Thaïs Baert1, Joke Van Camp2, Lisa Vanbrabant2, Pieter Busschaert3, Annouschka Laenen4, Sileny Han3, Els Van Nieuwenhuysen3, Ignace Vergote5, An Coosemans6. 1. Department of Oncology, Laboratory of Tumor Immunology and Immunotherapy, ImmunOvar Research Group, KU Leuven, Leuven Cancer Institute, Leuven, Belgium; Department of Gynecology and Obstetrics, UZ Leuven, Leuven, Belgium. 2. Department of Oncology, Laboratory of Tumor Immunology and Immunotherapy, ImmunOvar Research Group, KU Leuven, Leuven Cancer Institute, Leuven, Belgium. 3. Department of Gynecology and Obstetrics, UZ Leuven, Leuven, Belgium. 4. Biostatistics and Statistical Bioinformatics Center of Leuven, KU Leuven, Leuven, Belgium. 5. Department of Oncology, Laboratory of Tumor Immunology and Immunotherapy, ImmunOvar Research Group, KU Leuven, Leuven Cancer Institute, Leuven, Belgium; Department of Gynecology and Obstetrics, UZ Leuven, Leuven, Belgium; Department of Oncology, Laboratory of Gynecologic Oncology, ImmunOvar Research Group, KU Leuven, Leuven Cancer Institute, Leuven, Belgium. 6. Department of Oncology, Laboratory of Tumor Immunology and Immunotherapy, ImmunOvar Research Group, KU Leuven, Leuven Cancer Institute, Leuven, Belgium; Department of Gynecology and Obstetrics, UZ Leuven, Leuven, Belgium. Electronic address: an.coosemans@gmail.com.
Abstract
OBJECTIVE: The effect of CA125, neutrophil to lymphocyte ratio (NLR) and thrombocytosis on survival has been studied in ovarian cancer. This study explores the link between these variables and serum markers of ovarian cancer patients, such as signaling proteins and cytokines. METHODS: Serum samples of 39 patients with high-grade serous ovarian cancer (HGSOC) were collected at diagnosis and were retrospectively analysed for clinical characteristics, clinical parameters (NLR, CA125, platelet count) and immune profile [IL-4 (interleukin), IL-10, IL-13, IL-17, transforming growth factor-β, Arginase-1, Interferon gamma), vascular endothelial growth factor (VEGF), galectin-1 and chemokine (C-C) motif ligand 2. RESULTS: CA125 correlates negatively with VEGF (p = 0.02) and if CA125 rises above 500 kU/L, IL-10 is significantly increased (p = 0.01). NLR > 6 (p < 0.01) was significantly correlated with decreased overall survival. Thrombocytosis was significantly correlated with IL-10 (p < 0.01) and a platelet count > 400 × 109/l led to an improvement in progression free survival (p < 0.01). CONCLUSIONS: A correlation, at the time of diagnosis, of HGSOC between CA125, NLR and thrombocytes and an immunosuppressive cytokine-profile in serum is shown, and correlates with survival.
OBJECTIVE: The effect of CA125, neutrophil to lymphocyte ratio (NLR) and thrombocytosis on survival has been studied in ovarian cancer. This study explores the link between these variables and serum markers of ovarian cancerpatients, such as signaling proteins and cytokines. METHODS: Serum samples of 39 patients with high-grade serous ovarian cancer (HGSOC) were collected at diagnosis and were retrospectively analysed for clinical characteristics, clinical parameters (NLR, CA125, platelet count) and immune profile [IL-4 (interleukin), IL-10, IL-13, IL-17, transforming growth factor-β, Arginase-1, Interferon gamma), vascular endothelial growth factor (VEGF), galectin-1 and chemokine (C-C) motif ligand 2. RESULTS:CA125 correlates negatively with VEGF (p = 0.02) and if CA125 rises above 500 kU/L, IL-10 is significantly increased (p = 0.01). NLR > 6 (p < 0.01) was significantly correlated with decreased overall survival. Thrombocytosis was significantly correlated with IL-10 (p < 0.01) and a platelet count > 400 × 109/l led to an improvement in progression free survival (p < 0.01). CONCLUSIONS: A correlation, at the time of diagnosis, of HGSOC between CA125, NLR and thrombocytes and an immunosuppressive cytokine-profile in serum is shown, and correlates with survival.
Authors: Claudia Marchetti; Marco D'Indinosante; Carolina Bottoni; Chiara Di Ilio; Stefano Di Berardino; Barbara Costantini; Angelo Minucci; Laura Vertechy; Giovanni Scambia; Anna Fagotti Journal: Sci Rep Date: 2021-05-27 Impact factor: 4.379
Authors: Dong Soo Suh; Yong Jung Song; Hyun-Jin Roh; Sang Hun Lee; Dae Hoon Jeong; Tae Hwa Lee; Kyung Un Choi; Ki Hyung Kim Journal: Cancer Manag Res Date: 2021-06-24 Impact factor: 3.989