Claudia Arab1, Luiz Carlos Marques Vanderlei2, Laércio da Silva Paiva3, Kyle Levi Fulghum4, Carlos Elias Fristachi5, Afonso Celso Pinto Nazario6, Simone Elias6, Luiz Henrique Gebrim7, Celso Ferreira Filho8, Yori Gidron9, Celso Ferreira10. 1. Departamento de Medicina, Disciplina de Cardiologia, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo, 715 Napoleão de Barros St, São Paulo, 04024002, SP, Brazil. ac.arabclaudia@gmail.com. 2. Departamento de Fisioterapia, Faculdade de Ciência e Tecnologia, Universidade do Estado de São Paulo, 305 Roberto Símonsen St, Presidente Prudente, SP, 19060-900, Brazil. 3. Faculdade de Medicina do ABC, Laboratório de Epidemiologia e Análise de Dados, 2000 Lauro Gomes Av, Santo André, SP, 09060-870, Brazil. 4. Department of Physiology and Institute of Molecular Cardiology, School of Medicine, University of Louisville, Baxter Biomedical Research Building II, 590 S Preston St, Louisville, KY, 40202, USA. 5. Instituto do Câncer Doutor Arnaldo Vieira de Carvalho, 66 Largo do Arouche, São Paulo, SP, 01219-011, Brazil. 6. Departamento de Ginecologia, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil. 7. Centro de Referência da Saúde da Mulher, Hospital Pérola Byington, 683 Brigadeiro Luís Antônio Ave, São Paulo, SP, 01317-000, Brazil. 8. Departamento de Medicina, Disciplina de Clínica Médica, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil. 9. Free University of Brussels (VUB), Boulevard de la Plaine 2, 1050, Ixelles, Belgium. 10. Departamento de Medicina, Disciplina de Cardiologia, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo, 715 Napoleão de Barros St, São Paulo, 04024002, SP, Brazil.
Abstract
AIM: To compare cardiac autonomic modulation in early- versus advanced-stage breast cancer patients before any type of cancer treatment and investigate associated factors. METHODS AND RESULTS: This cross-sectional study included women (30-69 years old) with primary diagnosis of breast cancer and women with benign breast tumors. We evaluated cardiac modulation by heart rate variability and assessed factors of anxiety, depression, physical activity, and other relevant medical variables. Patients were divided into three groups based on TNM staging of cancer severity: early-stage cancer (n = 42), advanced-stage cancer (n = 37), or benign breast tumors to serve as a control (n = 37). We analyzed heart rate variability in time and frequency domains. The advanced-stage cancer group had lower vagal modulation than early-stage and benign groups; also, the advance-stage group had lower overall heart rate variability when compared to benign conditions. Heart rate variability was influenced by age, menopausal status, and BMI. CONCLUSIONS: Heart rate variability seems to be a promising, non-invasive tool for early diagnosis of autonomic dysfunction in breast cancer and detection of cardiovascular impairments at cancer diagnosis. Cardiac autonomic modulation is inversely associated with breast cancer staging.
AIM: To compare cardiac autonomic modulation in early- versus advanced-stage breast cancerpatients before any type of cancer treatment and investigate associated factors. METHODS AND RESULTS: This cross-sectional study included women (30-69 years old) with primary diagnosis of breast cancer and women with benign breast tumors. We evaluated cardiac modulation by heart rate variability and assessed factors of anxiety, depression, physical activity, and other relevant medical variables. Patients were divided into three groups based on TNM staging of cancer severity: early-stage cancer (n = 42), advanced-stage cancer (n = 37), or benign breast tumors to serve as a control (n = 37). We analyzed heart rate variability in time and frequency domains. The advanced-stage cancer group had lower vagal modulation than early-stage and benign groups; also, the advance-stage group had lower overall heart rate variability when compared to benign conditions. Heart rate variability was influenced by age, menopausal status, and BMI. CONCLUSIONS: Heart rate variability seems to be a promising, non-invasive tool for early diagnosis of autonomic dysfunction in breast cancer and detection of cardiovascular impairments at cancer diagnosis. Cardiac autonomic modulation is inversely associated with breast cancer staging.
Entities:
Keywords:
Autonomic nervous system; Breast tumor; Cardiology; TNM classification
Authors: Andrew H Kemp; Andre R Brunoni; Itamar S Santos; Maria A Nunes; Eduardo M Dantas; Roberta Carvalho de Figueiredo; Alexandre C Pereira; Antonio L P Ribeiro; José G Mill; Rodrigo V Andreão; Julian F Thayer; Isabela M Benseñor; Paulo A Lotufo Journal: Am J Psychiatry Date: 2014-10-31 Impact factor: 18.112
Authors: R M Carney; J A Blumenthal; P K Stein; L Watkins; D Catellier; L F Berkman; S M Czajkowski; C O'Connor; P H Stone; K E Freedland Journal: Circulation Date: 2001-10-23 Impact factor: 29.690
Authors: Marcos Antonio Almeida-Santos; Jose Augusto Barreto-Filho; Joselina Luzia Menezes Oliveira; Francisco Prado Reis; Cristiane Costa da Cunha Oliveira; Antonio Carlos Sobral Sousa Journal: Arch Gerontol Geriatr Date: 2015-11-22 Impact factor: 3.250
Authors: Maxime Caru; Denis Corbin; Delphine Périé; Valérie Lemay; Jacques Delfrate; Simon Drouin; Laurence Bertout; Maja Krajinovic; Caroline Laverdière; Gregor Andelfinger; Daniel Sinnett; Daniel Curnier Journal: Clin Res Cardiol Date: 2019-02-18 Impact factor: 5.460