Literature DB >> 29750084

Viral manipulation of host mRNA decay.

Liang Guo1,2,3, Irina Vlasova-St Louis1, Paul R Bohjanen1,4,2,3.   

Abstract

Viruses alter host-cell gene expression at many biochemical levels, such as transcription, translation, mRNA splicing and mRNA decay in order to create a cellular environment suitable for viral replication. In this review, we discuss mechanisms by which viruses manipulate host-gene expression at the level of mRNA decay in order to enable the virus to evade host antiviral responses to allow viral survival and replication. We discuss different cellular RNA decay pathways, including the deadenylation-dependent mRNA decay pathway, and various strategies that viruses exploit to manipulate these pathways in order to create a virus-friendly cellular environment.

Entities:  

Keywords:  cis-acting elements; host mRNA decay; virus

Year:  2018        PMID: 29750084      PMCID: PMC5939598          DOI: 10.2217/fvl-2017-0106

Source DB:  PubMed          Journal:  Future Virol        ISSN: 1746-0794            Impact factor:   1.831


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