Objective: Previous studies in children with ADHD identified two partially separable familial factors underlying cognitive dysfunction, but evidence in adolescents and adults is lacking. Here, we investigate the etiological structure of cognitive-neurophysiological impairments in ADHD in adolescents and young adults. Method: Factor analyses and multivariate familial models were run in 356 participants from ADHD and control sibling pairs aged 11 to 27 years on data on IQ, digit span forward (DSF) and backward (DSB), and cognitive-performance and event-related potential (ERP) measures from three cognitive tasks. Results: Three familial factors (cF1-3), showing substantial familial overlap with ADHD, captured the familial covariation of ADHD with nine cognitive-ERP measures. cF1 loaded on IQ, mean reaction time (MRT), and reaction-time variability (RTV); cF2 on DSF and DSB; and cF3 on number of errors and ERPs of inhibition and error processing. Conclusion: These results identify three partially separable etiological pathways leading to cognitive-neurophysiological impairments in adolescent and adult ADHD.
Objective: Previous studies in children with ADHD identified two partially separable familial factors underlying cognitive dysfunction, but evidence in adolescents and adults is lacking. Here, we investigate the etiological structure of cognitive-neurophysiological impairments in ADHD in adolescents and young adults. Method: Factor analyses and multivariate familial models were run in 356 participants from ADHD and control sibling pairs aged 11 to 27 years on data on IQ, digit span forward (DSF) and backward (DSB), and cognitive-performance and event-related potential (ERP) measures from three cognitive tasks. Results: Three familial factors (cF1-3), showing substantial familial overlap with ADHD, captured the familial covariation of ADHD with nine cognitive-ERP measures. cF1 loaded on IQ, mean reaction time (MRT), and reaction-time variability (RTV); cF2 on DSF and DSB; and cF3 on number of errors and ERPs of inhibition and error processing. Conclusion: These results identify three partially separable etiological pathways leading to cognitive-neurophysiological impairments in adolescent and adult ADHD.
Entities:
Keywords:
ADHD; adolescence; adulthood; cognitive performance; event-related potentials; family study
Authors: R G Karam; V Breda; F A Picon; D L Rovaris; M M Victor; C A I Salgado; E S Vitola; K L Silva; P O Guimarães-da-Silva; N R Mota; A Caye; P Belmonte-de-Abreu; L A Rohde; E H Grevet; C H D Bau Journal: Psychol Med Date: 2015-01-23 Impact factor: 7.723
Authors: Steven Boker; Michael Neale; Hermine Maes; Michael Wilde; Michael Spiegel; Timothy Brick; Jeffrey Spies; Ryne Estabrook; Sarah Kenny; Timothy Bates; Paras Mehta; John Fox Journal: Psychometrika Date: 2011-04-01 Impact factor: 2.500
Authors: J Kuntsi; A C Frazier-Wood; T Banaschewski; M Gill; A Miranda; R D Oades; H Roeyers; A Rothenberger; H-C Steinhausen; J J van der Meere; S V Faraone; P Asherson; F Rijsdijk Journal: Psychol Med Date: 2012-09-14 Impact factor: 7.723
Authors: Penny Andreou; Ben M Neale; Wai Chen; Hanna Christiansen; Isabel Gabriels; Alexander Heise; Sheera Meidad; Ueli C Muller; Henrik Uebel; Tobias Banaschewski; Iris Manor; Robert Oades; Herbert Roeyers; Aribert Rothenberger; Pak Sham; Hans-Christoph Steinhausen; Philip Asherson; Jonna Kuntsi Journal: Psychol Med Date: 2007-05-31 Impact factor: 7.723
Authors: Giorgia Michelini; Joseph Jurgiel; Ioannis Bakolis; Celeste H M Cheung; Philip Asherson; Sandra K Loo; Jonna Kuntsi; Iman Mohammad-Rezazadeh Journal: Transl Psychiatry Date: 2019-04-12 Impact factor: 6.222
Authors: Giorgia Michelini; Deanna M Barch; Yuan Tian; David Watson; Daniel N Klein; Roman Kotov Journal: Transl Psychiatry Date: 2019-10-17 Impact factor: 6.222
Authors: Agatha Lenartowicz; Holly Truong; Kristen D Enriquez; Julia Webster; Jean-Baptiste Pochon; Jesse Rissman; Carrie E Bearden; Sandra K Loo; Robert M Bilder Journal: Cogn Affect Behav Neurosci Date: 2021-06-21 Impact factor: 3.282