Literature DB >> 29742324

Effective Assignment of α2,3/α2,6-Sialic Acid Isomers by LC-MS/MS-Based Glycoproteomics.

Christian Pett1,2, Waqas Nasir3,4, Carina Sihlbom5, Britt-Marie Olsson5, Vanessa Caixeta1, Manuel Schorlemer1,2, René P Zahedi1,6, Göran Larson3, Jonas Nilsson3, Ulrika Westerlind1,2.   

Abstract

Distinct structural changes of the α2,3/α2,6-sialic acid glycosidic linkages on glycoproteins are of importance in cancer biology, inflammatory diseases, and virus tropism. Current glycoproteomic methodologies are, however, not amenable toward high-throughput characterization of sialic acid isomers. To enable such assignments, a mass spectrometry method utilizing synthetic model glycopeptides for the analysis of oxonium ion intensity ratios was developed. This method was successfully applied in large-scale glycoproteomics, thus allowing the site-specific structural characterization of sialic acid isomers.
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  glycopeptides; glycosylation; isomers; mass spectrometry; sialic acids

Mesh：

Substances：

Year:  2018        PMID： 29742324     DOI： 10.1002/anie.201803540

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  10 in total

1.  Identifying Sialylation Linkages at the Glycopeptide Level by Glycosyltransferase Labeling Assisted Mass Spectrometry (GLAMS).

Authors:  He Zhu; Shuaishuai Wang; Ding Liu; Lang Ding; Congcong Chen; Yunpeng Liu; Zhigang Wu; Roni Bollag; Kebin Liu; William Max Alexander; Jun Yin; Cheng Ma; Lei Li; Peng George Wang
Journal:  Anal Chem       Date:  2020-04-15       Impact factor: 6.986

2.  The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins.

Authors:  Stacy A Malaker; Kayvon Pedram; Michael J Ferracane; Barbara A Bensing; Venkatesh Krishnan; Christian Pett; Jin Yu; Elliot C Woods; Jessica R Kramer; Ulrika Westerlind; Oliver Dorigo; Carolyn R Bertozzi
Journal:  Proc Natl Acad Sci U S A       Date:  2019-03-25       Impact factor: 11.205

3.  Native Ion Mobility-Mass Spectrometry-Enabled Fast Structural Interrogation of Labile Protein Surface Modifications at the Intact Protein Level.

Authors:  Gongyu Li; Ashley Phetsanthad; Min Ma; Qinying Yu; Ashita Nair; Zhen Zheng; Fengfei Ma; Kellen DeLaney; Seungpyo Hong; Lingjun Li
Journal:  Anal Chem       Date:  2022-01-20       Impact factor: 6.986

Review 4.  Advancing Solutions to the Carbohydrate Sequencing Challenge.

Authors:  Christopher J Gray; Lukasz G Migas; Perdita E Barran; Kevin Pagel; Peter H Seeberger; Claire E Eyers; Geert-Jan Boons; Nicola L B Pohl; Isabelle Compagnon; Göran Widmalm; Sabine L Flitsch
Journal:  J Am Chem Soc       Date:  2019-08-21       Impact factor: 16.383

5.  Synthetic standard aided quantification and structural characterization of amyloid-beta glycopeptides enriched from cerebrospinal fluid of Alzheimer's disease patients.

Authors:  Jonas Nilsson; Gunnar Brinkmalm; Sherif Ramadan; Lisa Gilborne; Fredrik Noborn; Kaj Blennow; Anders Wallin; Johan Svensson; Mohamed A Abo-Riya; Xuefei Huang; Göran Larson
Journal:  Sci Rep       Date:  2019-04-02       Impact factor: 4.379

6.  Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.

Authors:  Nicholas M Riley; Alexander S Hebert; Michael S Westphall; Joshua J Coon
Journal:  Nat Commun       Date:  2019-03-21       Impact factor: 14.919

7.  Optimal Dissociation Methods Differ for N- and O-Glycopeptides.

Authors:  Nicholas M Riley; Stacy A Malaker; Marc D Driessen; Carolyn R Bertozzi
Journal:  J Proteome Res       Date:  2020-06-28       Impact factor: 4.466

Review 8.  Towards structure-focused glycoproteomics.

Authors:  Anastasia Chernykh; Rebeca Kawahara; Morten Thaysen-Andersen
Journal:  Biochem Soc Trans       Date:  2021-02-26       Impact factor: 5.407

9.  Glycoproteomic and Phenotypic Elucidation of B4GALNT2 Expression Variants in the SID Histo-Blood Group System.

Authors:  Linn Stenfelt; Jonas Nilsson; Åsa Hellberg; Yew Wah Liew; Jenny Morrison; Göran Larson; Martin L Olsson
Journal:  Int J Mol Sci       Date:  2022-04-01       Impact factor: 5.923

10.  Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics.

Authors:  Shuaishuai Wang; Congcong Chen; Madhusudhan Reddy Gadi; Varma Saikam; Ding Liu; He Zhu; Roni Bollag; Kebin Liu; Xi Chen; Fengshan Wang; Peng George Wang; Peixue Ling; Wanyi Guan; Lei Li
Journal:  Nat Commun       Date:  2021-06-11       Impact factor: 14.919
  10 in total

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