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Literature DB >> 2975541

IL-2 production in the autologous mixed lymphocyte reaction of patients with juvenile rheumatoid arthritis.

K Oen¹, R Warrington, A M Rosenberg, D Krzekotowska.

Abstract

Interleukin 2 (IL-2) production in the CD4/non-T cell autologous mixed lymphocyte reaction (AMLR) was estimated for patients with juvenile rheumatoid arthritis (JRA). A cellular IL-2 assay (CILA) consisting of co-cultures of indicator cells, CTLL-2, added to CD4/non-T cell AMLR cultures was used. As both CD4 and CTLL-2 cell proliferation are IL-2 dependent, results of the CILA assay were taken as a reflection of the total IL-2 in the co-culture. By this assay most patients with JRA had normal IL-2 production. However, five patients with polyarticular disease had both a low AMLR and low levels of IL-2 production. Three of those tested showed little improvement in the AMLR on addition of recombinant IL-2, suggesting decreased responsiveness to IL-2 as well.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Interleukin-2

Year: 1988 PMID： 2975541 PMCID： PMC1541695

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

28 in total

1. T cell growth factor: parameters of production and a quantitative microassay for activity.

Authors: S Gillis; M M Ferm; W Ou; K A Smith
Journal: J Immunol Date: 1978-06 Impact factor: 5.422

2. HLA-DR antigens render resting T cells sensitive to interleukin-2 and induce production of the growth factor in the autologous mixed lymphocyte reaction.

Authors: R Palacios; G Möller
Journal: Cell Immunol Date: 1981-09-01 Impact factor: 4.868

3. Heterogeneity of human T4+ inducer T cells defined by a monoclonal antibody that delineates two functional subpopulations.

Authors: E L Reinherz; C Morimoto; K A Fitzgerald; R E Hussey; J F Daley; S F Schlossman
Journal: J Immunol Date: 1982-01 Impact factor: 5.422

4. Responder cells in the human autologous mixed lymphocyte reaction.

Authors: J S Smolen; T A Luger; T M Chused; A D Steinberg
Journal: J Clin Invest Date: 1981-12 Impact factor: 14.808

5. Reactivity of inducer cell subsets and T8-cell activation during the human autologous mixed lymphocyte reaction.

Authors: P L Romain; C Morimoto; J F Daley; L S Palley; E L Reinherz; S F Schlossman
Journal: Clin Immunol Immunopathol Date: 1984-01

Review 6. Autologous mixed lymphocyte reaction in health and disease states in man.

Authors: S Gupta
Journal: Vox Sang Date: 1983 Impact factor: 2.144

7. A defect in the suppressor circuits among OKT4+ cell populations in patients with systemic lupus erythematosus occurs independently of a defect in the OKT8+ suppressor T cell function.

Authors: T Sakane; H Kotani; S Takada; Y Murakawa; Y Ueda
Journal: J Immunol Date: 1983-08 Impact factor: 5.422

8. Dissection of immunoregulatory subpopulations of T lymphocytes within the helper and suppressor sublineages in man.

Authors: P A Gatenby; G S Kansas; C Y Xian; R L Evans; E G Engleman
Journal: J Immunol Date: 1982-11 Impact factor: 5.422

9. Detection of activated T cell products in the rheumatoid joint using cDNA probes to Interleukin-2 (IL-2) IL-2 receptor and IFN-gamma.

Authors: G Buchan; K Barrett; T Fujita; T Taniguchi; R Maini; M Feldmann
Journal: Clin Exp Immunol Date: 1988-02 Impact factor: 4.330

10. Human autologous mixed lymphocyte reactivity is primarily specific for xenoprotein determinants adsorbed to antigen-presenting cells during rosette formation with sheep erythrocytes.

Authors: C Huber; M Merkenschlager; C Gattringer; I Royston; U Fink; H Braunsteiner
Journal: J Exp Med Date: 1982-04-01 Impact factor: 14.307

3 in total