İbrahim Ozan Tekeli1, Ahmet Ateşşahin2, Fatih Sakin3, Abdullah Aslan4, Songül Çeribaşı5, Mustafa Yipel6. 1. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Mustafa Kemal University, 31060, Hatay, Turkey. ozantekeli@hotmail.com. 2. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Fırat University, 23119, Elazığ, Turkey. 3. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Mustafa Kemal University, 31060, Hatay, Turkey. 4. Department of Biology, Faculty of Science, Fırat University, 23119, Elazığ, Turkey. 5. Department of Pathology, Faculty of Veterinary Medicine, Fırat University, 23119, Elazığ, Turkey. 6. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Namık Kemal University, 59030, Tekirdağ, Turkey.
Abstract
OBJECTIVE: To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. METHODS: Conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) were administered in vivo orally for 7 days and sulfasalazine (100 mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochemical and histopathological analysis. RESULTS: Malondialdehyde (MDA), interleukin 1β (IL-1β), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) levels were decreased (p < 0.05) in the targeted groups compared to the AA group, whereas nuclear factor-erythroid 2-related factor 2 (Nrf-2) level was increased (p < 0.05). Tumor necrosis factor α (TNF-α) level was also decreased (p < 0.05) and catalase activity (CAT) was increased (p < 0.05) in the TLC group compared to the AA group. IL-1β and IL-6 levels were lower in the TLC group compared to the conventional LC and sulfasalazine groups (p < 0.05). COX-2 and NF-κB levels were lower, while the Nrf-2 level was higher in the targeted groups compared to the conventional groups (p < 0.05). Furthermore, COX-2 level was lower and Nrf-2 level was higher in the targeted groups compared to the sulfasalazine group (p < 0.05). CONCLUSION: As expected, sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC, which deserves to be investigated further.
OBJECTIVE: To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. METHODS: Conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) were administered in vivo orally for 7 days and sulfasalazine (100 mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochemical and histopathological analysis. RESULTS:Malondialdehyde (MDA), interleukin 1β (IL-1β), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) levels were decreased (p < 0.05) in the targeted groups compared to the AA group, whereas nuclear factor-erythroid 2-related factor 2 (Nrf-2) level was increased (p < 0.05). Tumor necrosis factor α (TNF-α) level was also decreased (p < 0.05) and catalase activity (CAT) was increased (p < 0.05) in the TLC group compared to the AA group. IL-1β and IL-6 levels were lower in the TLC group compared to the conventional LC and sulfasalazine groups (p < 0.05). COX-2 and NF-κB levels were lower, while the Nrf-2 level was higher in the targeted groups compared to the conventional groups (p < 0.05). Furthermore, COX-2 level was lower and Nrf-2 level was higher in the targeted groups compared to the sulfasalazine group (p < 0.05). CONCLUSION: As expected, sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC, which deserves to be investigated further.
Authors: Abdullah Aslan; Yousif Taha Hussein; Ozlem Gok; Seda Beyaz; Orhan Erman; Serpil Baspinar Journal: Environ Sci Pollut Res Int Date: 2019-12-29 Impact factor: 4.223
Authors: Maryam Ghasemi-Dehnoo; Amir Abbas Safari; Mohammad Rahimi-Madiseh; Zahra Lorigooini; Mohammad Taghi Moradi; Hossein Amini-Khoei Journal: Evid Based Complement Alternat Med Date: 2022-04-06 Impact factor: 2.629
Authors: Abdullah Aslan; Muhammed Ismail Can; Ozlem Gok; Seda Beyaz; Gozde Parlak; Ibrahim Hanifi Ozercan Journal: Environ Sci Pollut Res Int Date: 2021-09-15 Impact factor: 4.223