Literature DB >> 29727689

A Comprehensive cis-eQTL Analysis Revealed Target Genes in Breast Cancer Susceptibility Loci Identified in Genome-wide Association Studies.

Xingyi Guo1, Weiqiang Lin2, Jiandong Bao3, Qiuyin Cai4, Xiao Pan2, Mengqiu Bai2, Yuan Yuan2, Jiajun Shi4, Yaqiong Sun4, Mi-Ryung Han4, Jing Wang5, Qi Liu5, Wanqing Wen4, Bingshan Li6, Jirong Long4, Jianghua Chen7, Wei Zheng4.   

Abstract

Genome-wide association studies (GWASs) have identified more than 150 common genetic loci for breast cancer risk. However, the target genes and underlying mechanisms remain largely unknown. We conducted a cis-expression quantitative trait loci (cis-eQTL) analysis using normal or tumor breast transcriptome data from the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), The Cancer Genome Atlas (TCGA), and the Genotype-Tissue Expression (GTEx) project. We identified a total of 101 genes for 51 lead variants after combing the results of a meta-analysis of METABRIC and TCGA, and the results from GTEx at a Benjamini-Hochberg (BH)-adjusted p < 0.05. Using luciferase reporter assays in both estrogen-receptor positive (ER+) and negative (ER-) cell lines, we showed that alternative alleles of potential functional single-nucleotide polymorphisms (SNPs), rs11552449 (DCLRE1B), rs7257932 (SSBP4), rs3747479 (MRPS30), rs2236007 (PAX9), and rs73134739 (ATG10), could significantly change promoter activities of their target genes compared to reference alleles. Furthermore, we performed in vitro assays in breast cancer cell lines, and our results indicated that DCLRE1B, MRPS30, and ATG10 played a vital role in breast tumorigenesis via certain disruption of cell behaviors. Our findings revealed potential target genes for associations of genetic susceptibility risk loci and provided underlying mechanisms for a better understanding of the pathogenesis of breast cancer.
Copyright © 2018 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  GWAS; bioinformatics; breast cancer; cell behavior; cis-eQTL; functional SNP; functional genomics; gene expression; risk variant; susceptibility gene

Mesh：

Substances：

Year:  2018        PMID： 29727689      PMCID： PMC5986971          DOI： 10.1016/j.ajhg.2018.03.016

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  59 in total

1.  Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.

Authors:  Bert Gold; Tomas Kirchhoff; Stefan Stefanov; James Lautenberger; Agnes Viale; Judy Garber; Eitan Friedman; Steven Narod; Adam B Olshen; Peter Gregersen; Kristi Kosarin; Adam Olsh; Julie Bergeron; Nathan A Ellis; Robert J Klein; Andrew G Clark; Larry Norton; Michael Dean; Jeff Boyd; Kenneth Offit
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-07       Impact factor: 11.205

2.  Quantifying uncertainty in genotype calls.

Authors:  Benilton S Carvalho; Thomas A Louis; Rafael A Irizarry
Journal:  Bioinformatics       Date:  2009-11-11       Impact factor: 6.937

3.  A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping.

Authors:  Suhas S P Rao; Miriam H Huntley; Neva C Durand; Elena K Stamenova; Ivan D Bochkov; James T Robinson; Adrian L Sanborn; Ido Machol; Arina D Omer; Eric S Lander; Erez Lieberman Aiden
Journal:  Cell       Date:  2014-12-11       Impact factor: 41.582

4.  A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.

Authors:  Afshan Siddiq; Fergus J Couch; Gary K Chen; Sara Lindström; Diana Eccles; Robert C Millikan; Kyriaki Michailidou; Daniel O Stram; Lars Beckmann; Suhn Kyong Rhie; Christine B Ambrosone; Kristiina Aittomäki; Pilar Amiano; Carmel Apicella; Laura Baglietto; Elisa V Bandera; Matthias W Beckmann; Christine D Berg; Leslie Bernstein; Carl Blomqvist; Hiltrud Brauch; Louise Brinton; Quang M Bui; Julie E Buring; Saundra S Buys; Daniele Campa; Jane E Carpenter; Daniel I Chasman; Jenny Chang-Claude; Constance Chen; Françoise Clavel-Chapelon; Angela Cox; Simon S Cross; Kamila Czene; Sandra L Deming; Robert B Diasio; W Ryan Diver; Alison M Dunning; Lorraine Durcan; Arif B Ekici; Peter A Fasching; Heather Spencer Feigelson; Laura Fejerman; Jonine D Figueroa; Olivia Fletcher; Dieter Flesch-Janys; Mia M Gaudet; Susan M Gerty; Jorge L Rodriguez-Gil; Graham G Giles; Carla H van Gils; Andrew K Godwin; Nikki Graham; Dario Greco; Per Hall; Susan E Hankinson; Arndt Hartmann; Rebecca Hein; Judith Heinz; Robert N Hoover; John L Hopper; Jennifer J Hu; Scott Huntsman; Sue A Ingles; Astrid Irwanto; Claudine Isaacs; Kevin B Jacobs; Esther M John; Christina Justenhoven; Rudolf Kaaks; Laurence N Kolonel; Gerhard A Coetzee; Mark Lathrop; Loic Le Marchand; Adam M Lee; I-Min Lee; Timothy Lesnick; Peter Lichtner; Jianjun Liu; Eiliv Lund; Enes Makalic; Nicholas G Martin; Catriona A McLean; Hanne Meijers-Heijboer; Alfons Meindl; Penelope Miron; Kristine R Monroe; Grant W Montgomery; Bertram Müller-Myhsok; Stefan Nickels; Sarah J Nyante; Curtis Olswold; Kim Overvad; Domenico Palli; Daniel J Park; Julie R Palmer; Harsh Pathak; Julian Peto; Paul Pharoah; Nazneen Rahman; Fernando Rivadeneira; Daniel F Schmidt; Rita K Schmutzler; Susan Slager; Melissa C Southey; Kristen N Stevens; Hans-Peter Sinn; Michael F Press; Eric Ross; Elio Riboli; Paul M Ridker; Fredrick R Schumacher; Gianluca Severi; Isabel Dos Santos Silva; Jennifer Stone; Malin Sund; William J Tapper; Michael J Thun; Ruth C Travis; Clare Turnbull; Andre G Uitterlinden; Quinten Waisfisz; Xianshu Wang; Zhaoming Wang; Joellen Weaver; Rüdiger Schulz-Wendtland; Lynne R Wilkens; David Van Den Berg; Wei Zheng; Regina G Ziegler; Elad Ziv; Heli Nevanlinna; Douglas F Easton; David J Hunter; Brian E Henderson; Stephen J Chanock; Montserrat Garcia-Closas; Peter Kraft; Christopher A Haiman; Celine M Vachon
Journal:  Hum Mol Genet       Date:  2012-09-13       Impact factor: 6.150

5.  Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk.

Authors:  Xingyi Guo; Jirong Long; Chenjie Zeng; Kyriaki Michailidou; Maya Ghoussaini; Manjeet K Bolla; Qin Wang; Roger L Milne; Xiao-Ou Shu; Qiuyin Cai; Jonathan Beesley; Siddhartha P Kar; Irene L Andrulis; Hoda Anton-Culver; Volker Arndt; Matthias W Beckmann; Alicia Beeghly-Fadiel; Javier Benitez; William Blot; Natalia Bogdanova; Stig E Bojesen; Hiltrud Brauch; Hermann Brenner; Louise Brinton; Annegien Broeks; Thomas Brüning; Barbara Burwinkel; Hui Cai; Sander Canisius; Jenny Chang-Claude; Ji-Yeob Choi; Fergus J Couch; Angela Cox; Simon S Cross; Kamila Czene; Hatef Darabi; Peter Devilee; Arnaud Droit; Thilo Dörk; Peter A Fasching; Olivia Fletcher; Henrik Flyger; Florentia Fostira; Valerie Gaborieau; Montserrat García-Closas; Graham G Giles; Mervi Grip; Pascal Guénel; Christopher A Haiman; Ute Hamann; Mikael Hartman; Antoinette Hollestelle; John L Hopper; Chia-Ni Hsiung; Hidemi Ito; Anna Jakubowska; Nichola Johnson; Maria Kabisch; Daehee Kang; Sofia Khan; Julia A Knight; Veli-Matti Kosma; Diether Lambrechts; Loic Le Marchand; Jingmei Li; Annika Lindblom; Artitaya Lophatananon; Jan Lubinski; Arto Mannermaa; Siranoush Manoukian; Sara Margolin; Frederik Marme; Keitaro Matsuo; Catriona A McLean; Alfons Meindl; Kenneth Muir; Susan L Neuhausen; Heli Nevanlinna; Silje Nord; Janet E Olson; Nick Orr; Paolo Peterlongo; Thomas Choudary Putti; Anja Rudolph; Suleeporn Sangrajrang; Elinor J Sawyer; Marjanka K Schmidt; Rita K Schmutzler; Chen-Yang Shen; Jiajun Shi; Martha J Shrubsole; Melissa C Southey; Anthony Swerdlow; Soo Hwang Teo; Bernard Thienpont; Amanda Ewart Toland; Robert A E M Tollenaar; Ian P M Tomlinson; Thérèse Truong; Chiu-Chen Tseng; Ans van den Ouweland; Wanqing Wen; Robert Winqvist; Anna Wu; Cheng Har Yip; M Pilar Zamora; Ying Zheng; Per Hall; Paul D P Pharoah; Jacques Simard; Georgia Chenevix-Trench; Alison M Dunning; Douglas F Easton; Wei Zheng
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2015-09-09       Impact factor: 4.254

6.  Genome-wide association study identifies novel breast cancer susceptibility loci.

Authors:  Douglas F Easton; Karen A Pooley; Alison M Dunning; Paul D P Pharoah; Deborah Thompson; Dennis G Ballinger; Jeffery P Struewing; Jonathan Morrison; Helen Field; Robert Luben; Nicholas Wareham; Shahana Ahmed; Catherine S Healey; Richard Bowman; Kerstin B Meyer; Christopher A Haiman; Laurence K Kolonel; Brian E Henderson; Loic Le Marchand; Paul Brennan; Suleeporn Sangrajrang; Valerie Gaborieau; Fabrice Odefrey; Chen-Yang Shen; Pei-Ei Wu; Hui-Chun Wang; Diana Eccles; D Gareth Evans; Julian Peto; Olivia Fletcher; Nichola Johnson; Sheila Seal; Michael R Stratton; Nazneen Rahman; Georgia Chenevix-Trench; Stig E Bojesen; Børge G Nordestgaard; Christen K Axelsson; Montserrat Garcia-Closas; Louise Brinton; Stephen Chanock; Jolanta Lissowska; Beata Peplonska; Heli Nevanlinna; Rainer Fagerholm; Hannaleena Eerola; Daehee Kang; Keun-Young Yoo; Dong-Young Noh; Sei-Hyun Ahn; David J Hunter; Susan E Hankinson; David G Cox; Per Hall; Sara Wedren; Jianjun Liu; Yen-Ling Low; Natalia Bogdanova; Peter Schürmann; Thilo Dörk; Rob A E M Tollenaar; Catharina E Jacobi; Peter Devilee; Jan G M Klijn; Alice J Sigurdson; Michele M Doody; Bruce H Alexander; Jinghui Zhang; Angela Cox; Ian W Brock; Gordon MacPherson; Malcolm W R Reed; Fergus J Couch; Ellen L Goode; Janet E Olson; Hanne Meijers-Heijboer; Ans van den Ouweland; André Uitterlinden; Fernando Rivadeneira; Roger L Milne; Gloria Ribas; Anna Gonzalez-Neira; Javier Benitez; John L Hopper; Margaret McCredie; Melissa Southey; Graham G Giles; Chris Schroen; Christina Justenhoven; Hiltrud Brauch; Ute Hamann; Yon-Dschun Ko; Amanda B Spurdle; Jonathan Beesley; Xiaoqing Chen; Arto Mannermaa; Veli-Matti Kosma; Vesa Kataja; Jaana Hartikainen; Nicholas E Day; David R Cox; Bruce A J Ponder
Journal:  Nature       Date:  2007-06-28       Impact factor: 49.962

7.  Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.

Authors:  Wei-Yu Lin; Nicola J Camp; Maya Ghoussaini; Jonathan Beesley; Kyriaki Michailidou; John L Hopper; Carmel Apicella; Melissa C Southey; Jennifer Stone; Marjanka K Schmidt; Annegien Broeks; Laura J Van't Veer; Emiel J Th Rutgers; Kenneth Muir; Artitaya Lophatananon; Sarah Stewart-Brown; Pornthep Siriwanarangsan; Peter A Fasching; Lothar Haeberle; Arif B Ekici; Matthias W Beckmann; Julian Peto; Isabel Dos-Santos-Silva; Olivia Fletcher; Nichola Johnson; Manjeet K Bolla; Qin Wang; Joe Dennis; Elinor J Sawyer; Timothy Cheng; Ian Tomlinson; Michael J Kerin; Nicola Miller; Frederik Marmé; Harald M Surowy; Barbara Burwinkel; Pascal Guénel; Thérèse Truong; Florence Menegaux; Claire Mulot; Stig E Bojesen; Børge G Nordestgaard; Sune F Nielsen; Henrik Flyger; Javier Benitez; M Pilar Zamora; Jose Ignacio Arias Perez; Primitiva Menéndez; Anna González-Neira; Guillermo Pita; M Rosario Alonso; Nuria Alvarez; Daniel Herrero; Hoda Anton-Culver; Hermann Brenner; Aida Karina Dieffenbach; Volker Arndt; Christa Stegmaier; Alfons Meindl; Peter Lichtner; Rita K Schmutzler; Bertram Müller-Myhsok; Hiltrud Brauch; Thomas Brüning; Yon-Dschun Ko; Daniel C Tessier; Daniel Vincent; Francois Bacot; Heli Nevanlinna; Kristiina Aittomäki; Carl Blomqvist; Sofia Khan; Keitaro Matsuo; Hidemi Ito; Hiroji Iwata; Akiyo Horio; Natalia V Bogdanova; Natalia N Antonenkova; Thilo Dörk; Annika Lindblom; Sara Margolin; Arto Mannermaa; Vesa Kataja; Veli-Matti Kosma; Jaana M Hartikainen; Anna H Wu; Chiu-Chen Tseng; David Van Den Berg; Daniel O Stram; Patrick Neven; Els Wauters; Hans Wildiers; Diether Lambrechts; Jenny Chang-Claude; Anja Rudolph; Petra Seibold; Dieter Flesch-Janys; Paolo Radice; Paolo Peterlongo; Siranoush Manoukian; Bernardo Bonanni; Fergus J Couch; Xianshu Wang; Celine Vachon; Kristen Purrington; Graham G Giles; Roger L Milne; Catriona Mclean; Christopher A Haiman; Brian E Henderson; Fredrick Schumacher; Loic Le Marchand; Jacques Simard; Mark S Goldberg; France Labrèche; Martine Dumont; Soo Hwang Teo; Cheng Har Yip; Norhashimah Hassan; Eranga Nishanthie Vithana; Vessela Kristensen; Wei Zheng; Sandra Deming-Halverson; Martha J Shrubsole; Jirong Long; Robert Winqvist; Katri Pylkäs; Arja Jukkola-Vuorinen; Saila Kauppila; Irene L Andrulis; Julia A Knight; Gord Glendon; Sandrine Tchatchou; Peter Devilee; Robert A E M Tollenaar; Caroline Seynaeve; Christi J Van Asperen; Montserrat García-Closas; Jonine Figueroa; Jolanta Lissowska; Louise Brinton; Kamila Czene; Hatef Darabi; Mikael Eriksson; Judith S Brand; Maartje J Hooning; Antoinette Hollestelle; Ans M W Van Den Ouweland; Agnes Jager; Jingmei Li; Jianjun Liu; Keith Humphreys; Xiao-Ou Shu; Wei Lu; Yu-Tang Gao; Hui Cai; Simon S Cross; Malcolm W R Reed; William Blot; Lisa B Signorello; Qiuyin Cai; Paul D P Pharoah; Barbara Perkins; Mitul Shah; Fiona M Blows; Daehee Kang; Keun-Young Yoo; Dong-Young Noh; Mikael Hartman; Hui Miao; Kee Seng Chia; Thomas Choudary Putti; Ute Hamann; Craig Luccarini; Caroline Baynes; Shahana Ahmed; Mel Maranian; Catherine S Healey; Anna Jakubowska; Jan Lubinski; Katarzyna Jaworska-Bieniek; Katarzyna Durda; Suleeporn Sangrajrang; Valerie Gaborieau; Paul Brennan; James Mckay; Susan Slager; Amanda E Toland; Drakoulis Yannoukakos; Chen-Yang Shen; Chia-Ni Hsiung; Pei-Ei Wu; Shian-Ling Ding; Alan Ashworth; Michael Jones; Nick Orr; Anthony J Swerdlow; Helen Tsimiklis; Enes Makalic; Daniel F Schmidt; Quang M Bui; Stephen J Chanock; David J Hunter; Rebecca Hein; Norbert Dahmen; Lars Beckmann; Kirsimari Aaltonen; Taru A Muranen; Tuomas Heikkinen; Astrid Irwanto; Nazneen Rahman; Clare A Turnbull; Quinten Waisfisz; Hanne E J Meijers-Heijboer; Muriel A Adank; Rob B Van Der Luijt; Per Hall; Georgia Chenevix-Trench; Alison Dunning; Douglas F Easton; Angela Cox
Journal:  Hum Mol Genet       Date:  2014-08-28       Impact factor: 6.150

8.  Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.

Authors:  Qiuyin Cai; Ben Zhang; Hyuna Sung; Siew-Kee Low; Sun-Seog Kweon; Wei Lu; Jiajun Shi; Jirong Long; Wanqing Wen; Ji-Yeob Choi; Dong-Young Noh; Chen-Yang Shen; Keitaro Matsuo; Soo-Hwang Teo; Mi Kyung Kim; Ui Soon Khoo; Motoki Iwasaki; Mikael Hartman; Atsushi Takahashi; Kyota Ashikawa; Koichi Matsuda; Min-Ho Shin; Min Ho Park; Ying Zheng; Yong-Bing Xiang; Bu-Tian Ji; Sue K Park; Pei-Ei Wu; Chia-Ni Hsiung; Hidemi Ito; Yoshio Kasuga; Peter Kang; Shivaani Mariapun; Sei Hyun Ahn; Han Sung Kang; Kelvin Y K Chan; Ellen P S Man; Hiroji Iwata; Shoichiro Tsugane; Hui Miao; Jiemin Liao; Yusuke Nakamura; Michiaki Kubo; Ryan J Delahanty; Yanfeng Zhang; Bingshan Li; Chun Li; Yu-Tang Gao; Xiao-Ou Shu; Daehee Kang; Wei Zheng
Journal:  Nat Genet       Date:  2014-07-20       Impact factor: 38.330

9.  Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.

Authors:  Chenjie Zeng; Xingyi Guo; Jirong Long; Karoline B Kuchenbaecker; Arnaud Droit; Kyriaki Michailidou; Maya Ghoussaini; Siddhartha Kar; Adam Freeman; John L Hopper; Roger L Milne; Manjeet K Bolla; Qin Wang; Joe Dennis; Simona Agata; Shahana Ahmed; Kristiina Aittomäki; Irene L Andrulis; Hoda Anton-Culver; Natalia N Antonenkova; Adalgeir Arason; Volker Arndt; Banu K Arun; Brita Arver; Francois Bacot; Daniel Barrowdale; Caroline Baynes; Alicia Beeghly-Fadiel; Javier Benitez; Marina Bermisheva; Carl Blomqvist; William J Blot; Natalia V Bogdanova; Stig E Bojesen; Bernardo Bonanni; Anne-Lise Borresen-Dale; Judith S Brand; Hiltrud Brauch; Paul Brennan; Hermann Brenner; Annegien Broeks; Thomas Brüning; Barbara Burwinkel; Saundra S Buys; Qiuyin Cai; Trinidad Caldes; Ian Campbell; Jane Carpenter; Jenny Chang-Claude; Ji-Yeob Choi; Kathleen B M Claes; Christine Clarke; Angela Cox; Simon S Cross; Kamila Czene; Mary B Daly; Miguel de la Hoya; Kim De Leeneer; Peter Devilee; Orland Diez; Susan M Domchek; Michele Doody; Cecilia M Dorfling; Thilo Dörk; Isabel Dos-Santos-Silva; Martine Dumont; Miriam Dwek; Bernd Dworniczak; Kathleen Egan; Ursula Eilber; Zakaria Einbeigi; Bent Ejlertsen; Steve Ellis; Debra Frost; Fiona Lalloo; Peter A Fasching; Jonine Figueroa; Henrik Flyger; Michael Friedlander; Eitan Friedman; Gaetana Gambino; Yu-Tang Gao; Judy Garber; Montserrat García-Closas; Andrea Gehrig; Francesca Damiola; Fabienne Lesueur; Sylvie Mazoyer; Dominique Stoppa-Lyonnet; Graham G Giles; Andrew K Godwin; David E Goldgar; Anna González-Neira; Mark H Greene; Pascal Guénel; Lothar Haeberle; Christopher A Haiman; Emily Hallberg; Ute Hamann; Thomas V O Hansen; Steven Hart; Jaana M Hartikainen; Mikael Hartman; Norhashimah Hassan; Sue Healey; Frans B L Hogervorst; Senno Verhoef; Carolyn B Hendricks; Peter Hillemanns; Antoinette Hollestelle; Peter J Hulick; David J Hunter; Evgeny N Imyanitov; Claudine Isaacs; Hidemi Ito; Anna Jakubowska; Ramunas Janavicius; Katarzyna Jaworska-Bieniek; Uffe Birk Jensen; Esther M John; Charles Joly Beauparlant; Michael Jones; Maria Kabisch; Daehee Kang; Beth Y Karlan; Saila Kauppila; Michael J Kerin; Sofia Khan; Elza Khusnutdinova; Julia A Knight; Irene Konstantopoulou; Peter Kraft; Ava Kwong; Yael Laitman; Diether Lambrechts; Conxi Lazaro; Loic Le Marchand; Chuen Neng Lee; Min Hyuk Lee; Jenny Lester; Jingmei Li; Annelie Liljegren; Annika Lindblom; Artitaya Lophatananon; Jan Lubinski; Phuong L Mai; Arto Mannermaa; Siranoush Manoukian; Sara Margolin; Frederik Marme; Keitaro Matsuo; Lesley McGuffog; Alfons Meindl; Florence Menegaux; Marco Montagna; Kenneth Muir; Anna Marie Mulligan; Katherine L Nathanson; Susan L Neuhausen; Heli Nevanlinna; Polly A Newcomb; Silje Nord; Robert L Nussbaum; Kenneth Offit; Edith Olah; Olufunmilayo I Olopade; Curtis Olswold; Ana Osorio; Laura Papi; Tjoung-Won Park-Simon; Ylva Paulsson-Karlsson; Stephanie Peeters; Bernard Peissel; Paolo Peterlongo; Julian Peto; Georg Pfeiler; Catherine M Phelan; Nadege Presneau; Paolo Radice; Nazneen Rahman; Susan J Ramus; Muhammad Usman Rashid; Gad Rennert; Kerstin Rhiem; Anja Rudolph; Ritu Salani; Suleeporn Sangrajrang; Elinor J Sawyer; Marjanka K Schmidt; Rita K Schmutzler; Minouk J Schoemaker; Peter Schürmann; Caroline Seynaeve; Chen-Yang Shen; Martha J Shrubsole; Xiao-Ou Shu; Alice Sigurdson; Christian F Singer; Susan Slager; Penny Soucy; Melissa Southey; Doris Steinemann; Anthony Swerdlow; Csilla I Szabo; Sandrine Tchatchou; Manuel R Teixeira; Soo H Teo; Mary Beth Terry; Daniel C Tessier; Alex Teulé; Mads Thomassen; Laima Tihomirova; Marc Tischkowitz; Amanda E Toland; Nadine Tung; Clare Turnbull; Ans M W van den Ouweland; Elizabeth J van Rensburg; David Ven den Berg; Joseph Vijai; Shan Wang-Gohrke; Jeffrey N Weitzel; Alice S Whittemore; Robert Winqvist; Tien Y Wong; Anna H Wu; Drakoulis Yannoukakos; Jyh-Cherng Yu; Paul D P Pharoah; Per Hall; Georgia Chenevix-Trench; Alison M Dunning; Jacques Simard; Fergus J Couch; Antonis C Antoniou; Douglas F Easton; Wei Zheng
Journal:  Breast Cancer Res       Date:  2016-06-21       Impact factor: 6.466

10.  Regulators of genetic risk of breast cancer identified by integrative network analysis.

Authors:  Mauro A A Castro; Ines de Santiago; Thomas M Campbell; Courtney Vaughn; Theresa E Hickey; Edith Ross; Wayne D Tilley; Florian Markowetz; Bruce A J Ponder; Kerstin B Meyer
Journal:  Nat Genet       Date:  2015-11-30       Impact factor: 38.330
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  31 in total

1.  Identifying Putative Susceptibility Genes and Evaluating Their Associations with Somatic Mutations in Human Cancers.

Authors:  Zhishan Chen; Wanqing Wen; Alicia Beeghly-Fadiel; Xiao-Ou Shu; Virginia Díez-Obrero; Jirong Long; Jiandong Bao; Jing Wang; Qi Liu; Qiuyin Cai; Victor Moreno; Wei Zheng; Xingyi Guo
Journal:  Am J Hum Genet       Date:  2019-08-08       Impact factor: 11.025

2.  eQTL Colocalization Analyses Identify NTN4 as a Candidate Breast Cancer Risk Gene.

Authors:  Jonathan Beesley; Haran Sivakumaran; Mahdi Moradi Marjaneh; Wei Shi; Kristine M Hillman; Susanne Kaufmann; Nehal Hussein; Siddhartha Kar; Luize G Lima; Sunyoung Ham; Andreas Möller; Georgia Chenevix-Trench; Stacey L Edwards; Juliet D French
Journal:  Am J Hum Genet       Date:  2020-08-31       Impact factor: 11.025

Review 3.  Unravelling the complex genetics of common kidney diseases: from variants to mechanisms.

Authors:  Katie Marie Sullivan; Katalin Susztak
Journal:  Nat Rev Nephrol       Date:  2020-06-08       Impact factor: 28.314

4.  Epigenome-wide scan identifies differentially methylated regions for lung cancer using pre-diagnostic peripheral blood.

Authors:  Naisi Zhao; Mengyuan Ruan; Devin C Koestler; Jiayun Lu; Carmen J Marsit; Karl T Kelsey; Elizabeth A Platz; Dominique S Michaud
Journal:  Epigenetics       Date:  2021-05-19       Impact factor: 4.528

5.  Multi-omics analysis to identify susceptibility genes for colorectal cancer.

Authors:  Yuan Yuan; Jiandong Bao; Zhishan Chen; Anna Díez Villanueva; Wanqing Wen; Fangqin Wang; Dejian Zhao; Xianghui Fu; Qiuyin Cai; Jirong Long; Xiao-Ou Shu; Deyou Zheng; Victor Moreno; Wei Zheng; Weiqiang Lin; Xingyi Guo
Journal:  Hum Mol Genet       Date:  2021-04-27       Impact factor: 6.150

6.  Functional Genomic Analyses of the 21q22.3 Locus Identifying Functional Variants and Candidate Gene YBEY for Breast Cancer Risk.

Authors:  Chris Shidal; Xiang Shu; Jie Wu; Jifeng Wang; Shuya Huang; Jirong Long; Joshua A Bauer; Jie Ping; Xingyi Guo; Wei Zheng; Xiao-Ou Shu; Qiuyin Cai
Journal:  Cancers (Basel)       Date:  2021-04-23       Impact factor: 6.639

7.  The Association Between STX1B Polymorphisms and Treatment Response in Patients With Epilepsy.

Authors:  Shitao Wang; Liang Zhou; Chenglu He; Dan Wang; Xuemei Cai; Yanying Yu; Liling Chen; Di Lu; Ligong Bian; Sunbing Du; Qian Wu; Yanbing Han
Journal:  Front Pharmacol       Date:  2021-07-09       Impact factor: 5.810

8.  CRISPRi-mediated functional analysis of lung disease-associated loci at non-coding regions.

Authors:  William D Stuart; Minzhe Guo; Iris M Fink-Baldauf; Alan M Coleman; John P Clancy; Marcus A Mall; Foong-Yen Lim; John J Brewington; Yutaka Maeda
Journal:  NAR Genom Bioinform       Date:  2020-05-25

9.  Discovery of rare coding variants in OGDHL and BRCA2 in relation to breast cancer risk in Chinese women.

Authors:  Xingyi Guo; Jirong Long; Zhishan Chen; Xiao-Ou Shu; Yong-Bing Xiang; Wanqing Wen; Chenjie Zeng; Yu-Tang Gao; Qiuyin Cai; Wei Zheng
Journal:  Int J Cancer       Date:  2019-12-27       Impact factor: 7.396

10.  Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects.

Authors:  Xingyi Guo; Weiqiang Lin; Wanqing Wen; Jeroen Huyghe; Stephanie Bien; Qiuyin Cai; Tabitha Harrison; Zhishan Chen; Conghui Qu; Jiandong Bao; Jirong Long; Yuan Yuan; Fangqin Wang; Mengqiu Bai; Goncalo R Abecasis; Demetrius Albanes; Sonja I Berndt; Stéphane Bézieau; D Timothy Bishop; Hermann Brenner; Stephan Buch; Andrea Burnett-Hartman; Peter T Campbell; Sergi Castellví-Bel; Andrew T Chan; Jenny Chang-Claude; Stephen J Chanock; Sang Hee Cho; David V Conti; Albert de la Chapelle; Edith J M Feskens; Steven J Gallinger; Graham G Giles; Phyllis J Goodman; Andrea Gsur; Mark Guinter; Marc J Gunter; Jochen Hampe; Heather Hampel; Richard B Hayes; Michael Hoffmeister; Ellen Kampman; Hyun Min Kang; Temitope O Keku; Hyeong Rok Kim; Loic Le Marchand; Soo Chin Lee; Christopher I Li; Li Li; Annika Lindblom; Noralane Lindor; Roger L Milne; Victor Moreno; Neil Murphy; Polly A Newcomb; Deborah A Nickerson; Kenneth Offit; Rachel Pearlman; Paul D P Pharoah; Elizabeth A Platz; John D Potter; Gad Rennert; Lori C Sakoda; Clemens Schafmayer; Stephanie L Schmit; Robert E Schoen; Fredrick R Schumacher; Martha L Slattery; Yu-Ru Su; Catherine M Tangen; Cornelia M Ulrich; Franzel J B van Duijnhoven; Bethany Van Guelpen; Kala Visvanathan; Pavel Vodicka; Ludmila Vodickova; Veronika Vymetalkova; Xiaoliang Wang; Emily White; Alicja Wolk; Michael O Woods; Graham Casey; Li Hsu; Mark A Jenkins; Stephen B Gruber; Ulrike Peters; Wei Zheng
Journal:  Gastroenterology       Date:  2020-10-12       Impact factor: 33.883
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