatment, as well as recent research and national and international epidemiological data, to tailor guidelines to the Canadian context. The evidence-based medicine recommendations were developed with associated rating scales for the strength and quality of the evidence. RECOMMENDATIONS: Malarial management depends on rapid identification of the disease, as well as identification of the malaria species and level of parasitemia. Microscopic identification of blood samples is both rapid and accurate but can be done only by trained laboratory technicians. Rapid diagnostic tests are widely available, are simple to use and do not require specialized laboratory equipment or training; however, they do not provide the level of parasitemia and do require verification. Polymerase chain reaction (PCR), although still limited in availability, is emerging as the gold standard for high sensitivity and specificity in identifying the species.
BACKGROUND: On behalf of the Public Health Agency of Canada, the Committee to Advise on Tropical Medicine and Travel (CATMAT) developed the Canadian Recommendations for the Prevention and Treatment of Malaria Among International Travellers for Canadian health care providers who are preparing patients for travel to malaria-endemic areas and treating travellers who have returned ill. These recommendations aim to achieve appropriate diagnosis and management of malaria, a disease that is still uncommon in Canada. OBJECTIVE: To provide recommendations on the appropriate diagnosis and treatment of malaria. METHODS: CATMAT reviewed all major sources of information on malaria diagnosis and treatment, as well as recent research and national and international epidemiological data, to tailor guidelines to the Canadian context. The evidence-based medicine recommendations were developed with associated rating scales for the strength and quality of the evidence. RECOMMENDATIONS: Malarial management depends on rapid identification of the disease, as well as identification of the malaria species and level of parasitemia. Microscopic identification of blood samples is both rapid and accurate but can be done only by trained laboratory technicians. Rapid diagnostic tests are widely available, are simple to use and do not require specialized laboratory equipment or training; however, they do not provide the level of parasitemia and do require verification. Polymerase chain reaction (PCR), although still limited in availability, is emerging as the gold standard for high sensitivity and specificity in identifying the species.
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Authors: A Boggild; J Brophy; P Charlebois; M Crockett; J Geduld; W Ghesquiere; P McDonald; P Plourde; P Teitelbaum; M Tepper; S Schofield; A McCarthy Journal: Can Commun Dis Rep Date: 2014-04-03
Authors: A Boggild; J Brophy; P Charlebois; M Crockett; J Geduld; W Ghesquiere; P McDonald; P Plourde; P Teitelbaum; M Tepper; S Schofield; A McCarthy Journal: Can Commun Dis Rep Date: 2014-05-15
Authors: Michael T Hawkes; Sarah Forgie; Jason Brophy; Maryanne Crockett Journal: Can J Infect Dis Med Microbiol Date: 2015 Sep-Oct Impact factor: 2.471