Bruno Ramos Chrcanovic1, Carolina Cavalieri Gomes2, Ricardo Santiago Gomez3. 1. Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden. 2. Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 3. Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Abstract
PURPOSE: To review all available data published on central giant cell lesion (CGCL) of the jaws into a comprehensive analysis of its clinical/radiological features, with emphasis on the predictive factors associated with its recurrence. METHODS: An electronic search was undertaken in 5 databases (February/2018), looking for reporting cases of CGCLs. RESULTS: A total of 365 publications were included, comprising 2270 lesions. CGCLs were more prevalent in women and the mandible. Cortical bone perforation occurred in 50% of the cases. Marginal/segmental resection was more often performed in larger lesions, and drug therapy was more frequent in small lesions. Recurrence was reported in 232 of 1316 cases (17.6%). The recurrence rate of the aggressive lesions (22.8%) after surgical treatment was higher than non-aggressive lesions (7.8%). Four of 5 CGCLs showed partial/total regression with pharmacological treatment. Aggressive lesions showed a worse response to corticosteroids than non-aggressive lesions. For the lesions submitted to surgery as the first treatment, curettage, enucleation, or marginal resection in relation to segmental resection, aggressive lesions, cortical bone perforation, and tooth root resorption were associated with increased recurrence rate. Recurrence related to a combination of surgical/pharmacological treatment could not be evaluated due to the variety of protocols. CONCLUSIONS: Aggressive CGCLs recur more often than the non-aggressive ones. Despite sometimes showing poor response to corticosteroid injection or surgical curettage, a combination of both treatment strategies should be considered in aggressive cases to reduce morbidities associated with radical surgery. The best protocol to manage aggressive and non-aggressive lesions remains to be determined.
PURPOSE: To review all available data published on central giant cell lesion (CGCL) of the jaws into a comprehensive analysis of its clinical/radiological features, with emphasis on the predictive factors associated with its recurrence. METHODS: An electronic search was undertaken in 5 databases (February/2018), looking for reporting cases of CGCLs. RESULTS: A total of 365 publications were included, comprising 2270 lesions. CGCLs were more prevalent in women and the mandible. Cortical bone perforation occurred in 50% of the cases. Marginal/segmental resection was more often performed in larger lesions, and drug therapy was more frequent in small lesions. Recurrence was reported in 232 of 1316 cases (17.6%). The recurrence rate of the aggressive lesions (22.8%) after surgical treatment was higher than non-aggressive lesions (7.8%). Four of 5 CGCLs showed partial/total regression with pharmacological treatment. Aggressive lesions showed a worse response to corticosteroids than non-aggressive lesions. For the lesions submitted to surgery as the first treatment, curettage, enucleation, or marginal resection in relation to segmental resection, aggressive lesions, cortical bone perforation, and tooth root resorption were associated with increased recurrence rate. Recurrence related to a combination of surgical/pharmacological treatment could not be evaluated due to the variety of protocols. CONCLUSIONS: Aggressive CGCLs recur more often than the non-aggressive ones. Despite sometimes showing poor response to corticosteroid injection or surgical curettage, a combination of both treatment strategies should be considered in aggressive cases to reduce morbidities associated with radical surgery. The best protocol to manage aggressive and non-aggressive lesions remains to be determined.
Authors: Yoon Ji Jina Rhou; Che-Jen Wang; Minh Nguyen; Joel A Vanderniet; Craig F Munns; Hedley Coleman; James Kim; Deborah Jane Holmes-Walker; Lydia Lim; Christian M Girgis Journal: Calcif Tissue Int Date: 2022-01-28 Impact factor: 4.333
Authors: Carolina Cavalieri Gomes; Tenzin Gayden; Andrea Bajic; Osama F Harraz; Jonathan Pratt; Hamid Nikbakht; Eric Bareke; Marina Gonçalves Diniz; Wagner Henriques Castro; Pascal St-Onge; Daniel Sinnett; HyeRim Han; Barbara Rivera; Leonie G Mikael; Nicolas De Jay; Claudia L Kleinman; Elvis Terci Valera; Angelia V Bassenden; Albert M Berghuis; Jacek Majewski; Mark T Nelson; Ricardo Santiago Gomez; Nada Jabado Journal: Nat Commun Date: 2018-11-01 Impact factor: 14.919
Authors: Aviel Ragamin; Carolina C Gomes; Nada Jabado; Grazia Maria Simonetta Mancini; Ricardo Santiago Gomez; Karen Bindels-de Heus; Renata Sandoval; Angelia V Bassenden; Luciano Dib; Fernando Kok; Julieta Alves; Irene Mathijssen; Evita Medici-Van den Herik; Robert Eveleigh; Tenzin Gayden; Bas Pullens; Albert Berghuis; Marjon van Slegtenhorst; Martina Wilke Journal: J Med Genet Date: 2021-03-08 Impact factor: 6.318