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Literature DB >> 29749411

A dual-function fluorescent probe for monitoring the degrees of hypoxia in living cells via the imaging of nitroreductase and adenosine triphosphate.

Yu Fang¹, Wen Shi, Yiming Hu, Xiaohua Li, Huimin Ma.

Abstract

A new dual-function fluorescent probe is developed for detecting nitroreductase (NTR) and adenosine triphosphate (ATP) with different responses. Imaging application of the probe reveals that intracellular NTR and ATP display an adverse changing trend during a hypoxic process and ATP can serve as a new sign for cell hypoxia.

Entities: Chemical Disease

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Year: 2018 PMID： 29749411 DOI： 10.1039/c8cc02209g

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

9 in total

Review 1. State-of-the-art: functional fluorescent probes for bioimaging and pharmacological research.

Authors: Lu Lu; Zhou-Yue Wu; Xin Li; Feng Han
Journal: Acta Pharmacol Sin Date: 2018-11-28 Impact factor: 6.150

Review 2. Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids.

Authors: Joana Krämer; Rui Kang; Laura M Grimm; Luisa De Cola; Pierre Picchetti; Frank Biedermann
Journal: Chem Rev Date: 2022-01-07 Impact factor: 60.622

3. An Activatable Near-Infrared Chromophore for Multispectral Optoacoustic Imaging of Tumor Hypoxia and for Tumor Inhibition.

Authors: Jing Huang; Yinglong Wu; Fang Zeng; Shuizhu Wu
Journal: Theranostics Date: 2019-09-25 Impact factor: 11.556

4. Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5'-triphosphate in Cellular Applications.

Authors: Luling Wu; Jihong Liu; Xue Tian; Robin R Groleau; Beidou Feng; Yonggang Yang; Adam C Sedgwick; Hai-Hao Han; Yang Wang; Han-Min Wang; Fang Huang; Steven D Bull; Hua Zhang; Chusen Huang; Yi Zang; Jia Li; Xiao-Peng He; Ping Li; Bo Tang; Tony D James; Jonathan L Sessler
Journal: J Am Chem Soc Date: 2021-12-21 Impact factor: 15.419

5. Novel designed azo substituted semi-cyanine fluorescent probe for cytochrome P450 reductase detection and hypoxia imaging in cancer cells.

Authors: Caiyue Wang; Shuping Zhang; Junhai Huang; Lei Cui; Jin Hu; Shaoying Tan
Journal: RSC Adv Date: 2019-07-11 Impact factor: 4.036

A dual-function fluorescent probe for monitoring the degrees of hypoxia in living cells via the imaging of nitroreductase and adenosine triphosphate.

Review 1. State-of-the-art: functional fluorescent probes for bioimaging and pharmacological research.

Review 2. Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids.

3. An Activatable Near-Infrared Chromophore for Multispectral Optoacoustic Imaging of Tumor Hypoxia and for Tumor Inhibition.

4. Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5'-triphosphate in Cellular Applications.

5. Novel designed azo substituted semi-cyanine fluorescent probe for cytochrome P450 reductase detection and hypoxia imaging in cancer cells.

6. Real-time optical imaging of the hypoxic status in hemangioma endothelial cells during propranolol therapy.

Review 7. Near-infrared fluorescent molecular probes for imaging and diagnosis of nephro-urological diseases.

8. From prodrug to pro-prodrug: hypoxia-sensitive antibody-drug conjugates.

9. A Nitronaphthalimide Probe for Fluorescence Imaging of Hypoxia in Cancer Cells.