Literature DB >> 6459343

Responder cells in the human autologous mixed lymphocyte reaction.

J S Smolen, T A Luger, T M Chused, A D Steinberg.   

Abstract

Isolated human T4+ cells proliferate in the autologous mixed lymphocyte reaction (AMLR), whereas isolated T8+ cells do not. However, in the presence of Interleukin 2 or T4+ cells, the T8+ cells demonstrated substantial proliferation. These studies suggest that T8+ cells recognize signals from autologous non-T cells, but require an additional factor for the subsequent proliferative response. Since this stimulus can be provided by T4+ cells, the AMLR appears to constitute an inducer circuit. Different defects in this circuit may be responsible for the common abnormality of the AMLR in different diseases.

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Year:  1981        PMID： 6459343      PMCID： PMC370966          DOI： 10.1172/jci110416

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  16 in total

1.  Specificity and suppressor function of human T cells responsive to autologous non-T cells.

Authors:  T Sakane; I Green
Journal:  J Immunol       Date:  1979-08       Impact factor: 5.422

2.  Separation of functional subsets of human T cells by a monoclonal antibody.

Authors:  E L Reinherz; P C Kung; G Goldstein; S F Schlossman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

Review 3.  T-cell growth factor and the culture of cloned functional T cells.

Authors:  K A Smith; F W Ruscetti
Journal:  Adv Immunol       Date:  1981       Impact factor: 3.543

4.  Activation of suppressor T cells in human autologous mixed lymphocyte culture.

Authors:  J B Smith; R P Knowlton
Journal:  J Immunol       Date:  1979-07       Impact factor: 5.422

5.  Failure of autologous mixed lymphocyte reactions between T and non-T cells in patients with systemic lupus erythematosus.

Authors:  T Sakane; A D Steinberg; I Green
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

6.  Autologous mixed lymphocyte reaction in patients with Hodgkin's disease. Evidence for a T cell defect.

Authors:  E G Engleman; C J Benike; R T Hoppe; H S Kaplan; F R Berberich
Journal:  J Clin Invest       Date:  1980-07       Impact factor: 14.808

7.  Specificity and function of a human autologous reactive T cell.

Authors:  P B Hausman; J D Stobo
Journal:  J Exp Med       Date:  1979-06-01       Impact factor: 14.307

8.  Lymphocyte transformation induced by autologous cells. V. Generation of immunologic memory and specificity during the autologous mixed lymphocyte reaction.

Authors:  M E Weksler; R Kozak
Journal:  J Exp Med       Date:  1977-12-01       Impact factor: 14.307

9.  Autologous stimulation of human lymphocyte subpopulation.

Authors:  G Opelz; M Kiuchi; M Takasugi; P I Terasaki
Journal:  J Exp Med       Date:  1975-11-01       Impact factor: 14.307

10.  Induction of polyclonal antibody synthesis by human allogeneic and autologous helper factors.

Authors:  N Chiorazzi; S M Fu; H G Kunkel
Journal:  J Exp Med       Date:  1979-06-01       Impact factor: 14.307
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  20 in total

1.  Impaired autologous mixed lymphocyte reaction (AMLR) reactivity of peripheral blood T cell subsets in rheumatoid arthritis.

Authors:  E C Keystone; L Poplonski; K M Snow; M Martell
Journal:  Clin Exp Immunol       Date:  1989-11       Impact factor: 4.330

2.  A defect in immunoregulatory synovial fluid T cells in Behçet's syndrome.

Authors:  J Alcocer-Varela; A Laffon; C Abud-Mendoza; D Alarcon-Segovia
Journal:  Clin Rheumatol       Date:  1989-03       Impact factor: 2.980

3.  OKT4+ and OKT8+ T lymphocytes produce soluble factors that can modulate growth and differentiation of human B cells.

Authors:  T Sakane; Y Ueda; N Suzuki; Y Niwa; T Hoshino; T Tsunematsu
Journal:  Clin Exp Immunol       Date:  1985-10       Impact factor: 4.330

4.  Activation of immune regulatory circuits among OKT4+ cells by autologous mixed lymphocyte reactions.

Authors:  H Kotani; S Takada; Y Ueda; Y Murakawa; N Suzuki; T Sakane
Journal:  Clin Exp Immunol       Date:  1984-05       Impact factor: 4.330

5.  Impairment of the autologous mixed lymphocyte reaction in atopic dermatitis.

Authors:  D Y Leung; J A Saryan; R Frankel; M Lareau; R S Geha
Journal:  J Clin Invest       Date:  1983-10       Impact factor: 14.808

6.  Immunological studies of autoimmune thyroid disorders: abnormalities in the inducer T cell subset and proliferative responses to autologous and allogeneic stimulation.

Authors:  C Fournier; H Chen; A Leger; J Charreire
Journal:  Clin Exp Immunol       Date:  1983-11       Impact factor: 4.330

7.  Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

Authors:  S C Meuer; S F Schlossman; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

8.  Relationship between systemic lupus erythematosus T cell subsets, anti-T cell antibodies, and T cell functions.

Authors:  C Morimoto; E L Reinherz; J A Distaso; A D Steinberg; S F Schlossman
Journal:  J Clin Invest       Date:  1984-03       Impact factor: 14.808

9.  Increased peripheral blood Ia positive T cells and their effect on autologous mixed lymphocyte reaction in chronic active liver disease.

Authors:  K Fukui; S Kakumu; H Murakami; J Kuriki; K Yoshioka; N Sakamoto
Journal:  Clin Exp Immunol       Date:  1984-10       Impact factor: 4.330

10.  Interleukin-2 activity in chronic active liver diseases: response by T cells and in the autologous mixed lymphocyte reaction.

Authors:  K Yoshioka; S Kakumu; H Murakami; K Fukui
Journal:  Clin Exp Immunol       Date:  1984-06       Impact factor: 4.330
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