Yuning Gu1, Charlie Y Wang1, Christian E Anderson1, Yuchi Liu1, He Hu1, Mette L Johansen2, Dan Ma3, Yun Jiang3, Ciro Ramos-Estebanez4, Susann Brady-Kalnay3,5, Mark A Griswold1,3, Chris A Flask1,3,6, Xin Yu1,3,7. 1. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio. 2. Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio. 3. Department of Radiology, Case Western Reserve University, Cleveland, Ohio. 4. Department of Neurology, Case Western Reserve University, Cleveland, Ohio. 5. Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio. 6. Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio. 7. Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio.
Abstract
PURPOSE: The goal of this study was to develop a fast MR fingerprinting (MRF) method for simultaneous T1 and T2 mapping in DCE-MRI studies in mice. METHODS: The MRF sequences based on balanced SSFP and fast imaging with steady-state precession were implemented and evaluated on a 7T preclinical scanner. The readout used a zeroth-moment-compensated variable-density spiral trajectory that fully sampled the entire k-space and the inner 10 × 10 k-space with 48 and 4 interleaves, respectively. In vitro and in vivo studies of mouse brain were performed to evaluate the accuracy of MRF measurements with both fully sampled and undersampled data. The application of MRF to dynamic T1 and T2 mapping in DCE-MRI studies were demonstrated in a mouse model of heterotopic glioblastoma using gadolinium-based and dysprosium-based contrast agents. RESULTS: The T1 and T2 measurements in phantom showed strong agreement between the MRF and the conventional methods. The MRF with spiral encoding allowed up to 8-fold undersampling without loss of measurement accuracy. This enabled simultaneous T1 and T2 mapping with 2-minute temporal resolution in DCE-MRI studies. CONCLUSION: Magnetic resonance fingerprinting provides the opportunity for dynamic quantification of contrast agent distribution in preclinical tumor models on high-field MRI scanners.
PURPOSE: The goal of this study was to develop a fast MR fingerprinting (MRF) method for simultaneous T1 and T2 mapping in DCE-MRI studies in mice. METHODS: The MRF sequences based on balanced SSFP and fast imaging with steady-state precession were implemented and evaluated on a 7T preclinical scanner. The readout used a zeroth-moment-compensated variable-density spiral trajectory that fully sampled the entire k-space and the inner 10 × 10 k-space with 48 and 4 interleaves, respectively. In vitro and in vivo studies of mouse brain were performed to evaluate the accuracy of MRF measurements with both fully sampled and undersampled data. The application of MRF to dynamic T1 and T2 mapping in DCE-MRI studies were demonstrated in a mouse model of heterotopic glioblastoma using gadolinium-based and dysprosium-based contrast agents. RESULTS: The T1 and T2 measurements in phantom showed strong agreement between the MRF and the conventional methods. The MRF with spiral encoding allowed up to 8-fold undersampling without loss of measurement accuracy. This enabled simultaneous T1 and T2 mapping with 2-minute temporal resolution in DCE-MRI studies. CONCLUSION: Magnetic resonance fingerprinting provides the opportunity for dynamic quantification of contrast agent distribution in preclinical tumor models on high-field MRI scanners.
Authors: Peter Schmitt; Mark A Griswold; Peter M Jakob; Markus Kotas; Vikas Gulani; Michael Flentje; Axel Haase Journal: Magn Reson Med Date: 2004-04 Impact factor: 4.668
Authors: Alice C Yu; Chaitra Badve; Lee E Ponsky; Shivani Pahwa; Sara Dastmalchian; Matthew Rogers; Yun Jiang; Seunghee Margevicius; Mark Schluchter; William Tabayoyong; Robert Abouassaly; Debra McGivney; Mark A Griswold; Vikas Gulani Journal: Radiology Date: 2017-02-10 Impact factor: 11.105
Authors: Stephanie L Barnes; Anna G Sorace; Jennifer G Whisenant; J Oliver McIntyre; Hakmook Kang; Thomas E Yankeelov Journal: NMR Biomed Date: 2017-09-15 Impact factor: 4.044
Authors: Susan M Burden-Gulley; Theresa J Gates; Adam M Burgoyne; Jennifer L Cutter; David T Lodowski; Shenandoah Robinson; Andrew E Sloan; Robert H Miller; James P Basilion; Susann M Brady-Kalnay Journal: Neoplasia Date: 2010-04 Impact factor: 5.715
Authors: Brett Z Fite; Azadeh Kheirolomoom; Josquin L Foiret; Jai W Seo; Lisa M Mahakian; Elizabeth S Ingham; Sarah M Tam; Alexander D Borowsky; Fitz-Roy E Curry; Katherine W Ferrara Journal: J Control Release Date: 2017-04-07 Impact factor: 9.776
Authors: Yong Chen; Yun Jiang; Shivani Pahwa; Dan Ma; Lan Lu; Michael D Twieg; Katherine L Wright; Nicole Seiberlich; Mark A Griswold; Vikas Gulani Journal: Radiology Date: 2016-01-21 Impact factor: 11.105
Authors: Christian E Anderson; Shannon B Donnola; Yun Jiang; Joshua Batesole; Rebecca Darrah; Mitchell L Drumm; Susann M Brady-Kalnay; Nicole F Steinmetz; Xin Yu; Mark A Griswold; Chris A Flask Journal: Sci Rep Date: 2017-08-16 Impact factor: 4.379
Authors: Christian E Anderson; Mette Johansen; Bernadette O Erokwu; He Hu; Yuning Gu; Yifan Zhang; Michael Kavran; Jason Vincent; Mitchell L Drumm; Mark A Griswold; Nicole F Steinmetz; Ming Li; Heather Clark; Rebecca J Darrah; Xin Yu; Susann M Brady-Kalnay; Chris A Flask Journal: Sci Rep Date: 2019-12-27 Impact factor: 4.379