Literature DB >> 29728950

High Rate of Discontinuation May Diminish PrEP Coverage Among Young Men Who Have Sex with Men.

Ethan Morgan1,2, Daniel T Ryan3,4, Michael E Newcomb3,4, Brian Mustanski3,4.   

Abstract

Understanding pre-exposure prophylaxis (PrEP) discontinuation is key to maximizing its effectiveness at the individual and population levels. Data came from the RADAR cohort study of MSM aged 16-29 years, 2015-2017. Participants included those who reported past 6-month PrEP use and discontinued its use by the interview date. Of the 197 participants who had used PrEP in the past 6 months, 65 discontinued use. Primary reasons for PrEP discontinuation included trouble getting to doctor's appointments (14, 21.5%) and issues related to insurance coverage or loss (13, 20.0%). Few (21%) who discontinued spoke to their doctor first, which has important implications for future long acting formulations.

Entities:  

Keywords:  Discontinuation; HIV; PrEP; YMSM

Mesh：

Substances：

Year:  2018        PMID： 29728950      PMCID： PMC6204096          DOI： 10.1007/s10461-018-2125-2

Source DB:  PubMed          Journal:  AIDS Behav        ISSN： 1090-7165


  7 in total

1.  Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.

Authors:  Robert M Grant; Javier R Lama; Peter L Anderson; Vanessa McMahan; Albert Y Liu; Lorena Vargas; Pedro Goicochea; Martín Casapía; Juan Vicente Guanira-Carranza; Maria E Ramirez-Cardich; Orlando Montoya-Herrera; Telmo Fernández; Valdilea G Veloso; Susan P Buchbinder; Suwat Chariyalertsak; Mauro Schechter; Linda-Gail Bekker; Kenneth H Mayer; Esper Georges Kallás; K Rivet Amico; Kathleen Mulligan; Lane R Bushman; Robert J Hance; Carmela Ganoza; Patricia Defechereux; Brian Postle; Furong Wang; J Jeff McConnell; Jia-Hua Zheng; Jeanny Lee; James F Rooney; Howard S Jaffe; Ana I Martinez; David N Burns; David V Glidden
Journal:  N Engl J Med       Date:  2010-11-23       Impact factor: 91.245

2.  Preexposure Prophylaxis for HIV Prevention in a Large Integrated Health Care System: Adherence, Renal Safety, and Discontinuation.

Authors:  Julia L Marcus; Leo B Hurley; Charles Bradley Hare; Dong Phuong Nguyen; Tony Phengrasamy; Michael J Silverberg; Juliet E Stoltey; Jonathan E Volk
Journal:  J Acquir Immune Defic Syndr       Date:  2016-12-15       Impact factor: 3.731

Review 3.  Tenofovir-based pre-exposure prophylaxis for HIV prevention: evolving evidence.

Authors:  Connie Celum; Jared M Baeten
Journal:  Curr Opin Infect Dis       Date:  2012-02       Impact factor: 4.915

4.  Accuracy of highly sexually active gay and bisexual men's predictions of their daily likelihood of anal sex and its relevance for intermittent event-driven HIV pre-exposure prophylaxis.

Authors:  Jeffrey T Parsons; H Jonathon Rendina; Christian Grov; Ana Ventuneac; Brian Mustanski
Journal:  J Acquir Immune Defic Syndr       Date:  2015-04-01       Impact factor: 3.731

5.  Effects of Parental Monitoring and Knowledge on Substance Use and HIV Risk Behaviors Among Young Men Who have Sex with Men: Results from Three Studies.

Authors:  Brian Mustanski; Gregory Swann; Michael E Newcomb; Nikhil Prachand
Journal:  AIDS Behav       Date:  2017-07

6.  Prevalence and correlates of smoking and e-cigarette use among young men who have sex with men and transgender women.

Authors:  Mary A Gerend; Michael E Newcomb; Brian Mustanski
Journal:  Drug Alcohol Depend       Date:  2017-08-16       Impact factor: 4.492

7.  High acceptability of HIV pre-exposure prophylaxis but challenges in adherence and use: qualitative insights from a phase I trial of intermittent and daily PrEP in at-risk populations in Kenya.

Authors:  Elisabeth Maria Van der Elst; Judie Mbogua; Don Operario; Gaudensia Mutua; Caroline Kuo; Peter Mugo; Jennifer Kanungi; Sagri Singh; Jessica Haberer; Frances Priddy; Eduard Joachim Sanders
Journal:  AIDS Behav       Date:  2013-07
  7 in total
  45 in total

1.  Pre-exposure Prophylaxis for HIV Infection: Preventing Disease or Promoting Sexual Health?

Authors:  Ronald O Valdiserri; David R Holtgrave
Journal:  J Community Health       Date:  2019-06

2.  Demographic, Behavioral, and Geographic Differences Between Men, Transmen, and Transwomen Currently on PrEP, Former PrEP Users, and Those Having Never Used PrEP.

Authors:  Drew A Westmoreland; David W Pantalone; Viraj V Patel; Donald Hoover; Denis Nash; Christian Grov
Journal:  AIDS Behav       Date:  2020-05

3.  Rectal Douching and Microbicide Acceptability among Young Men who Have Sex with Men.

Authors:  Ryan C Tingler; Daniel Connochie; José A Bauermeister
Journal:  AIDS Behav       Date:  2020-05

4.  Barriers and Facilitators of PrEP Adherence for Young Men and Transgender Women of Color.

Authors:  Sarah Wood; Robert Gross; Judy A Shea; José A Bauermeister; Joshua Franklin; Danielle Petsis; Meghan Swyryn; Linden Lalley-Chareczko; Helen C Koenig; Nadia Dowshen
Journal:  AIDS Behav       Date:  2019-10

5.  Insurance- and medical provider-related barriers and facilitators to staying on PrEP: results from a qualitative study.

Authors:  Alexa B D'Angelo; Javier Lopez-Rios; Anthony W P Flynn; Ian W Holloway; David W Pantalone; Christian Grov
Journal:  Transl Behav Med       Date:  2021-03-16       Impact factor: 3.046

Review 6.  Initiation, discontinuation, and restarting HIV pre-exposure prophylaxis: ongoing implementation strategies.

Authors:  Sarah E Rutstein; Dawn K Smith; Shona Dalal; Rachel C Baggaley; Myron S Cohen
Journal:  Lancet HIV       Date:  2020-08-27       Impact factor: 12.767

Review 7.  HIV Prevention Interventions for Adolescents.

Authors:  Sybil Hosek; Audrey Pettifor
Journal:  Curr HIV/AIDS Rep       Date:  2019-02       Impact factor: 5.071

8.  Individual and Partner Characteristics Associated With Intentions to Use PrEP Among Partnered Men, Trans Men, and Trans Women in Sero-Concordant and -Discordant Relationships in the United States.

Authors:  Drew A Westmoreland; Alexa D'Angelo; Denis Nash; Christian Grov
Journal:  AIDS Educ Prev       Date:  2020-10

Review 9.  Navigating the Long Road Forward for Maximizing PrEP Impact Among Adolescent Men Who Have Sex with Men.

Authors:  David M Huebner; Brian Mustanski
Journal:  Arch Sex Behav       Date:  2019-10-30

10.  Brief Report: Integration of PrEP Services Into Routine Antenatal and Postnatal Care: Experiences From an Implementation Program in Western Kenya.

Authors:  Jillian Pintye; John Kinuthia; D Allen Roberts; Anjuli D Wagner; Kenneth Mugwanya; Felix Abuna; Harison Lagat; George Owiti; Carol E Levin; Ruanne V Barnabas; Jared M Baeten; Grace John-Stewart
Journal:  J Acquir Immune Defic Syndr       Date:  2018-12-15       Impact factor: 3.731
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