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Literature DB >> 29736304

The contrasting roles of inflammasomes in cancer.

Abstract

Chronic inflammation plays a decisive role at different stages of cancer development. Inflammasomes are oligomeric protein complexes activated in response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). PAMPs and DAMPs are released from infected cells, tumors and damaged tissues. Inflammasomes activate and release inflammatory cytokines such as IL-1β and IL-18. The various inflammasomes and inflammatory cytokines and chemokines play contrasting roles in cancer development and progression. In this review, we describe the roles of different inflammasomes in lung, breast, gastric, liver, colon, and prostate cancers and in glioblastomas.

Entities: Disease Gene

Keywords: Inflammasomes; cancer; immune system; tumor microenvironment

Year: 2018 PMID： 29736304 PMCID： PMC5934549

Source DB: PubMed Journal: Am J Cancer Res ISSN： 2156-6976 Impact factor: 6.166

176 in total

1. IL-1β-mediated repression of microRNA-101 is crucial for inflammation-promoted lung tumorigenesis.

Authors: Lin Wang; Ling-Fei Zhang; Jing Wu; Shu-Jun Xu; Yang-Yang Xu; Dangsheng Li; Jia-Tao Lou; Mo-Fang Liu
Journal: Cancer Res Date: 2014-06-23 Impact factor: 12.701

2. Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition.

Authors: Michail Mamantopoulos; Francesca Ronchi; Filip Van Hauwermeiren; Sara Vieira-Silva; Bahtiyar Yilmaz; Liesbet Martens; Yvan Saeys; Stefan K Drexler; Amir S Yazdi; Jeroen Raes; Mohamed Lamkanfi; Kathy D McCoy; Andy Wullaert
Journal: Immunity Date: 2017-08-08 Impact factor: 31.745

3. [Effect of interleukin-18 gene modified human umbilical cord mesenchymal stem cells on proliferation of breast cancer cell].

Authors: Suyuan Sun; Xiaoyi Liu; Dandan Jiang; Zhidong Lü; Funian Li
Journal: Zhonghua Yi Xue Za Zhi Date: 2014-07-08

4. Complement activation promotes colitis-associated carcinogenesis through activating intestinal IL-1β/IL-17A axis.

Authors: C Ning; Y-Y Li; Y Wang; G-C Han; R-X Wang; H Xiao; X-Y Li; C-M Hou; Y-F Ma; D-S Sheng; B-F Shen; J-N Feng; R-F Guo; Y Li; G-J Chen
Journal: Mucosal Immunol Date: 2015-03-04 Impact factor: 7.313

Review 5. Neutralizing tumor-promoting chronic inflammation: a magic bullet?

Authors: Lisa M Coussens; Laurence Zitvogel; A Karolina Palucka
Journal: Science Date: 2013-01-18 Impact factor: 47.728

6. Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis.

Authors: Y Wang; K Wang; G-C Han; R-X Wang; H Xiao; C-M Hou; R-F Guo; Y Dou; B-F Shen; Y Li; G-J Chen
Journal: Mucosal Immunol Date: 2014-01-15 Impact factor: 7.313

7. Methylation of ASC/TMS1 promoter is associated with poor prognosis of patients with gastric cancer.

Authors: L Wu; C Zhang; X Wang; X Ding; J Deng; H Liang
Journal: Clin Transl Oncol Date: 2015-08-11 Impact factor: 3.405

8. Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression.

Authors: Qing Wei; Kun Mu; Tao Li; Ying Zhang; Zhaowen Yang; Xiaoqing Jia; Wei Zhao; Wanwan Huai; Pengbo Guo; Lihui Han
Journal: Lab Invest Date: 2013-10-28 Impact factor: 5.662

9. Adenoviral-mediated interleukin-18 expression in mesenchymal stem cells effectively suppresses the growth of glioma in rats.

Authors: Gang Xu; Xiao-Dan Jiang; Ying Xu; Jing Zhang; Fan-Heng Huang; Zhen-Zhou Chen; De-Xiang Zhou; Jiang-Hua Shang; Yu-Xi Zou; Ying-Qian Cai; Sheng-Bin Kou; Yi-Zhao Chen; Ru-Xiang Xu; Yan-Jun Zeng
Journal: Cell Biol Int Date: 2008-08-06 Impact factor: 3.612

10. S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β.

Authors: Benjamin Weichand; Rüdiger Popp; Sarah Dziumbla; Javier Mora; Elisabeth Strack; Eiman Elwakeel; Ann-Christin Frank; Klaus Scholich; Sandra Pierre; Shahzad N Syed; Catherine Olesch; Julia Ringleb; Bilge Ören; Claudia Döring; Rajkumar Savai; Michaela Jung; Andreas von Knethen; Bodo Levkau; Ingrid Fleming; Andreas Weigert; Bernhard Brüne
Journal: J Exp Med Date: 2017-07-24 Impact factor: 14.307

25 in total

1. The platelet NLRP3 inflammasome is upregulated in a murine model of pancreatic cancer and promotes platelet aggregation and tumor growth.

Authors: Brian A Boone; Pranav Murthy; Jennifer L Miller-Ocuin; Xiaoyan Liang; Kira L Russell; Patricia Loughran; Meinrad Gawaz; Michael T Lotze; Herbert J Zeh; Sebastian Vogel
Journal: Ann Hematol Date: 2019-04-24 Impact factor: 3.673

2. Mitochondrial Oxidative Phosphorylation Complex Regulates NLRP3 Inflammasome Activation and Predicts Patient Survival in Nasopharyngeal Carcinoma.

Authors: I-Che Chung; Lih-Chyang Chen; Ngan-Ming Tsang; Wen-Yu Chuang; Tzu-Chieh Liao; Sheng-Ning Yuan; Chun-Nan OuYang; David M Ojcius; Chih-Ching Wu; Yu-Sun Chang
Journal: Mol Cell Proteomics Date: 2019-11-13 Impact factor: 5.911

Review 3. Tumor-Associated Inflammation: The Tumor-Promoting Immunity in the Early Stages of Tumorigenesis.

Authors: Qing Bi; Ji-Yue Wu; Xue-Meng Qiu; Jian-Dong Zhang; Ze-Jia Sun; Wei Wang
Journal: J Immunol Res Date: 2022-06-13 Impact factor: 4.493

4. Promoter methylation status of ASC/TMS1/PYCARD is associated with decreased overall survival and TNM status in patients with early stage non-small cell lung cancer (NSCLC).

Authors: Maja Šutić; Antje Motzek; Gordana Bubanović; Matthias Linke; Ivan Sabol; Oliver Vugrek; Petar Ozretić; Luka Brčić; Sven Seiwerth; Željko Debeljak; Antonija Jakovčević; Zoran Janevski; Dinko Stančić-Rokotov; Andrea Vukić-Dugac; Marko Jakopović; Miroslav Samaržija; Ulrich Zechner; Jelena Knežević
Journal: Transl Lung Cancer Res Date: 2019-12

Review 5. Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update.

Authors: Gulsum Ozlem Elpek
Journal: World J Clin Cases Date: 2021-07-06 Impact factor: 1.337

6. Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer.

Authors: Yang Hu; Baraa K Manasrah; Stephanie M McGregor; Robert F Lera; Roshan X Norman; John B Tucker; Christina M Scribano; Rachel E Yan; Mouhita Humayun; Kari B Wisinski; Amye J Tevaarwerk; Ruth M O'Regan; Lee G Wilke; Beth A Weaver; David J Beebe; Ning Jin; Mark E Burkard
Journal: Mol Cancer Ther Date: 2021-09-28 Impact factor: 6.261