Claudia Arab1, Daniel Penteado Martins Dias2, Renata Thaís de Almeida Barbosa3, Tatiana Dias de Carvalho4, Vitor Engrácia Valenti5, Tânia Brusque Crocetta6, Marcelo Ferreira7, Luiz Carlos de Abreu8, Celso Ferreira9. 1. Departamento de Medicina (Cardiologia), Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), 715 Napoleão De Barros St., São Paulo, SP 04024-002, Brazil. Electronic address: ac.arabclaudia@gmail.com. 2. Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), 3900 Bandeirantes Av, Ribeirão Preto, SP 14049-900, Brazil. Electronic address: danielpenteado@gmail.com. 3. Departamento de Saúde da Coletividade, Faculdade de Medicina do ABC (FMABC), 821 P Rincipe De Gales Av, Santo Andre, SP 09060-650, Brazil. Electronic address: profrenatathais@gmail.com. 4. Departamento de Saúde da Coletividade, Faculdade de Medicina do ABC (FMABC), 821 P Rincipe De Gales Av, Santo Andre, SP 09060-650, Brazil. Electronic address: carvalho.td1@gmail.com. 5. Centro de Estudos do Sistema Nervoso Autônomo, Departamento de Fonoaudiologia, Faculdade de Filosofia e Ciências, Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP), 737 Hygino Muzzi Filho Av, Marília, SP 17525-901, Brazil. Electronic address: vitor.valenti@gmail.com. 6. Departamento de Saúde da Coletividade, Faculdade de Medicina do ABC (FMABC), 821 P Rincipe De Gales Av, Santo Andre, SP 09060-650, Brazil. Electronic address: taniabrusque@gmail.com. 7. Departamento de Saúde da Coletividade, Faculdade de Medicina do ABC (FMABC), 821 P Rincipe De Gales Av, Santo Andre, SP 09060-650, Brazil. Electronic address: doutormarcelof@gmail.com. 8. Departamento de Saúde da Coletividade, Faculdade de Medicina do ABC (FMABC), 821 P Rincipe De Gales Av, Santo Andre, SP 09060-650, Brazil; Faculdade de Saúde Pública, Universidade de São Paulo (USP), 715 Doutor Arnaldo Av, Sao Paulo, SP 01246-904, Brazil. Electronic address: abreu.luizcarlos@gmail.com. 9. Departamento de Medicina (Cardiologia), Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), 715 Napoleão De Barros St., São Paulo, SP 04024-002, Brazil. Electronic address: ferreira-celso@uol.com.br.
Abstract
PURPOSE: In the current study, we aimed to review literature findings showing the clinical importance of cardiac autonomic modulation assessed by heart rate variability analysis in breast cancer (BC) patients and survivors. METHODS: We conducted a systematic review according to The PRISMA Statement in Medline, Scopus and Web of Science (_-2015) databases. The search was limited to articles in English language, published in peer-reviewed journals, and with adult age samples only (e.g., women, patients, or survivors, diagnosed with BC in any stage). We included observational studies and randomized trials. Detailed heart rate variability analysis (instruments, data collection protocol, and analysis methods) was required. Search terms included autonomic nervous system, heart rate variability, sympathetic and parasympathetic nervous system, autonomic dysfunction, vagal nervous and breast neoplasms, breast cancer and breast tumor. RESULTS: Twelve studies were included in this review. The clinical importance of cardiac autonomic modulation assessed by heart rate variability analysis in BC patients and survivors is demonstrated by association with effects of BC surgery, and treatments, and the adverse effects of surgery and treatments on survivors (e.g., cardiotoxicity, fatigue, and stress). LIMITATIONS: The strength of evidence of included studies is low: small samples size and heterogeneity, presence of confounders, and observational studies design. CONCLUSIONS: The heart rate variability analysis could be used as a complementary non-invasive tool for the early diagnosis and better prognosis of autonomic dysfunction, and survival in BC patients. There are many potential clinical applications of heart rate variability analysis in BC patients, and the employment of such approaches could lead to lower impairment of autonomic function in this individuals.
PURPOSE: In the current study, we aimed to review literature findings showing the clinical importance of cardiac autonomic modulation assessed by heart rate variability analysis in breast cancer (BC) patients and survivors. METHODS: We conducted a systematic review according to The PRISMA Statement in Medline, Scopus and Web of Science (_-2015) databases. The search was limited to articles in English language, published in peer-reviewed journals, and with adult age samples only (e.g., women, patients, or survivors, diagnosed with BC in any stage). We included observational studies and randomized trials. Detailed heart rate variability analysis (instruments, data collection protocol, and analysis methods) was required. Search terms included autonomic nervous system, heart rate variability, sympathetic and parasympathetic nervous system, autonomic dysfunction, vagal nervous and breast neoplasms, breast cancer and breast tumor. RESULTS: Twelve studies were included in this review. The clinical importance of cardiac autonomic modulation assessed by heart rate variability analysis in BC patients and survivors is demonstrated by association with effects of BC surgery, and treatments, and the adverse effects of surgery and treatments on survivors (e.g., cardiotoxicity, fatigue, and stress). LIMITATIONS: The strength of evidence of included studies is low: small samples size and heterogeneity, presence of confounders, and observational studies design. CONCLUSIONS: The heart rate variability analysis could be used as a complementary non-invasive tool for the early diagnosis and better prognosis of autonomic dysfunction, and survival in BC patients. There are many potential clinical applications of heart rate variability analysis in BC patients, and the employment of such approaches could lead to lower impairment of autonomic function in this individuals.
Authors: K Boehm; M Duckheim; L Mizera; P Groga-Bada; N Malek; F Kreth; M Gawaz; C S Zuern; C Eick Journal: Support Care Cancer Date: 2018-04-12 Impact factor: 3.603
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Authors: Kord M Kober; Melissa Mazor; Gary Abrams; Adam Olshen; Yvette P Conley; Marilyn Hammer; Mark Schumacher; Margaret Chesney; Betty Smoot; Judy Mastick; Steven M Paul; Jon D Levine; Christine Miaskowski Journal: J Pain Symptom Manage Date: 2018-08-30 Impact factor: 3.612
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Authors: Talita Dias da Silva; Thais Massetti; Tânia Brusque Crocetta; Carlos Bandeira de Mello Monteiro; Alex Carll; Luiz Carlos Marques Vanderlei; Carlie Arbaugh; Fernando Rocha Oliveira; Luiz Carlos de Abreu; Celso Ferreira Filho; John Godleski; Celso Ferreira Journal: Pediatr Cardiol Date: 2018-04-25 Impact factor: 1.655
Authors: Daniel Escutia-Reyes; José Javier Reyes-Lagos; José de Jesús Garduño-García; Gerardo Emilio-López-Chávez; Ángel Gómez-Villanueva; Adriana Cristina Pliego-Carrillo; Alexandra Estela Soto-Piña Journal: Sci Rep Date: 2021-07-14 Impact factor: 4.379