Literature DB >> 29752801

In vivo super-resolution imaging of transient retinal phototropism evoked by oblique light stimulation.

Yiming Lu1, Changgeng Liu1, Xincheng Yao1,2.   

Abstract

Rod-dominated transient retinal phototropism (TRP) has been observed in freshly isolated retinas, promising a noninvasive biomarker for objective assessment of retinal physiology. However, in vivo mapping of TRP is challenging due to its subcellular signal magnitude and fast time course. We report here a virtually structured detection-based super-resolution ophthalmoscope to achieve subcellular spatial resolution and millisecond temporal resolution for in vivo imaging of TRP. Spatiotemporal properties of in vivo TRP were characterized corresponding to variable light intensity stimuli, confirming that TRP is tightly correlated with early stages of phototransduction.

Entities:  

Keywords:  functional imaging; ophthalmoscopy; photoreceptor; retina; super-resolution microscopy

Mesh：

Year:  2018        PMID： 29752801      PMCID： PMC5946809          DOI： 10.1117/1.JBO.23.5.050502

Source DB:  PubMed          Journal:  J Biomed Opt        ISSN： 1083-3668            Impact factor:   3.170


  21 in total

1.  Dynamic near-infrared imaging reveals transient phototropic change in retinal rod photoreceptors.

Authors:  Rongwen Lu; Alexander M Levy; Qiuxiang Zhang; Steven J Pittler; Xincheng Yao
Journal:  J Biomed Opt       Date:  2013-10       Impact factor: 3.170

2.  Line-field parallel swept source MHz OCT for structural and functional retinal imaging.

Authors:  Daniel J Fechtig; Branislav Grajciar; Tilman Schmoll; Cedric Blatter; Rene M Werkmeister; Wolfgang Drexler; Rainer A Leitgeb
Journal:  Biomed Opt Express       Date:  2015-02-04       Impact factor: 3.732

3.  Stimulus-evoked outer segment changes occur before the hyperpolarization of retinal photoreceptors.

Authors:  Yiming Lu; Benquan Wang; David R Pepperberg; Xincheng Yao
Journal:  Biomed Opt Express       Date:  2016-12-02       Impact factor: 3.732

4.  In vivo super-resolution retinal imaging through virtually structured detection.

Authors:  Changgeng Liu; Yanan Zhi; Benquan Wang; Damber Thapa; Yanjun Chen; Minhaj Alam; Yiming Lu; Xincheng Yao
Journal:  J Biomed Opt       Date:  2016-12-01       Impact factor: 3.170

5.  Comparison of Visual Function in Older Eyes in the Earliest Stages of Age-related Macular Degeneration to Those in Normal Macular Health.

Authors:  Cynthia Owsley; Carrie Huisingh; Mark E Clark; Gregory R Jackson; Gerald McGwin
Journal:  Curr Eye Res       Date:  2015-03-24       Impact factor: 2.424

6.  Functional optical coherence tomography reveals transient phototropic change of photoreceptor outer segments.

Authors:  Benquan Wang; Qiuxiang Zhang; Rongwen Lu; Yanan Zhi; Xincheng Yao
Journal:  Opt Lett       Date:  2014-12-15       Impact factor: 3.776

7.  Long-term follow-up of retinitis pigmentosa patients with multifocal electroretinography.

Authors:  Ditta Nagy; Birgitt Schönfisch; Eberhart Zrenner; Herbert Jägle
Journal:  Invest Ophthalmol Vis Sci       Date:  2008-06-19       Impact factor: 4.799

8.  In vivo confocal intrinsic optical signal identification of localized retinal dysfunction.

Authors:  Qiu-Xiang Zhang; Rong-Wen Lu; Christine A Curcio; Xin-Cheng Yao
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-12-13       Impact factor: 4.799

Review 9.  Photoreceptor degeneration and dysfunction in aging and age-related maculopathy.

Authors:  Gregory R Jackson; Cynthia Owsley; Christine A Curcio
Journal:  Ageing Res Rev       Date:  2002-06       Impact factor: 10.895

10.  Functional optical coherence tomography enables in vivo physiological assessment of retinal rod and cone photoreceptors.

Authors:  Qiuxiang Zhang; Rongwen Lu; Benquan Wang; Jeffrey D Messinger; Christine A Curcio; Xincheng Yao
Journal:  Sci Rep       Date:  2015-04-22       Impact factor: 4.379
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  6 in total

Review 1.  Fast intrinsic optical signal correlates with activation phase of phototransduction in retinal photoreceptors.

Authors:  Xincheng Yao; Tae-Hoon Kim
Journal:  Exp Biol Med (Maywood)       Date:  2020-06-19

Review 2.  Functional optical coherence tomography of retinal photoreceptors.

Authors:  Xincheng Yao; Taeyoon Son; Tae-Hoon Kim; Yiming Lu
Journal:  Exp Biol Med (Maywood)       Date:  2018-11-27

3.  Light-Induced Length Shrinkage of Rod Photoreceptor Outer Segments.

Authors:  Yiming Lu; Jacopo Benedetti; Xincheng Yao
Journal:  Transl Vis Sci Technol       Date:  2018-12-21       Impact factor: 3.283

4.  Virtually structured detection enables super-resolution ophthalmoscopy of rod and cone photoreceptors in human retina.

Authors:  Yiming Lu; Taeyoon Son; Tae-Hoon Kim; David Le; Xincheng Yao
Journal:  Quant Imaging Med Surg       Date:  2021-03

Review 5.  Super-resolution ophthalmoscopy: Virtually structured detection for resolution improvement in retinal imaging.

Authors:  Xincheng Yao; Rongwen Lu; Benquan Wang; Yiming Lu; Tae-Hoon Kim
Journal:  Exp Biol Med (Maywood)       Date:  2020-11-27

Review 6.  Functional Optical Coherence Tomography for Intrinsic Signal Optoretinography: Recent Developments and Deployment Challenges.

Authors:  Tae-Hoon Kim; Guangying Ma; Taeyoon Son; Xincheng Yao
Journal:  Front Med (Lausanne)       Date:  2022-04-04
  6 in total

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