Literature DB >> 29725735

Treatment of infection following intramedullary nailing of tibial shaft fractures-results of the ORS/ISFR expert group survey.

Cyril Mauffrey1, David J Hak2, Peter Giannoudis2, Volker Alt2, Christoph Nau2, Ingo Marzi2, Peter Augat2, J K Oh2, Johannes Frank2, Andreas Mavrogenis2, Xavier Flecher2, Jean-Noel Argenson2, Ashok Gavaskar2, David Rojas2, Yehia H Bedeir2.   

Abstract

OBJECTIVE: The lack of universally accepted treatment principles and protocols to manage infected intramedullary (IM) nails following tibial fractures continues to challenge us, eliciting a demand for clear guidelines. Our response to this problem was to create an ORS/ISFR taskforce to identify potential solutions and trends based on published evidence and practices globally.
MATERIALS AND METHODS: A questionnaire of reported treatment methods was created based on a published meta-analysis on the topic. Treatment methods were divided in two groups: A (retained nail) and B (nail removed). Experts scored the questionnaire items on a scale of 1-4 twice, before and after revealing the success rates for each stage of infection. Inter- and intra-observer variability analysis among experts' personal scores and between experts' scores was performed. An agreement mean and correlation degree between experts' scores was calculated. Finally, a success rate report between groups was performed.
RESULTS: Experts underestimated success rate of an individual treatment method compared to published data. The mean difference between experts' scores and published results was + 26.3 ± 46 percentage points. Inter-observer agreement mean was poor (< 0.2) for both rounds. Intra-observer agreement mean across different treatment methods showed a wide variability (18.3 to 64.8%). Experts agree more with published results for nail removal on stage 2 and 3 infections.
CONCLUSIONS: Experts' and published data strongly agree to retain the implant for stage 1 infections. A more aggressive approach (nail removal) favoured for infection stages 2 and 3. However, literature supports both treatment strategies. EVIDENCE: Clinical Question.

Entities:  

Keywords:  Intramedullary nailing; Nonunion tibia; Survey on nonunion; Tibia fractures; Tibia infection; Treatment algorithm

Mesh:

Year:  2018        PMID: 29725735     DOI: 10.1007/s00264-018-3964-1

Source DB:  PubMed          Journal:  Int Orthop        ISSN: 0341-2695            Impact factor:   3.075


  23 in total

Review 1.  Reamed intramedullary tibial nailing: an overview and analysis of 1106 cases.

Authors:  C M Court-Brown
Journal:  J Orthop Trauma       Date:  2004-02       Impact factor: 2.512

2.  Infection after intramedullary nailing of the tibia. Incidence and protocol for management.

Authors:  C M Court-Brown; J F Keating; M M McQueen
Journal:  J Bone Joint Surg Br       Date:  1992-09

3.  Current bacterial speciation and antibiotic resistance in deep infections after operative fixation of fractures.

Authors:  Jesse T Torbert; Manjari Joshi; Adrienne Moraff; Paul E Matuszewski; Amanda Holmes; Andrew N Pollak; Robert V OʼToole
Journal:  J Orthop Trauma       Date:  2015-01       Impact factor: 2.512

Review 4.  Classification of non-union: need for a new scoring system?

Authors:  Giorgio Maria Calori; Mark Phillips; Sharanpal Jeetle; Lorenzo Tagliabue; P V Giannoudis
Journal:  Injury       Date:  2008-09       Impact factor: 2.586

5.  Management of infected nonunion of the long bones by a multidisciplinary team.

Authors:  D Bose; R Kugan; D Stubbs; M McNally
Journal:  Bone Joint J       Date:  2015-06       Impact factor: 5.082

6.  Modified classification and single-stage microsurgical repair of posttraumatic infected massive bone defects in lower extremities.

Authors:  Yun-fa Yang; Zhong-he Xu; Guang-ming Zhang; Jian-wei Wang; Si-wang Hu; Zhi-qi Hou; Da-chuan Xu
Journal:  J Reconstr Microsurg       Date:  2013-06-26       Impact factor: 2.873

Review 7.  Does timing to operative debridement affect infectious complications in open long-bone fractures? A systematic review.

Authors:  Mara L Schenker; Sarah Yannascoli; Keith D Baldwin; Jaimo Ahn; Samir Mehta
Journal:  J Bone Joint Surg Am       Date:  2012-06-20       Impact factor: 5.284

8.  The effect of smoking on bone healing: A systematic review.

Authors:  R A Patel; R F Wilson; P A Patel; R M Palmer
Journal:  Bone Joint Res       Date:  2013-06-14       Impact factor: 5.853

9.  Bone and joint infections in adults: a comprehensive classification proposal.

Authors:  Carlo Luca Romanò; Delia Romanò; Nicola Logoluso; Lorenzo Drago
Journal:  Eur Orthop Traumatol       Date:  2011-04-14

10.  Management of infection after intramedullary nailing of long bone fractures: treatment protocols and outcomes.

Authors:  Kostas G Makridis; Theodoros Tosounidis; Peter V Giannoudis
Journal:  Open Orthop J       Date:  2013-06-14
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  3 in total

1.  Intramedullary application of local antibiotic bullets for the treatment of long bone fracture related infection.

Authors:  Preemal Patel; Alexis-Dimitris Iliadis; Alexandros Vris; Nima Heidari; Alex Trompeter
Journal:  Eur J Orthop Surg Traumatol       Date:  2022-01-13

2.  Microbiological diagnosis of intramedullary nailing infection: comparison of bacterial growth between tissue sampling and sonication fluid cultures.

Authors:  Carlos Augusto Finelli; Cely Barreto da Silva; Maria Aparecida Murça; Fernando Baldy Dos Reis; Natalia Miki; Helio Alvachian Fernandes; Adriana Dell'Aquila; Mauro José Salles
Journal:  Int Orthop       Date:  2020-08-11       Impact factor: 3.075

3.  Intramedullary reaming and irrigation and antibiotic-loaded calcium sulfate implantation for the treatment of infection after intramedullary nailing: a retrospective study of 19 cases.

Authors:  Hong-An Zhang; Chun-Hao Zhou; Xiang-Qing Meng; Jia Fang; Cheng-He Qin
Journal:  BMC Musculoskelet Disord       Date:  2020-10-28       Impact factor: 2.362

  3 in total

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