Literature DB >> 29746832

Bacteriophage Transcription Factor Cro Regulates Virulence Gene Expression in Enterohemorrhagic Escherichia coli.

Juan D Hernandez-Doria1, Vanessa Sperandio2.   

Abstract

Bacteriophage-encoded genetic elements control bacterial biological functions. Enterohemorrhagic Escherichia coli (EHEC) strains harbor lambda-phages encoding the Shiga-toxin (Stx), which is expressed during the phage lytic cycle and associated with exacerbated disease. Phages also reside dormant within bacterial chromosomes through their lysogenic cycle, but how this impacts EHEC virulence remains unknown. We find that during lysogeny the phage transcription factor Cro activates the EHEC type III secretion system (T3SS). EHEC lambdoid phages are lysogenic under anaerobic conditions when Cro binds to and activates the promoters of T3SS genes. Interestingly, the Cro sequence varies among phages carried by different EHEC outbreak strains, and these changes affect Cro-dependent T3SS regulation. Additionally, infecting mice with the related pathogen C. rodentium harboring the bacteriophage cro from EHEC results in greater T3SS gene expression and enhanced virulence. Collectively, these findings reveal the role of phages in impacting EHEC virulence and their potential to affect outbreak strains.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Shiga toxin; bacteriophage; enterohemorrhagic E. coli (EHEC); gene regulation; locus of enterocyte effacement (LEE); pathogenicity islands

Mesh：

Substances：

Year:  2018        PMID： 29746832      PMCID： PMC5982111          DOI： 10.1016/j.chom.2018.04.007

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  56 in total

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