Literature DB >> 29748115

KRAS Activating Signaling Triggers Arteriovenous Malformations.

Feixiong Cheng1, Ruth Nussinov2.   

Abstract

The underlying genetic causes and altered signaling pathways of brain arteriovenous malformations remain unknown. A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)-ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  KRAS; KRAS4A; brain arteriovenous malformations; endothelial cells; somatic mutation

Mesh：

Substances：

Year:  2018        PMID： 29748115      PMCID： PMC6014919          DOI： 10.1016/j.tibs.2018.04.007

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  10 in total

1.  PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia.

Authors:  Laura A Jansen; Ghayda M Mirzaa; Gisele E Ishak; Brian J O'Roak; Joseph B Hiatt; William H Roden; Sonya A Gunter; Susan L Christian; Sarah Collins; Carissa Adams; Jean-Baptiste Rivière; Judith St-Onge; Jeffrey G Ojemann; Jay Shendure; Robert F Hevner; William B Dobyns
Journal:  Brain       Date:  2015-02-25       Impact factor: 13.501

2.  Delayed inhibition of VEGF signaling after stroke attenuates blood-brain barrier breakdown and improves functional recovery in a comorbidity-dependent manner.

Authors:  Patrick Reeson; Kelly A Tennant; Kim Gerrow; Josh Wang; Sammy Weiser Novak; Kelsey Thompson; Krista-Linn Lockhart; Andrew Holmes; Patrick C Nahirney; Craig E Brown
Journal:  J Neurosci       Date:  2015-04-01       Impact factor: 6.167

Review 3.  Structural causes of ischemic and hemorrhagic stroke in children: moyamoya and arteriovenous malformations.

Authors:  Edward R Smith
Journal:  Curr Opin Pediatr       Date:  2015-12       Impact factor: 2.856

4.  Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain.

Authors:  Sergey I Nikolaev; Sandra Vetiska; Ximena Bonilla; Emilie Boudreau; Suvi Jauhiainen; Behnam Rezai Jahromi; Nadiya Khyzha; Peter V DiStefano; Santeri Suutarinen; Tim-Rasmus Kiehl; Vitor Mendes Pereira; Alexander M Herman; Timo Krings; Hugo Andrade-Barazarte; Takyee Tung; Taufik Valiante; Gelareh Zadeh; Mike Tymianski; Tuomas Rauramaa; Seppo Ylä-Herttuala; Joshua D Wythe; Stylianos E Antonarakis; Juhana Frösen; Jason E Fish; Ivan Radovanovic
Journal:  N Engl J Med       Date:  2018-01-03       Impact factor: 91.245

Review 5.  Somatic mutation, genomic variation, and neurological disease.

Authors:  Annapurna Poduri; Gilad D Evrony; Xuyu Cai; Christopher A Walsh
Journal:  Science       Date:  2013-07-05       Impact factor: 47.728

Review 6.  Calmodulin and PI3K Signaling in KRAS Cancers.

Authors:  Ruth Nussinov; Guanqiao Wang; Chung-Jung Tsai; Hyunbum Jang; Shaoyong Lu; Avik Banerjee; Jian Zhang; Vadim Gaponenko
Journal:  Trends Cancer       Date:  2017-02-18

7.  Pulmonary Comorbidity in Lung Cancer.

Authors:  Feixiong Cheng; Joseph Loscalzo
Journal:  Trends Mol Med       Date:  2018-02-01       Impact factor: 11.951

8.  Stroke and Cancer- A Complicated Relationship.

Authors:  Jennifer L Dearborn; Victor C Urrutia; Steven R Zeiler
Journal:  J Neurol Transl Neurosci       Date:  2014

Review 9.  Brain arteriovenous malformations.

Authors:  Michael T Lawton; W Caleb Rutledge; Helen Kim; Christian Stapf; Kevin J Whitehead; Dean Y Li; Timo Krings; Karel terBrugge; Douglas Kondziolka; Michael K Morgan; Karam Moon; Robert F Spetzler
Journal:  Nat Rev Dis Primers       Date:  2015-05-28       Impact factor: 52.329

10.  Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.

Authors:  Siddhartha Jaiswal; Pradeep Natarajan; Alexander J Silver; Christopher J Gibson; Alexander G Bick; Eugenia Shvartz; Marie McConkey; Namrata Gupta; Stacey Gabriel; Diego Ardissino; Usman Baber; Roxana Mehran; Valentin Fuster; John Danesh; Philippe Frossard; Danish Saleheen; Olle Melander; Galina K Sukhova; Donna Neuberg; Peter Libby; Sekar Kathiresan; Benjamin L Ebert
Journal:  N Engl J Med       Date:  2017-06-21       Impact factor: 91.245
  10 in total
  3 in total

Review 1.  Personal Mutanomes Meet Modern Oncology Drug Discovery and Precision Health.

Authors:  Feixiong Cheng; Han Liang; Atul J Butte; Charis Eng; Ruth Nussinov
Journal:  Pharmacol Rev       Date:  2018-12-13       Impact factor: 25.468

2.  Metabolic Disorder of Extracellular Matrix Mediated by Decorin Upregulation Is Associated With Brain Arteriovenous Malformation Diffuseness.

Authors:  Maogui Li; Qingyuan Liu; Junhua Yang; Pengjun Jiang; Yi Yang; Yanan Zhang; Yong Cao; Jun Wu; Shuo Wang
Journal:  Front Aging Neurosci       Date:  2020-12-07       Impact factor: 5.750

3.  Cell-free DNA next-generation sequencing liquid biopsy as a new revolutionary approach for arteriovenous malformation.

Authors:  Maria Palmieri; Aurora Currò; Andrea Tommasi; Laura Di Sarno; Gabriella Doddato; Margheria Baldassarri; Elisa Frullanti; Ann Rita Giliberti; Chiara Fallerini; Angelo Spinazzola; Anna Maria Pinto; Alessandra Renieri; Massimo Vaghi
Journal:  JVS Vasc Sci       Date:  2020-09-02
  3 in total

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