Mehmet Aksoy1, Ayşe Nur Aksoy2, Ali Ahıskalıoğlu1, İlker İnce1, Esra Laloğlu3, Ayşenur Dostbil1, Mine Gürsaç Çelik1. 1. Department of Anesthesiology and Reanimation, Atatürk University School of Medicine, Erzurum, Turkey. 2. Clinic of Obstetrics and Gynecology, Nenehatun Hospital, Erzurum, Turkey. 3. Department of Biochemistry, Atatürk University School of Medicine, Erzurum, Turkey.
Abstract
OBJECTIVE: Brain-derived neurotrophic factor (BDNF), a member of neurotrophins, plays a critical role in neuronal tissue. In this study, the effects of spinal or general anaesthesia on cord and maternal peripheral blood BDNF and malondialdehyde (MDA) levels were investigated in patients undergoing elective caesarean section. METHODS: Eighty patients with term pregnancy were included. General anaesthesia was induced with intravenous (IV) propofol 2 mg kg-1 in the general anaesthesia group (n=36). In the spinal anaesthesia group (n=35), hyperbaric bupivacaine 0.5%, 9 mg (1.8 mL) was injected intrathecally. Maternal blood samples were taken immediately after positioning the patient on the operating table (T1), before clamping the umbilical cord (T2) and 24 hours after the first sample was obtained (T3). Cord blood samples were drawn from the umbilical artery (T4). RESULTS: Maternal BDNF levels (pg mL-1) measured at T2 time point were higher in the general anaesthesia group compared to the spinal anaesthesia group (p<0.001). Cord blood BDNF levels were higher in the general anaesthesia group compared to the spinal anaesthesia group (p<0.001). In both groups, cord blood BDNF levels were significantly lower compared to the maternal blood samples collected at any time point (p<0.001, for all). There was a negative association between both maternal and cord blood BDNF levels with maternal MDA and cord blood MDA levels, respectively (r=-0.379, p<0.001; r=-0.375, p=0.001, respectively). CONCLUSION: The anaesthetic technique may have an influence on maternal peripheral and cord blood BDNF levels.
OBJECTIVE: Brain-derived neurotrophic factor (BDNF), a member of neurotrophins, plays a critical role in neuronal tissue. In this study, the effects of spinal or general anaesthesia on cord and maternal peripheral blood BDNF and malondialdehyde (MDA) levels were investigated in patients undergoing elective caesarean section. METHODS: Eighty patients with term pregnancy were included. General anaesthesia was induced with intravenous (IV) propofol 2 mg kg-1 in the general anaesthesia group (n=36). In the spinal anaesthesia group (n=35), hyperbaric bupivacaine 0.5%, 9 mg (1.8 mL) was injected intrathecally. Maternal blood samples were taken immediately after positioning the patient on the operating table (T1), before clamping the umbilical cord (T2) and 24 hours after the first sample was obtained (T3). Cord blood samples were drawn from the umbilical artery (T4). RESULTS: Maternal BDNF levels (pg mL-1) measured at T2 time point were higher in the general anaesthesia group compared to the spinal anaesthesia group (p<0.001). Cord blood BDNF levels were higher in the general anaesthesia group compared to the spinal anaesthesia group (p<0.001). In both groups, cord blood BDNF levels were significantly lower compared to the maternal blood samples collected at any time point (p<0.001, for all). There was a negative association between both maternal and cord blood BDNF levels with maternal MDA and cord blood MDA levels, respectively (r=-0.379, p<0.001; r=-0.375, p=0.001, respectively). CONCLUSION: The anaesthetic technique may have an influence on maternal peripheral and cord blood BDNF levels.
Authors: H Kulacoglu; M Ozdogan; A Gurer; Eren P Ersoy; A Onder Devay; S Duygulu Devay; O Gulbahar; S Gogkus Journal: Bratisl Lek Listy Date: 2007 Impact factor: 1.278
Authors: D L A Van den Hove; H W M Steinbusch; A Scheepens; W D J Van de Berg; L A M Kooiman; B J G Boosten; J Prickaerts; C E Blanco Journal: Neuroscience Date: 2005-10-20 Impact factor: 3.590