Literature DB >> 29760129

Pharmacokinetic Changes during Pregnancy According to Genetic Variants: a Prospective Study in HIV-Infected Patients Receiving Atazanavir-Ritonavir.

Emanuele Focà1, Andrea Calcagno2, Andrea Bonito3, Jessica Cusato2, Elisabetta Domenighini3, Antonio D'Avolio2, Eugenia Quiros Roldan3, Laura Trentini2, Filippo Castelnuovo3, Giovanni Di Perri2, Francesco Castelli3, Stefano Bonora2.   

Abstract

Atazanavir-ritonavir concentrations change over time during pregnancy in HIV-positive patients; the impact of genetic variants is unknown. Twenty patients were enrolled in this study; plasma and intracellular concentrations of antiretrovirals were measured, in addition to single-nucleotide polymorphisms in transport-related genes. Linear logistic regression showed that genetic variants in organic-anion-transporter-1B1- and pregnane-X-receptor-encoding genes affected third-trimester atazanavir exposure. In this prospective study, genetic variants partially explained the observed interpatient variability in third-trimester exposure to antiretrovirals.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  HIV; antiretroviral agents; antiviral pharmacology

Mesh：

Substances：

Year:  2018        PMID： 29760129      PMCID： PMC6021630          DOI： 10.1128/AAC.00309-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

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