Literature DB >> 29751000

2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain.

Marc P Baggelaar1, Mauro Maccarrone2, Mario van der Stelt3.   

Abstract

2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB1 receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. In this review, we describe the biosynthetic and metabolic pathways of 2-AG and how chemical and genetic perturbation of these pathways has led to insight in the biological role of this signaling lipid. Finally, we discuss the potential therapeutic benefits of modulating 2-AG levels in the brain.
Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Year:  2018        PMID： 29751000     DOI： 10.1016/j.plipres.2018.05.002

Source DB:  PubMed          Journal:  Prog Lipid Res        ISSN： 0163-7827            Impact factor:   16.195


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