Literature DB >> 2974922

Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter.

H Hug1, M Costas, P Staeheli, M Aebi, C Weissmann.   

Abstract

Specific resistance of Mx+ mice to influenza virus is due to the interferon (IFN)-induced protein Mx. The Mx gene consists of 14 exons that are spread over at least 55 kilobase pairs of DNA. Surprisingly, the Mx gene promoter is induced as efficiently by Newcastle disease virus as it is by IFN. The 5' boundary of the region required for maximal induction by both IFN and Newcastle disease virus is located about 140 base pairs upstream of the cap site. This region contains five elements of the type GAAANN, which occurs in all IFN- and virus-inducible promoters. The consensus sequence purine-GAAAN(N/-)GAAA(C/G)-pyrimidine is found in all IFN-inducible promoters.

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Year:  1988        PMID： 2974922      PMCID： PMC363533          DOI： 10.1128/mcb.8.8.3065-3079.1988

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  60 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  A new method for sequencing DNA.

Authors:  A M Maxam; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

3.  The primary structure of rabbit beta-globin mRNA as determined from cloned DNA.

Authors:  A Efstratiadis; F C Kafatos; T Maniatis
Journal:  Cell       Date:  1977-04       Impact factor: 41.582

4.  A simple method for DNA restriction site mapping.

Authors:  H O Smith; M L Birnstiel
Journal:  Nucleic Acids Res       Date:  1976-09       Impact factor: 16.971

5.  The 5'-flanking region of a human IFN-alpha gene mediates viral induction of transcription.

Authors:  U Weidle; C Weissmann
Journal:  Nature       Date:  1983 Jun 2-8       Impact factor: 49.962

6.  Sendai virus contains overlapping genes expressed from a single mRNA.

Authors:  C Giorgi; B M Blumberg; D Kolakofsky
Journal:  Cell       Date:  1983-12       Impact factor: 41.582

7.  Lambda replacement vectors carrying polylinker sequences.

Authors:  A M Frischauf; H Lehrach; A Poustka; N Murray
Journal:  J Mol Biol       Date:  1983-11-15       Impact factor: 5.469

8.  Structure and nucleotide sequence of the heavy chain gene of HLA-DR.

Authors:  H K Das; S K Lawrance; S M Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

9.  Mx-dependent resistance to influenza viruses is induced by mouse interferons alpha and beta but not gamma.

Authors:  P Staeheli; M A Horisberger; O Haller
Journal:  Virology       Date:  1984-01-30       Impact factor: 3.616

10.  Complete nucleotide sequence of a functional class I HLA gene, HLA-A3: implications for the evolution of HLA genes.

Authors:  T Strachan; R Sodoyer; M Damotte; B R Jordan
Journal:  EMBO J       Date:  1984-04       Impact factor: 11.598
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  81 in total

1.  Phosphorylation of the Stat1 transactivating domain is required for the response to type I interferons.

Authors:  Andreas Pilz; Katrin Ramsauer; Hamid Heidari; Michael Leitges; Pavel Kovarik; Thomas Decker
Journal:  EMBO Rep       Date:  2003-03-21       Impact factor: 8.807

2.  Molecular cloning of the pufferfish (Takifugu rubripes) Mx gene and functional characterization of its promoter.

Authors:  Wai Ho Yap; Alice Tay; Sydney Brenner; Byrappa Venkatesh
Journal:  Immunogenetics       Date:  2003-01-09       Impact factor: 2.846

3.  Differential regulation of HLA class I genes by interferon.

Authors:  H Schmidt; V Gekeler; H Haas; G Engler-Blum; I Steiert; H Probst; C A Müller
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846

4.  DNA protein interactions at the interferon-responsive promoter elements: potential for an H-DNA conformation.

Authors:  C Roy; B Lebleu
Journal:  Nucleic Acids Res       Date:  1991-02-11       Impact factor: 16.971

Review 5.  Disease resistance in farm animals.

Authors:  M Müller; G Brem
Journal:  Experientia       Date:  1991-09-15

6.  Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways.

Authors:  D J Lew; T Decker; J E Darnell
Journal:  Mol Cell Biol       Date:  1989-12       Impact factor: 4.272

7.  Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

Authors:  T Fujita; L F Reis; N Watanabe; Y Kimura; T Taniguchi; J Vilcek
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

8.  Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds.

Authors:  K D Khan; K Shuai; G Lindwall; S E Maher; J E Darnell; A L Bothwell
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205

9.  Recognition of distinct HLA-DQA1 promoter elements by a single nuclear factor containing Jun and Fos or antigenically related proteins.

Authors:  M Neve Ombra; M Autiero; A DeLerma Barbaro; R Barretta; G Del Pozzo; J Guardiola
Journal:  Nucleic Acids Res       Date:  1993-04-25       Impact factor: 16.971

10.  Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system.

Authors:  N Tanaka; T Kawakami; T Taniguchi
Journal:  Mol Cell Biol       Date:  1993-08       Impact factor: 4.272
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