Xiaochuan Wang1, Yi Zhang1, Liangqi Sun1, Shuaiping Wang1, Jing Nie1, Wenqing Zhao2, Guobao Zheng3. 1. Department of Clinical Laboratory, No. 150 Central Hospital of PLA, Luoyang, China. 2. Luoyang First Hospital of Traditional Chinese Medicine, Luoyang, China. 3. Department of Oncology, No. 150 Central Hospital of PLA, Luoyang, China.
Abstract
BACKGROUND: The early diagnostic of lung cancer plays an important role in the prognosis of surgical treatment among lung cancer patients. To evaluate the clinical application of multi-tumor markers protein biochip in the diagnosis of lung cancer, 12 tumor markers were detected in patients with different stages of lung cancer. METHODS: Serum CA125, CA19-9, Ferritin, CA15-3, CA242, CEA, AFP, NSE, PSA, f-PSA, HGH, and β-HGH were assessed in 506 patients, with 224 patients with lung cancer (including 123 cases of adenocarcinoma, 30 squamous cell carcinoma, 54 small-cell carcinoma, and 17 non classification), 159 patients with benign lung disease and 90 healthy people control by the C-12 multiple tumor protein-chip detective system. RESULTS: The positive rate of C-12 (77.23%) in lung cancer was significantly higher than that of benign lung disease (13.84%) and healthy people (9.76%) (P < .01). In lung cancer, the positive rate of CA199, NSE, CEA, CA242, Ferritin, f-PSA, and CA125 were significantly higher than that of benign lung disease and healthy people. In adenocarcinoma, the positive rate of CA125 (73.53%) was significantly higher than that of squamous cell carcinoma (36.67%) and small-cell carcinoma (56.62%). CONCLUSION: The C-12 multiple tumor protein-chip detective system has acceptable sensitivity in the diagnostic of lung cancer.
BACKGROUND: The early diagnostic of lung cancer plays an important role in the prognosis of surgical treatment among lung cancerpatients. To evaluate the clinical application of multi-tumor markers protein biochip in the diagnosis of lung cancer, 12 tumor markers were detected in patients with different stages of lung cancer. METHODS: Serum CA125, CA19-9, Ferritin, CA15-3, CA242, CEA, AFP, NSE, PSA, f-PSA, HGH, and β-HGH were assessed in 506 patients, with 224 patients with lung cancer (including 123 cases of adenocarcinoma, 30 squamous cell carcinoma, 54 small-cell carcinoma, and 17 non classification), 159 patients with benign lung disease and 90 healthy people control by the C-12 multiple tumor protein-chip detective system. RESULTS: The positive rate of C-12 (77.23%) in lung cancer was significantly higher than that of benign lung disease (13.84%) and healthy people (9.76%) (P < .01). In lung cancer, the positive rate of CA199, NSE, CEA, CA242, Ferritin, f-PSA, and CA125 were significantly higher than that of benign lung disease and healthy people. In adenocarcinoma, the positive rate of CA125 (73.53%) was significantly higher than that of squamous cell carcinoma (36.67%) and small-cell carcinoma (56.62%). CONCLUSION: The C-12 multiple tumor protein-chip detective system has acceptable sensitivity in the diagnostic of lung cancer.
Authors: P Foa; M Fornier; R Miceli; E Seregni; L Santambrogio; M Nosotti; I Cataldo; M Sala; S Caldiera; E Bombardieri Journal: Anticancer Res Date: 1999 Jul-Aug Impact factor: 2.480
Authors: Lindsey A Torre; Freddie Bray; Rebecca L Siegel; Jacques Ferlay; Joannie Lortet-Tieulent; Ahmedin Jemal Journal: CA Cancer J Clin Date: 2015-02-04 Impact factor: 508.702
Authors: M Díez; A Torres; M L Maestro; M D Ortega; A Gómez; M Pollán; J A Lopez; A Picardo; F Hernando; J L Balibrea Journal: Br J Cancer Date: 1996-05 Impact factor: 7.640