Pourya Arbab Jafari1, Hossein Ayatollahi1, Ramin Sadeghi2, Maryam Sheikhi3, Amir Asghari4. 1. a Department of Hematology and Blood Banking, Faculty of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran. 2. b Department of Nuclear Medicine, Faculty of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran. 3. c Cancer Molecular Pathology Research Center, Faculty of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran. 4. d Department of Physiology, Faculty of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran.
Abstract
OBJECTIVE: Serine/arginine-rich splicing factor 2 (SRSF2) mutations were detected frequently in myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) patients. However, its prognostic value has not yet been fully clarified. METHODS: In this meta-analysis, Hazard Ratio (HR) and 95% confidence interval (CI) for overall-survival (OS) were chosen to evaluate the prognostic impact of SRSF2 mutations and to compare SRSF2 mutations to those with wild-type. RESULTS: A total of 2056 patients from 12 studies were obtained. The pooled HRs for OSsuggested that patients with MDS had a poorer prognosis (HR = 1.780, 95% CI (1.410-2.249)), while analysis on SRSF2 mutations revealed no significant effect on the prognosis of CMML patients (HR = 1.091, 95% CI (0.925-1.286)). The frequency of SRSF2 mutations was found to be 11.5% and 39.8% in patients with MDS and CMML, respectively. DISCUSSION: This meta-analysis suggests that SRSF2 has a poor prognosis in patients with MDS, but no prognosis impact on patients with CMML. CONCLUSION: In conclusion, SRSF2 mutations were significantly related to the shorter OS in patients with MDS which may consider as an adverse prognostic risk factor. Whereas, analysis did not show any prognostic effect on OS of CMML patients with SRSF2 mutations.
OBJECTIVE:Serine/arginine-rich splicing factor 2 (SRSF2) mutations were detected frequently in myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) patients. However, its prognostic value has not yet been fully clarified. METHODS: In this meta-analysis, Hazard Ratio (HR) and 95% confidence interval (CI) for overall-survival (OS) were chosen to evaluate the prognostic impact of SRSF2 mutations and to compare SRSF2 mutations to those with wild-type. RESULTS: A total of 2056 patients from 12 studies were obtained. The pooled HRs for OSsuggested that patients with MDS had a poorer prognosis (HR = 1.780, 95% CI (1.410-2.249)), while analysis on SRSF2 mutations revealed no significant effect on the prognosis of CMMLpatients (HR = 1.091, 95% CI (0.925-1.286)). The frequency of SRSF2 mutations was found to be 11.5% and 39.8% in patients with MDS and CMML, respectively. DISCUSSION: This meta-analysis suggests that SRSF2 has a poor prognosis in patients with MDS, but no prognosis impact on patients with CMML. CONCLUSION: In conclusion, SRSF2 mutations were significantly related to the shorter OS in patients with MDS which may consider as an adverse prognostic risk factor. Whereas, analysis did not show any prognostic effect on OS of CMMLpatients with SRSF2 mutations.
Authors: Matilde Y Follo; Andrea Pellagatti; Richard N Armstrong; Stefano Ratti; Sara Mongiorgi; Sara De Fanti; Maria Teresa Bochicchio; Domenico Russo; Marco Gobbi; Maurizio Miglino; Sarah Parisi; Giovanni Martinelli; Michele Cavo; Donata Luiselli; James A McCubrey; Pann-Ghill Suh; Lucia Manzoli; Jacqueline Boultwood; Carlo Finelli; Lucio Cocco Journal: Leukemia Date: 2019-02-20 Impact factor: 11.528