Literature DB >> 6317203

Sendai virus contains overlapping genes expressed from a single mRNA.

C Giorgi, B M Blumberg, D Kolakofsky.   

Abstract

The mRNA coding for the Sendai virus P and C proteins was located on the viral genome using cloned DNA and the relevant regions of the DNA were sequenced. The nucleotide sequence revealed two overlapping open reading frames that could code for proteins of 568 and 204 amino acids. Primer extension and S1 nuclease mapping studies detected only a single 1.894 kb mRNA from this region. Hybrid arrest of translation studies using restriction fragments verified the overlapping nature of these genes. Sequence homologies at the beginning of three Sendai virus cistrons suggest that these genes may have arisen by duplication from a common ancestor, possibly an influenza-like virus gene.

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Year:  1983        PMID： 6317203     DOI： 10.1016/0092-8674(83)90115-0

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  99 in total

1.  Expression of the ORF-2 protein of the human respiratory syncytial virus M2 gene is initiated by a ribosomal termination-dependent reinitiation mechanism.

Authors:  G Ahmadian; J S Randhawa; A J Easton
Journal:  EMBO J       Date:  2000-06-01       Impact factor: 11.598

2.  Identification of a cis-acting element required for shunt-mediated translational initiation of the Sendai virus Y proteins.

Authors:  Sylvain de Breyne; Viviane Simonet; Thierry Pelet; Joseph Curran
Journal:  Nucleic Acids Res       Date:  2003-01-15       Impact factor: 16.971

3.  The nucleocapsid protein gene of bovine coronavirus is bicistronic.

Authors:  S D Senanayake; M A Hofmann; J L Maki; D A Brian
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

4.  Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes.

Authors:  M Kozak
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

5.  Characterization of the Tupaia rhabdovirus genome reveals a long open reading frame overlapping with P and a novel gene encoding a small hydrophobic protein.

Authors:  Christoph Springfeld; Gholamreza Darai; Roberto Cattaneo
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

6.  Editing of the Sendai virus P/C mRNA by G insertion occurs during mRNA synthesis via a virus-encoded activity.

Authors:  S Vidal; J Curran; D Kolakofsky
Journal:  J Virol       Date:  1990-01       Impact factor: 5.103

7.  Sendai virus protein-protein interactions studied by a protein-blotting protein-overlay technique: mapping of domains on NP protein required for binding to P protein.

Authors:  H E Homann; W Willenbrink; C J Buchholz; W J Neubert
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

8.  The P gene of human parainfluenza virus type 1 encodes P and C proteins but not a cysteine-rich V protein.

Authors:  Y Matsuoka; J Curran; T Pelet; D Kolakofsky; R Ray; R W Compans
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

9.  Ribosomal frameshifting during translation of measles virus P protein mRNA is capable of directing synthesis of a unique protein.

Authors:  P Liston; D J Briedis
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

10.  Complete sequences of the intergenic and mRNA start signals in the Sendai virus genome: homologies with the genome of vesicular stomatitis virus.

Authors:  K C Gupta; D W Kingsbury
Journal:  Nucleic Acids Res       Date:  1984-05-11       Impact factor: 16.971
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