Reinhard E Friedrich1, Hanna A Scheuer2. 1. Department of Oral and Craniomaxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany; rfriedrich@uke.de. 2. Department of Orthodontics, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.
Abstract
BACKGROUND: Noonan syndrome (NS) is a multigenic disorder with a highly variable phenotype. Cardiac disorders and a predisposition to neoplasm often require early medical attention. Central giant central lesions (CGCLs) of the jaws are part of the phenotype. CASE REPORT: In a patient with genetically confirmed NS and multiple teeth loss presumably caused by CGCL, careful review of the medical history and radiographic findings made it probable that the cause of tooth loss was cervical root resorption (CRR) of the teeth following long-term orthodontic therapy. CONCLUSION: CRR is a rare dental disease of unknown origin. However, association with prior orthodontic therapy is well documented. In NS, mandibular lesions can occur which, at first glance, might lead the examiner to assume that it is a CGCL, but on closer analysis, obviously are of non-tumorous origin and should be assessed as coincidental. The report adds relevant information to orthodontic treatment of NS patients.
BACKGROUND: Noonan syndrome (NS) is a multigenic disorder with a highly variable phenotype. Cardiac disorders and a predisposition to neoplasm often require early medical attention. Central giant central lesions (CGCLs) of the jaws are part of the phenotype. CASE REPORT: In a patient with genetically confirmed NS and multiple teeth loss presumably caused by CGCL, careful review of the medical history and radiographic findings made it probable that the cause of tooth loss was cervical root resorption (CRR) of the teeth following long-term orthodontic therapy. CONCLUSION: CRR is a rare dental disease of unknown origin. However, association with prior orthodontic therapy is well documented. In NS, mandibular lesions can occur which, at first glance, might lead the examiner to assume that it is a CGCL, but on closer analysis, obviously are of non-tumorous origin and should be assessed as coincidental. The report adds relevant information to orthodontic treatment of NS patients.
Authors: Avi Shemesh; Avi Levin; Joe Ben Itzhak; Yair Brosh; Evgeny Braverman; Gabriel Batashvili; Michael Solomonov Journal: Aust Endod J Date: 2018-08-20 Impact factor: 1.659
Authors: Carolina C Gomes; Marina G Diniz; Victor C Bastos; Vanessa F Bernardes; Ricardo S Gomez Journal: J Pathol Date: 2019-12-18 Impact factor: 7.996
Authors: Karim Kouz; Christina Lissewski; Stephanie Spranger; Diana Mitter; Angelika Riess; Vanesa Lopez-Gonzalez; Sabine Lüttgen; Hatip Aydin; Florian von Deimling; Christina Evers; Andreas Hahn; Maja Hempel; Ulrike Issa; Anne-Karin Kahlert; Adrian Lieb; Pablo Villavicencio-Lorini; Maria Juliana Ballesta-Martinez; Sheela Nampoothiri; Angela Ovens-Raeder; Alena Puchmajerová; Robin Satanovskij; Heide Seidel; Stephan Unkelbach; Bernhard Zabel; Kerstin Kutsche; Martin Zenker Journal: Genet Med Date: 2016-04-21 Impact factor: 8.822