| Literature DB >> 29748285 |
Ralph B Puchalski1,2, Nameeta Shah3,4, Jeremy Miller5, Rachel Dalley5, Steve R Nomura2, Jae-Guen Yoon2, Kimberly A Smith5, Michael Lankerovich2, Darren Bertagnolli5, Kris Bickley5, Andrew F Boe5, Krissy Brouner5, Stephanie Butler5, Shiella Caldejon5, Mike Chapin5, Suvro Datta5, Nick Dee5, Tsega Desta5, Tim Dolbeare5, Nadezhda Dotson5, Amanda Ebbert5, David Feng5, Xu Feng6, Michael Fisher5, Garrett Gee5, Jeff Goldy5, Lindsey Gourley5, Benjamin W Gregor5, Guangyu Gu5, Nika Hejazinia5, John Hohmann5, Parvinder Hothi2, Robert Howard5, Kevin Joines5, Ali Kriedberg5, Leonard Kuan5, Chris Lau5, Felix Lee5, Hwahyung Lee2, Tracy Lemon5, Fuhui Long5, Naveed Mastan5, Erika Mott5, Chantal Murthy2, Kiet Ngo5, Eric Olson5, Melissa Reding5, Zack Riley5, David Rosen5, David Sandman5, Nadiya Shapovalova5, Clifford R Slaughterbeck5, Andrew Sodt5, Graham Stockdale5, Aaron Szafer5, Wayne Wakeman5, Paul E Wohnoutka5, Steven J White7, Don Marsh7, Robert C Rostomily8,9, Lydia Ng5, Chinh Dang5, Allan Jones5, Bart Keogh6, Haley R Gittleman10, Jill S Barnholtz-Sloan10, Patrick J Cimino11, Megha S Uppin12, C Dirk Keene11, Farrokh R Farrokhi13, Justin D Lathia14, Michael E Berens15, Antonio Iavarone16,17,18, Amy Bernard5, Ed Lein5, John W Phillips5, Steven W Rostad19, Charles Cobbs2, Michael J Hawrylycz1, Greg D Foltz2.
Abstract
Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, and their relationships to histologic features routinely used for diagnosis are unclear. We present the Ivy Glioblastoma Atlas, an anatomically based transcriptional atlas of human glioblastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor. The atlas and its clinical and genomic database are freely accessible online data resources that will serve as a valuable platform for future investigations of glioblastoma pathogenesis, diagnosis, and treatment.Entities:
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Year: 2018 PMID： 29748285 PMCID： PMC6414061 DOI： 10.1126/science.aaf2666
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728