| Literature DB >> 29750084 |
Liang Guo1,2,3, Irina Vlasova-St Louis1, Paul R Bohjanen1,4,2,3.
Abstract
Viruses alter host-cell gene expression at many biochemical levels, such as transcription, translation, mRNA splicing and mRNA decay in order to create a cellular environment suitable for viral replication. In this review, we discuss mechanisms by which viruses manipulate host-gene expression at the level of mRNA decay in order to enable the virus to evade host antiviral responses to allow viral survival and replication. We discuss different cellular RNA decay pathways, including the deadenylation-dependent mRNA decay pathway, and various strategies that viruses exploit to manipulate these pathways in order to create a virus-friendly cellular environment.Entities:
Keywords: cis-acting elements; host mRNA decay; virus
Year: 2018 PMID: 29750084 PMCID: PMC5939598 DOI: 10.2217/fvl-2017-0106
Source DB: PubMed Journal: Future Virol ISSN: 1746-0794 Impact factor: 1.831