José Luis Ayala-Herrera1,2, Carlos Abud-Mendoza3, Roberto F Gonzalez-Amaro1, Leon Francisco Espinosa-Cristobal4, Rita Elizabeth Martínez-Martínez1,2. 1. a Doctorado en Ciencias Biomedicas Basicas, Facultad de Medicina , Universidad Autonoma de San Luis Potosi , San Luis Potosi , Mexico. 2. b Dental Science with Specialization in Advanced General Dentistry Program , San Luis Potosi University , San Luis Potosi , Mexico. 3. c Regional Unit of Rheumatology and Osteoporosis at Central Hospital "Dr. Ignacio Morones Prieto", Faculty of Medicine, San Luis Potosi University , San Luis Potosi , Mexico. 4. d Departamento de Estomatología del Instituto de Ciencias Biomédicas, Universidad Autonoma de Ciudad Juarez , Chihuahua , Mexico.
Abstract
OBJECTIVE: To determine and compare the distribution of Porphyromonas gingivalis fimA genotypes in patients affected by Rheumatoid arthritis (RA) and periodontitis (PE). MATERIALS AND METHODS: This study involved 394 subjects divided into four groups, RA, PE, RA and PE and healthy subjects. PE was diagnosed by using clinical attachment loss (CAL) and probing depth (PD) indexes. Presence of P. gingivalis and its genotypes was identified by polymerase chain reaction in subgingival biofilm. RESULTS: P. gingivalis was more frequent in patients with RA (82.69%), and fimA II genotype was the most frequent in all groups, especially in PE/RA (76.71%). There was statistical difference (p < .05) regarding the frequency of P. gingivalis genotypes such as fimA Ib, II and III. CONCLUSIONS: Distribution of P. gingivalis fimA II genotypes was different among groups, it could play a critical role in the presence of PE in RA patients.
OBJECTIVE: To determine and compare the distribution of Porphyromonas gingivalis fimA genotypes in patients affected by Rheumatoid arthritis (RA) and periodontitis (PE). MATERIALS AND METHODS: This study involved 394 subjects divided into four groups, RA, PE, RA and PE and healthy subjects. PE was diagnosed by using clinical attachment loss (CAL) and probing depth (PD) indexes. Presence of P. gingivalis and its genotypes was identified by polymerase chain reaction in subgingival biofilm. RESULTS:P. gingivalis was more frequent in patients with RA (82.69%), and fimA II genotype was the most frequent in all groups, especially in PE/RA (76.71%). There was statistical difference (p < .05) regarding the frequency of P. gingivalis genotypes such as fimA Ib, II and III. CONCLUSIONS: Distribution of P. gingivalis fimA II genotypes was different among groups, it could play a critical role in the presence of PE in RApatients.
Entities:
Keywords:
P. gingivalis; fimA genotypes; periodontitis; rheumatoid arthritis