OBJECTIVES: To assess the feasibility of conducting a large clinical trial to evaluate the effectiveness of probiotics to reduce influenza and other respiratory virus infections in residents of long-term and chronic care facilities (LTCFs). DESIGN: Randomized, double-blind, placebo-controlled pilot trial. SETTING:Fourteen nursing homes in Hamilton and surrounding region, Ontario, Canada. PARTICIPANTS: Nursing home residents aged 65 and older (N=209). Those who were taking immunosuppressives (steroids or other immunosuppressives) or had a hematological malignancy, structural heart disease, or gastroesophageal or intestinal injury and others at high risk of an endovascular infection were excluded. INTERVENTION: Participants were randomized to receive study probiotics-2 capsules of Lactobacillus rhamnosus GG (estimated 10 billion colony forming units of L. rhamnosus GG per capsule) or placebo (calcium carbonate) daily for 6 months. MEASUREMENTS: Laboratory-confirmed respiratory viral infections. RESULTS:One hundred ninety-six individuals were included in the analysis: 100 in the probiotics group and 96 in the placebo group. Laboratory-confirmed respiratory viral infections were observed in 14 (15.0%) residents in the probiotic group and 21 (22.9%) in the placebo group (hazard ratio=0.65, 95% confidence interval=0.32-1.31). CONCLUSION: A larger trial is warranted to determine whether probiotics reduce influenza and other respiratory virus infections in residents of LTCFs.
RCT Entities:
OBJECTIVES: To assess the feasibility of conducting a large clinical trial to evaluate the effectiveness of probiotics to reduce influenza and other respiratory virus infections in residents of long-term and chronic care facilities (LTCFs). DESIGN: Randomized, double-blind, placebo-controlled pilot trial. SETTING: Fourteen nursing homes in Hamilton and surrounding region, Ontario, Canada. PARTICIPANTS: Nursing home residents aged 65 and older (N=209). Those who were taking immunosuppressives (steroids or other immunosuppressives) or had a hematological malignancy, structural heart disease, or gastroesophageal or intestinal injury and others at high risk of an endovascular infection were excluded. INTERVENTION: Participants were randomized to receive study probiotics-2 capsules of Lactobacillus rhamnosus GG (estimated 10 billion colony forming units of L. rhamnosus GG per capsule) or placebo (calcium carbonate) daily for 6 months. MEASUREMENTS: Laboratory-confirmed respiratory viral infections. RESULTS: One hundred ninety-six individuals were included in the analysis: 100 in the probiotics group and 96 in the placebo group. Laboratory-confirmed respiratory viral infections were observed in 14 (15.0%) residents in the probiotic group and 21 (22.9%) in the placebo group (hazard ratio=0.65, 95% confidence interval=0.32-1.31). CONCLUSION: A larger trial is warranted to determine whether probiotics reduce influenza and other respiratory virus infections in residents of LTCFs.
Authors: Christopher C Butler; Mandy Lau; David Gillespie; Eleri Owen-Jones; Mark Lown; Mandy Wootton; Philip C Calder; Antony J Bayer; Michael Moore; Paul Little; Jane Davies; Alison Edwards; Victoria Shepherd; Kerenza Hood; F D Richard Hobbs; Mina Davoudianfar; Heather Rutter; Helen Stanton; Rachel Lowe; Richard Fuller; Nick A Francis Journal: JAMA Date: 2020-07-07 Impact factor: 56.272
Authors: Hai Yun Shi; Xi Zhu; Wei Lin Li; Joyce W Y Mak; Sunny H Wong; Sheng Tao Zhu; Shui Long Guo; Francis K L Chan; Shu Tian Zhang; Siew C Ng Journal: Eur J Nutr Date: 2021-04-14 Impact factor: 4.865
Authors: Carolina F F A Costa; Benedita Sampaio-Maia; Ricardo Araujo; Diana S Nascimento; Joana Ferreira-Gomes; Manuel Pestana; Maria J Azevedo; Ines S Alencastre Journal: Nutrients Date: 2022-01-14 Impact factor: 5.717