Victoria J Bray1, Haryana M Dhillon2, Janette L Vardy3,4. 1. Department of Medical Oncology, Liverpool Hospital, Liverpool, NSW, 2170, Australia. 2. Centre for Medical Psychology & Evidence-based Decision-making, University of Sydney, Level 6, The Chris O'Brien Lifehouse, Sydney, NSW, 2006, Australia. 3. Department of Medical Oncology, Concord Cancer Centre, Concord Repatriation General Hospital, Concord, NSW, 2139, Australia. janette.vardy@sydney.edu.au. 4. Sydney Medical School, University of Sydney, Sydney, NSW, 2006, Australia. janette.vardy@sydney.edu.au.
Abstract
PURPOSE: Cognitive symptoms are common in cancer patients, with up to 70% reporting cognitive symptoms following chemotherapy. These symptoms can have a major impact on how an individual functions in all aspects of their lives. This review evaluates self-reported cognitive function and its associations with neuropsychological tests and patient-reported outcomes in adult cancer patients who received chemotherapy treatment for a solid cancer. METHODS: A search of multiple databases (Medline, Ovid at Nursing, PsycINFO, Allied and Complementary Medicine) from 1936 to 2017 was conducted, identifying 1563 unique articles, of which 101 met inclusion criteria. RESULTS: Of the 101 included studies, 48 (47%) were cross-sectional and 38 (38%) longitudinal in design, with 12 (12%) randomised controlled trials. A minority (26%) incorporated a healthy control arm in the study design, whilst the majority (79%) were in women with breast cancer. There was diversity in the assessment of self-reported cognitive symptoms. A total of 43 of 44 studies that sought an association between self-reported cognitive function and patient-reported outcomes found a moderate to strong association. Overall, 31 studies showed a lack of association between self-reported cognitive symptoms and neuropsychological results, whilst 14 studies reported a significant association between the two, but the association was often restricted to limited cognitive domains. CONCLUSION: The review found widespread heterogeneity in the assessment of self-reported cognitive symptoms and consistently absent or weak association with neuropsychological test scores. IMPLICATIONS FOR CANCER SURVIVORS: This research highlights the need for a standardised approach to measurement of self-reported cognitive symptoms in cancer patients.
PURPOSE:Cognitive symptoms are common in cancerpatients, with up to 70% reporting cognitive symptoms following chemotherapy. These symptoms can have a major impact on how an individual functions in all aspects of their lives. This review evaluates self-reported cognitive function and its associations with neuropsychological tests and patient-reported outcomes in adult cancerpatients who received chemotherapy treatment for a solid cancer. METHODS: A search of multiple databases (Medline, Ovid at Nursing, PsycINFO, Allied and Complementary Medicine) from 1936 to 2017 was conducted, identifying 1563 unique articles, of which 101 met inclusion criteria. RESULTS: Of the 101 included studies, 48 (47%) were cross-sectional and 38 (38%) longitudinal in design, with 12 (12%) randomised controlled trials. A minority (26%) incorporated a healthy control arm in the study design, whilst the majority (79%) were in women with breast cancer. There was diversity in the assessment of self-reported cognitive symptoms. A total of 43 of 44 studies that sought an association between self-reported cognitive function and patient-reported outcomes found a moderate to strong association. Overall, 31 studies showed a lack of association between self-reported cognitive symptoms and neuropsychological results, whilst 14 studies reported a significant association between the two, but the association was often restricted to limited cognitive domains. CONCLUSION: The review found widespread heterogeneity in the assessment of self-reported cognitive symptoms and consistently absent or weak association with neuropsychological test scores. IMPLICATIONS FOR CANCER SURVIVORS: This research highlights the need for a standardised approach to measurement of self-reported cognitive symptoms in cancerpatients.
Entities:
Keywords:
Cancer; Chemotherapy; Cognition; Cognitive symptoms; Self-reported cognitive function
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