Lindsay C Kobayashi1, Harvey Jay Cohen2, Wanting Zhai3, Xingtao Zhou3, Brent J Small4,5, George Luta6, Arti Hurria7, Judith Carroll8, Danielle Tometich9, Brenna C McDonald10, Deena Graham11, Heather S L Jim5, Paul Jacobsen12, James C Root13, Andrew J Saykin10, Tim A Ahles13, Jeanne Mandelblatt3. 1. Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA. 2. Center for the Study of Aging and Human Development, Duke University, Durham, North Carolina, USA. 3. Department of Oncology and Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. 4. School of Aging Studies, University of South Florida, Tampa, Florida, USA. 5. Moffitt Cancer Center, University of South Florida, Tampa, Florida, USA. 6. Department of Biostatistics, Bioinformatics, and Biomathematics and Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. 7. Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA. 8. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, California, USA. 9. Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA. 10. Center for Neuroimaging, Department of Radiology and Imaging Sciences and the Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA. 11. Hackensack University Medical Center, Hackensack, New Jersey, USA. 12. Healthcare Delivery Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Shady, Maryland, USA. 13. Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Abstract
OBJECTIVE: To investigate the relationships between self-reported and objectively measured cognitive function prior to systemic therapy and subsequent well-being outcomes over 24 months in older breast cancer survivors. METHODS: Data were from 397 women aged 60 to 98 diagnosed with non-metastatic breast cancer in the Thinking and Living with Cancer Study recruited from 2010-2016. Cognitive function was measured at baseline (following surgery, prior to systemic therapy) using neuropsychological assessments of attention, processing speed, and executive function (APE), learning and memory (LM), and the self-reported FACT-Cog scale. Well-being was measured using the FACT-G functional, physical, social, and emotional well-being domain scales at baseline and 12 and 24 months later, scaled from 0 (low) to 100 (high). Linear mixed-effects models assessed the relationships between each of baseline APE, LM, and FACT-Cog quartiles with well-being scores over 24 months, adjusted for confounding variables. RESULTS: At baseline, older survivors in the lowest APE, LM, and FACT-Cog score quartiles experienced poorer global well-being than those in the highest quartiles. At 24 months, older survivors tended to improve in well-being, and there were no differences according to baseline APE or LM scores. At 24 months, mean global well-being was 80.3 (95% CI: 76.2-84.3) among those in the lowest vs 86.6 (95% CI: 83.1-90.1) in the highest FACT-cog quartile, a clinically meaningful difference of 6.3 points (95% CI: 1.5-11.1). CONCLUSIONS: Among older breast cancer survivors, self-reported, but not objective cognitive impairments, were associated with lower global well-being over the first 2 years of survivorship.
OBJECTIVE: To investigate the relationships between self-reported and objectively measured cognitive function prior to systemic therapy and subsequent well-being outcomes over 24 months in older breast cancer survivors. METHODS: Data were from 397 women aged 60 to 98 diagnosed with non-metastatic breast cancer in the Thinking and Living with Cancer Study recruited from 2010-2016. Cognitive function was measured at baseline (following surgery, prior to systemic therapy) using neuropsychological assessments of attention, processing speed, and executive function (APE), learning and memory (LM), and the self-reported FACT-Cog scale. Well-being was measured using the FACT-G functional, physical, social, and emotional well-being domain scales at baseline and 12 and 24 months later, scaled from 0 (low) to 100 (high). Linear mixed-effects models assessed the relationships between each of baseline APE, LM, and FACT-Cog quartiles with well-being scores over 24 months, adjusted for confounding variables. RESULTS: At baseline, older survivors in the lowest APE, LM, and FACT-Cog score quartiles experienced poorer global well-being than those in the highest quartiles. At 24 months, older survivors tended to improve in well-being, and there were no differences according to baseline APE or LM scores. At 24 months, mean global well-being was 80.3 (95% CI: 76.2-84.3) among those in the lowest vs 86.6 (95% CI: 83.1-90.1) in the highest FACT-cog quartile, a clinically meaningful difference of 6.3 points (95% CI: 1.5-11.1). CONCLUSIONS: Among older breast cancer survivors, self-reported, but not objective cognitive impairments, were associated with lower global well-being over the first 2 years of survivorship.
Authors: Kathleen Van Dyk; Aimee M Hunter; Linda Ercoli; Laura Petersen; Andrew F Leuchter; Patricia A Ganz Journal: Breast Cancer Res Treat Date: 2017-07-13 Impact factor: 4.872
Authors: Arti Hurria; Enrique Soto-Perez-de-Celis; Jacob B Allred; Harvey Jay Cohen; Anait Arsenyan; Karla Ballman; Jennifer Le-Rademacher; Aminah Jatoi; Julie Filo; Jeanne Mandelblatt; Jacqueline M Lafky; Gretchen Kimmick; Heidi D Klepin; Rachel A Freedman; Harold Burstein; Julie Gralow; Antonio C Wolff; Gustav Magrinat; Myra Barginear; Hyman Muss Journal: J Am Geriatr Soc Date: 2018-08-26 Impact factor: 5.562
Authors: Allison Magnuson; Heather Allore; Harvey Jay Cohen; Supriya G Mohile; Grant R Williams; Andrew Chapman; Martine Extermann; Rebecca L Olin; Valerie Targia; Amy Mackenzie; Holly M Holmes; Arti Hurria Journal: J Geriatr Oncol Date: 2016-07-05 Impact factor: 3.599
Authors: Kimberly D Miller; Rebecca L Siegel; Chun Chieh Lin; Angela B Mariotto; Joan L Kramer; Julia H Rowland; Kevin D Stein; Rick Alteri; Ahmedin Jemal Journal: CA Cancer J Clin Date: 2016-06-02 Impact factor: 508.702
Authors: Brent J Small; Marie Lange; Jeanne Mandelblatt; Florence Joly; Wanting Zhai; Jaeil Ahn; Tim A Ahles; Judith E Carroll; Harvey J Cohen; Deena Graham; Martine Extermann; Natacha Heutte; Heather S L Jim; Brenna C McDonald; Sunita K Patel; James C Root; Andrew J Saykin; Kathleen Van Dyk; Xingtao Zhou Journal: Breast Cancer Res Treat Date: 2021-11-24 Impact factor: 4.872
Authors: Jeanne S Mandelblatt; Tim A Ahles; James C Root; Xingtao Zhou; Jaeil Ahn; Brent J Small; Wanting Zhai; Traci Bethea; Judith E Carroll; Harvey Jay Cohen; Asma Dilawari; Martine Extermann; Deena Graham; Claudine Isaacs; Paul B Jacobsen; Heather Jim; Brenna C McDonald; Zev M Nakamura; Sunita K Patel; Kelly Rentscher; Andrew J Saykin; Kathleen Van Dyk Journal: Breast Cancer Res Treat Date: 2022-05-19 Impact factor: 4.624
Authors: Jeanne S Mandelblatt; Xingtao Zhou; Brent J Small; Jaeil Ahn; Wanting Zhai; Tim Ahles; Martine Extermann; Deena Graham; Paul B Jacobsen; Heather Jim; Brenna C McDonald; Sunita K Patel; James C Root; Andrew J Saykin; Harvey Jay Cohen; Judith E Carroll Journal: J Natl Cancer Inst Date: 2021-10-01 Impact factor: 13.506
Authors: Kathleen Van Dyk; Xingtao Zhou; Brent J Small; Jaeil Ahn; Wanting Zhai; Tim Ahles; Deena Graham; Paul B Jacobsen; Heather Jim; Brenna C McDonald; Kelly Nudelman Holohan; Sunita K Patel; G William Rebeck; James C Root; Andrew J Saykin; Harvey Jay Cohen; Jeanne S Mandelblatt; Judith E Carroll Journal: JNCI Cancer Spectr Date: 2021-01-27
Authors: Kelly E Rentscher; Xingtao Zhou; Brent J Small; Harvey J Cohen; Asma A Dilawari; Sunita K Patel; Traci N Bethea; Kathleen M Van Dyk; Zev M Nakamura; Jaeil Ahn; Wanting Zhai; Tim A Ahles; Heather S L Jim; Brenna C McDonald; Andrew J Saykin; James C Root; Deena M A Graham; Judith E Carroll; Jeanne S Mandelblatt Journal: Cancer Date: 2021-06-23 Impact factor: 6.860