Yung-Sung Lee1, Lai-Chu See2, Shu-Hao Chang3, Nan-Kai Wang4, Yih-Shiou Hwang4, Chi-Chun Lai4, Kuan-Jen Chen4, Wei-Chi Wu5. 1. Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan. 2. Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Public Health, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Biostatistics Core Laboratory, Molecular Medicine Research Centre, Chang Gung University, Taoyuan, Taiwan. 3. Department of Public Health, College of Medicine, Chang Gung University, Taoyuan, Taiwan. 4. Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. 5. Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address: weichi666@gmail.com.
Abstract
PURPOSE: To investigate the macular structures, optical components, and visual acuity in preschool-aged children with a history of type I retinopathy of prematurity who underwent either intravitreal bevacizumab (IVB), laser, or a combination of treatments. DESIGN: Comparative interventional case series. METHODS: Setting: A referred medical center in Taiwan. STUDY POPULATION: Eighty eyes from 42 patients (33 IVB-treated eyes from 17 children, 24 laser-treated eyes from 13 children, and 23 laser + IVB-treated eyes from 12 children). OBSERVATION PROCEDURE: Spectral-domain optical coherence tomography. MAIN OUTCOME MEASURES: The retinal thickness in the foveal area and the associated morphologic changes in foveal depression. RESULTS: Compared with the laser-treated and laser + IVB-treated eyes, the IVB-treated eyes had less myopia and deeper anterior chamber depths but presented similar axial lengths and corneal curvatures (P = .001, P = .002, P = .95, and P = .16, respectively). The IVB-treated eyes had significantly thinner foveal, parafoveal, and perifoveal retinal thicknesses (P < .01 for all) and a higher incidence of foveal depression than the laser- or laser + IVB-treated eyes. The macular and subfoveal choroidal thicknesses did not differ among the groups (P = .21 and P = .63, respectively). Moreover, compared with the eyes treated with laser or laser + IVB, the IVB-treated eyes had better uncorrected visual acuity, although a significant difference was not observed in best-corrected visual acuity (P = .008 and P = .29, respectively). CONCLUSIONS: Compared with laser therapy, IVB-treated eyes were associated with deeper anterior chamber depths and thinner foveal, parafoveal, and perifoveal thicknesses. Moreover, these IVB-treated eyes had fewer refractive errors and better uncorrected visual acuity.
PURPOSE: To investigate the macular structures, optical components, and visual acuity in preschool-aged children with a history of type I retinopathy of prematurity who underwent either intravitreal bevacizumab (IVB), laser, or a combination of treatments. DESIGN: Comparative interventional case series. METHODS: Setting: A referred medical center in Taiwan. STUDY POPULATION: Eighty eyes from 42 patients (33 IVB-treated eyes from 17 children, 24 laser-treated eyes from 13 children, and 23 laser + IVB-treated eyes from 12 children). OBSERVATION PROCEDURE: Spectral-domain optical coherence tomography. MAIN OUTCOME MEASURES: The retinal thickness in the foveal area and the associated morphologic changes in foveal depression. RESULTS: Compared with the laser-treated and laser + IVB-treated eyes, the IVB-treated eyes had less myopia and deeper anterior chamber depths but presented similar axial lengths and corneal curvatures (P = .001, P = .002, P = .95, and P = .16, respectively). The IVB-treated eyes had significantly thinner foveal, parafoveal, and perifoveal retinal thicknesses (P < .01 for all) and a higher incidence of foveal depression than the laser- or laser + IVB-treated eyes. The macular and subfoveal choroidal thicknesses did not differ among the groups (P = .21 and P = .63, respectively). Moreover, compared with the eyes treated with laser or laser + IVB, the IVB-treated eyes had better uncorrected visual acuity, although a significant difference was not observed in best-corrected visual acuity (P = .008 and P = .29, respectively). CONCLUSIONS: Compared with laser therapy, IVB-treated eyes were associated with deeper anterior chamber depths and thinner foveal, parafoveal, and perifoveal thicknesses. Moreover, these IVB-treated eyes had fewer refractive errors and better uncorrected visual acuity.
Authors: Emily Wiecek; James D Akula; Deborah K Vanderveen; Iason S Mantagos; Carolyn Wu; Amber-Lee Curran; Hanna De Bruyn; Bridget Peterson; Anne B Fulton Journal: Am J Ophthalmol Date: 2022-03-31 Impact factor: 5.488
Authors: Michael Simmons; Jingyun Wang; Joel N Leffler; Shanshan Li; Sarah E Morale; Angie de la Cruz; Eileen E Birch Journal: Transl Vis Sci Technol Date: 2021-04-01 Impact factor: 3.283